Results 1 to 10 of about 166,235 (318)

Stereochemical aspects of the nucleophilic attack in different classes of l-asparaginases [PDF]

IUCrJ
L-Asparaginases hydrolyze L-asparagine to L-aspartate with the release of ammonia. Currently, three completely unrelated structural classes of L-asparaginases are known, further subdivided into five types.
Miroslaw Gilski, Kinga Pokrywka, Mariusz Jaskolski   +2 more
doaj   +2 more sources

Stereochemistry

Definitions, 2019
The study of the spatial groups that affect the properties of atoms within molecules.
Graham Patrick
openaire   +2 more sources

Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones

Molecules, 2023
The stereochemical properties of N-acyl-5H-dibenzo[b,d]azepin-7(6H)-ones (2a–c), which inhibit potassium channels in T cells, were examined by freezing their conformational change due to 4-methyl substitution.
Arisa Chiba, Ryoko Tanaka, Mayuno Hotta, Kayo Nakamura, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi   +8 more
doaj   +1 more source

A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

Frontiers in Immunology, 2021
The resolution of the acute inflammatory response is governed by phagocytes actively clearing apoptotic cells and pathogens. Biosynthesis of the specialized pro-resolving mediators (SPMs) is pivotal in the resolution of inflammation via their roles in ...
Stephania Libreros, A. Shay, Robert Nshimiyimana, David Fichtner, Michael J. Martin, Nicholas Wourms, C. Serhan   +6 more
semanticscholar   +1 more source

Chemistry, Cyclophosphamide, Cancer Chemotherapy, and Serendipity: Sixty Years On

Substantia, 2021
Cambridge Dictionary: serendipity | noun | the phenomenon of finding interesting or valuable things by chance. The year 2019 marked the 60th anniversary of the approval of cyclophosphamide (CP) as an anticancer by the U.S.
Gerald Zon
doaj   +1 more source

Fast and Accurate Prediction of Refractive Index of Organic Liquids with Graph Machines

Molecules, 2023
The refractive index (RI) of liquids is a key physical property of molecular compounds and materials. In addition to its ubiquitous role in physics, it is also exploited to impart specific optical properties (transparency, opacity, and gloss) to ...
François Duprat, Jean-Luc Ploix, Jean-Marie Aubry, Théophile Gaudin   +3 more
doaj   +1 more source

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives

Molecules, 2020
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi, Antal Csámpai, Ferenc Fülöp, István Szatmári   +3 more
doaj   +1 more source

A global Ramachandran score identifies protein structures with unlikely stereochemistry

bioRxiv, 2020
Ramachandran plots report the distribution of the (φ, Ψ) torsion angles of the protein backbone and are one of the best quality metrics of experimental structure models. Typically, validation software reports the number of residues belonging to “outlier”,
O. Sobolev, P. Afonine, N. Moriarty, M. Hekkelman, R. Joosten, A. Perrakis, P. Adams   +6 more
semanticscholar   +1 more source

Synthesis and Conformational Analysis of Naphthoxazine-Fused Phenanthrene Derivatives

Molecules, 2020
The synthesis of new phenanthr[9,10-e][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified aza-Friedel–Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with ...
Khadija Belasri, Leila Topal, Matthias Heydenreich, Andreas Koch, Erich Kleinpeter, Ferenc Fülöp, István Szatmári   +6 more
doaj   +1 more source

A unique bacteriohopanetetrol stereoisomer of marine anammox [PDF]

, 2020
Anaerobic ammonium oxidation (anammox) is a major process of bioavailable nitrogen removal from marine systems. Previously, a bacteriohopanetetrol (BHT) isomer, with unknown stereochemistry, eluting later than BHT using high performance liquid ...
Alex Charlton, E., Colin Murrell, J., Farhan Ul Haque, Muhammad, Hopmans, Ellen C., Jetten, Mike S.M., Lengger, Sabine K., Martin Jones, D., Normand, Philippe, Nuijten, Guylaine H.L., Rush, Darci, Schaeffer, Philippe, Schenesse, Margot, Schwartz-Narbonne, Rachel, Sinninghe Damsté, Jaap S., Talbot, Helen M.   +14 more
core   +6 more sources