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Stereocontrolled synthesis and nuclear magnetic resonance analysis of boranophosphate/phosphate chimeric oligonucleotides [PDF]

Royal Society Open Science
This report describes the stereoselective synthesis of boranophosphate/phosphate (PB/PO) chimeric oligodeoxynucleotides (ODNs) and the nuclear magnetic resonance (NMR) analysis of oligomers containing PB linkages.
Kiyoshi Kakuta, Taiichi Sakamoto, Hajime Sato, Kazuki Sato, Takeshi Wada   +4 more
doaj   +2 more sources

Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones

Molecules, 2023
The stereochemical properties of N-acyl-5H-dibenzo[b,d]azepin-7(6H)-ones (2a–c), which inhibit potassium channels in T cells, were examined by freezing their conformational change due to 4-methyl substitution.
Arisa Chiba, Ryoko Tanaka, Mayuno Hotta, Kayo Nakamura, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi   +8 more
doaj   +1 more source

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives

Molecules, 2020
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi, Antal Csámpai, Ferenc Fülöp, István Szatmári   +3 more
doaj   +1 more source

Synthesis and Oxidative Transformations of New Chiral Pinane-Type γ-Ketothiols: Stereochemical Features of Reactions

Molecules, 2021
Chiral γ-ketothiols, thioacetates, thiobenzoate, disulfides, sulfones, thiosulfonates, and sulfonic acids were obtained from β-pinene for the first time.
Olga M. Lezina, Svetlana N. Subbotina, Larisa L. Frolova, Svetlana A. Rubtsova, Denis V. Sudarikov   +4 more
doaj   +1 more source

Synthesis, Enantiomeric Resolution and Biological Evaluation of HIV Capsid Inhibition Activity for Racemic, (S)- and (R)-PF74

Molecules, 2021
PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resulted
Stuart Ruddell, Elena Sugrue, Sarah Memarzadeh, Lorna Mae Hellam, Sam J. Wilson, David J. France   +5 more
doaj   +1 more source

Ipertrofan Revisited—The Proposal of the Complete Stereochemistry of Mepartricin A and B

Molecules, 2021
Being a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic ...
Paweł Szczeblewski, Witold Andrałojć, Justyna Polit, Aneta Żabka, Konrad Winnicki, Tomasz Laskowski   +5 more
doaj   +1 more source

Synthesis and Conformational Analysis of Naphthoxazine-Fused Phenanthrene Derivatives

Molecules, 2020
The synthesis of new phenanthr[9,10-e][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified aza-Friedel–Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with ...
Khadija Belasri, Leila Topal, Matthias Heydenreich, Andreas Koch, Erich Kleinpeter, Ferenc Fülöp, István Szatmári   +6 more
doaj   +1 more source

Electron Lone-Pairs Stereochemistry and Drastic van der Waals and Pressure Effects in AsF₃ from First Principles

Condensed Matter, 2021
AsF3E as a representative of a molecular crystal has been chosen to find the precise localization of the lone pair (LP) E centroid 4s2 of As3+ and to enlighten the behavior of lone pair triplets of fluorine atoms. Starting from stereochemistry rationale,
Jean Galy, Samir F. Matar
doaj   +1 more source

Solvent-Free C-3 Coupling of Azaindoles with Cyclic Imines

Molecules, 2019
By direct coupling 7-azaindole and cyclic imines, such as 3,4-dihydroisoquinoline, 6,7-dihydrothieno[3,2-c]pyridine, 3,4-dihydro-β-carboline, and 4,5-dihydro-3H-benz[c]azepine, new 3-substituted 7-azaindole derivatives have been synthesized.
Khadija Belasri, Ferenc Fülöp, István Szatmári   +2 more
doaj   +1 more source

Stereochemistry of Astaxanthin Biosynthesis in the Marine Harpacticoid Copepod Tigriopus Californicus

Marine Drugs, 2020
The harpacticoid copepod Tigriopus californicus has been recognized as a model organism for the study of marine pollutants. Furthermore, the nutritional profile of this copepod is of interest to the aquafeed industry.
Alfonso Prado-Cabrero, Ganjar Saefurahman, John M. Nolan   +2 more
doaj   +1 more source