Results 1 to 10 of about 133,967 (336)

Stereocontrolled synthesis and nuclear magnetic resonance analysis of boranophosphate/phosphate chimeric oligonucleotides [PDF]

Royal Society Open Science
This report describes the stereoselective synthesis of boranophosphate/phosphate (PB/PO) chimeric oligodeoxynucleotides (ODNs) and the nuclear magnetic resonance (NMR) analysis of oligomers containing PB linkages.
Kiyoshi Kakuta, Taiichi Sakamoto, Hajime Sato, Kazuki Sato, Takeshi Wada   +4 more
doaj   +2 more sources

Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones

Molecules, 2023
The stereochemical properties of N-acyl-5H-dibenzo[b,d]azepin-7(6H)-ones (2a–c), which inhibit potassium channels in T cells, were examined by freezing their conformational change due to 4-methyl substitution.
Arisa Chiba, Ryoko Tanaka, Mayuno Hotta, Kayo Nakamura, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi   +8 more
doaj   +1 more source

A unique bacteriohopanetetrol stereoisomer of marine anammox [PDF]

, 2020
Anaerobic ammonium oxidation (anammox) is a major process of bioavailable nitrogen removal from marine systems. Previously, a bacteriohopanetetrol (BHT) isomer, with unknown stereochemistry, eluting later than BHT using high performance liquid ...
Alex Charlton, E., Colin Murrell, J., Farhan Ul Haque, Muhammad, Hopmans, Ellen C., Jetten, Mike S.M., Lengger, Sabine K., Martin Jones, D., Normand, Philippe, Nuijten, Guylaine H.L., Rush, Darci, Schaeffer, Philippe, Schenesse, Margot, Schwartz-Narbonne, Rachel, Sinninghe Damsté, Jaap S., Talbot, Helen M.   +14 more
core   +4 more sources

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives

Molecules, 2020
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi, Antal Csámpai, Ferenc Fülöp, István Szatmári   +3 more
doaj   +1 more source

Substrate control in stereoselective lanthionine biosynthesis. [PDF]

, 2015
Enzymes are typically highly stereoselective catalysts that enforce a reactive conformation on their native substrates. We report here a rare example in which the substrate controls the stereoselectivity of an enzyme-catalysed Michael-type addition ...
Houk, KN, Jiménez-Osés, Gonzalo, Tang, Weixin, van der Donk, Wilfred A   +3 more
core   +4 more sources

Diels–Alder reaction of β-fluoro-β-nitrostyrenes with cyclic dienes

Beilstein Journal of Organic Chemistry, 2021
The Diels–Alder reaction of β-fluoro-β-nitrostyrenes with cyclic 1,3-dienes was investigated. A series of novel monofluorinated norbornenes was prepared in up to 97% yield.
Savva A. Ponomarev, Roman V. Larkovich, Alexander S. Aldoshin, Andrey A. Tabolin, Sema L. Ioffe, Jonathan Groß, Till Opatz, Valentine G. Nenajdenko   +7 more
doaj   +1 more source

Solvent-Free C-3 Coupling of Azaindoles with Cyclic Imines

Molecules, 2019
By direct coupling 7-azaindole and cyclic imines, such as 3,4-dihydroisoquinoline, 6,7-dihydrothieno[3,2-c]pyridine, 3,4-dihydro-β-carboline, and 4,5-dihydro-3H-benz[c]azepine, new 3-substituted 7-azaindole derivatives have been synthesized.
Khadija Belasri, Ferenc Fülöp, István Szatmári   +2 more
doaj   +1 more source

Nucleophilic Substitution at Heteroatoms—Identity Substitution Reactions at Phosphorus and Sulfur Centers: Do They Proceed in a Concerted (S_N2) or Stepwise (A–E) Way?

Molecules, 2022
The mechanisms of three selected identity substitution reactions at phosphorus and sulfur occurring with stereospecific inversion have been investigated using density functional theory (DFT).
Marian Mikołajczyk, Marek Cypryk, Bartłomiej Gostyński, Jakub Kowalczewski   +3 more
doaj   +1 more source

Synthesis of cyclopropanes via organoiron methodology: stereoselective preparation of cis-2-(2’-carboxycyclopropyl)glycine [PDF]

, 2002
A stereoselective route to cis-2-(2′-carboxycyclopropyl)glycine has been developed. exo-Nucleophilic addition to the (bicyclo[5.1.0]octadienyl)iron(1+) cation establishes the relative stereochemistry at the cyclopropane ring and the α-stereocenter ...
Donaldson, William, Wallock, Nathaniel J
core   +2 more sources

Synthesis, Enantiomeric Resolution and Biological Evaluation of HIV Capsid Inhibition Activity for Racemic, (S)- and (R)-PF74

Molecules, 2021
PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resulted
Stuart Ruddell, Elena Sugrue, Sarah Memarzadeh, Lorna Mae Hellam, Sam J. Wilson, David J. France   +5 more
doaj   +1 more source