Results 41 to 50 of about 2,694 (155)

Pulp tissue from primary teeth: new source of stem cells

Journal of Applied Oral Science, 2011
SHED (stem cells from human exfoliated deciduous teeth) represent a population of postnatal stem cells capable of extensive proliferation and multipotential differentiation. Primary teeth may be an ideal source of postnatal stem cells to regenerate tooth
Paloma Dias Telles, Maria Aparecida de Andrade Moreira Machado, Vivien Thiemy Sakai, Jacques Eduardo Nör   +3 more
doaj   +1 more source

The use of human dental pulp stem cells for in vivo bone tissue engineering: A systematic review

Journal of Tissue Engineering, 2018
Dental pulp represents a promising and easily accessible source of mesenchymal stem cells for clinical applications. Many studies have investigated the use of human dental pulp stem cells and stem cells isolated from the dental pulp of human exfoliated ...
Alessander Leyendecker Junior, Carla Cristina Gomes Pinheiro, Tiago Lazzaretti Fernandes, Daniela Franco Bueno   +3 more
doaj   +1 more source

Stem Cells From Human Exfoliated Deciduous Teeth Alleviate Liver Cirrhosis via Inhibition of Gasdermin D-Executed Hepatocyte Pyroptosis

Frontiers in Immunology, 2022
Liver cirrhosis represents a type of end-stage liver disease with few effective therapies, which was characterized by damaged functional liver tissue due to long-term inflammation.
Peng Chen, Peng Chen, Peng Chen, Yi-kun Zhou, Yi-kun Zhou, Yi-kun Zhou, Chun-shan Han, Chun-shan Han, Chun-shan Han, Liu-jing Chen, Liu-jing Chen, Liu-jing Chen, Yi-ming Wang, Yi-ming Wang, Yi-ming Wang, Zi-meng Zhuang, Zi-meng Zhuang, Zi-meng Zhuang, Shuai Lin, Shuai Lin, Shuai Lin, Yan-heng Zhou, Yan-heng Zhou, Yan-heng Zhou, Jiu-hui Jiang, Jiu-hui Jiang, Jiu-hui Jiang, Rui-li Yang, Rui-li Yang, Rui-li Yang   +29 more
doaj   +1 more source

The effect of stem cell from human exfoliated deciduous teeth on T lymphocyte proliferation

Advanced Biomedical Research, 2014
Mesenchymal stem cells (MSC), a specific type of adult tissue stem cell; have the immunosuppressive effects that make them valuable targets for regenerative medicine and treatment of many human illnesses. Hence, MSC have been the subject of numerous studies. The classical source of MSC is adult bone marrow (BM).
Razieh Alipour, Minoo Adib, Batool Hashemi-Beni, Farzaneh Sadeghi   +3 more
openaire   +3 more sources

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Factors derived from human exfoliated deciduous teeth stem cells reverse neurological deficits in a zebrafish model of Parkinson's disease

Journal of Dental Sciences
Background/purpose: Mesenchymal stem cells exhibit therapeutic efficacy for brain injury. This study examined the effect of mesenchymal stem cells derived from human exfoliated deciduous teeth (SHED) on alleviating symptoms of Parkinson's disease (PD ...
Yong-Ren Chen, Chin-Chean Wong, Yi-No Chen, Bing-Heng Yang, Po-Hui Lee, Chia-Yang Shiau, Kuo-Chuan Wang, Chung-Hsing Li   +7 more
doaj   +1 more source

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

Role of the Stem Cells from Human Deciduous Teeth in Dentistry: A Review

Journal of Pharmacy and Bioallied Sciences
Stem cells isolated from human exfoliated deciduous teeth or SHED possess high rate of proliferation along with high osteogenic as well as neurogenic differentiation when compared with dental pulpal stem cells.
Madhura Pawar, Nilesh Rathi, Avinash Kharat, Ramesh Bhonde, Vinita C. Patole   +4 more
doaj   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source