Results 1 to 10 of about 177,307 (324)

Stereochemistry-Controlled Mechanical Properties and Degradation in 3D-Printable Photosets

Journal of the American Chemical Society, 2021
Stereochemistry provides an appealing handle by which to control the properties of small molecules and polymers. While it is established that stereochemistry in linear polymers affects their bulk mechanical properties, the application of this concept to ...
Anissa L. Khalfa, Matthew L. Becker, Andrew P. Dove   +2 more
openalex   +3 more sources

Stereocontrolled synthesis and nuclear magnetic resonance analysis of boranophosphate/phosphate chimeric oligonucleotides [PDF]

Royal Society Open Science
This report describes the stereoselective synthesis of boranophosphate/phosphate (PB/PO) chimeric oligodeoxynucleotides (ODNs) and the nuclear magnetic resonance (NMR) analysis of oligomers containing PB linkages.
Kiyoshi Kakuta, Taiichi Sakamoto, Hajime Sato, Kazuki Sato, Takeshi Wada   +4 more
doaj   +2 more sources

Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT

Journal of the American Chemical Society, 2022
Lanthipeptides are polycyclic peptides characterized by the presence of lanthionine (Lan) and/or methyllanthionine (MeLan). They are members of the ribosomally synthesized and post-translationally modified peptides (RiPPs).
Raymond Sarksian, J. Hegemann, M. Simon, J. Acedo, W. A. van der Donk   +4 more
semanticscholar   +1 more source

A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

Frontiers in Immunology, 2021
The resolution of the acute inflammatory response is governed by phagocytes actively clearing apoptotic cells and pathogens. Biosynthesis of the specialized pro-resolving mediators (SPMs) is pivotal in the resolution of inflammation via their roles in ...
Stephania Libreros, A. Shay, Robert Nshimiyimana, David Fichtner, Michael J. Martin, Nicholas Wourms, C. Serhan   +6 more
semanticscholar   +1 more source

Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones

Molecules, 2023
The stereochemical properties of N-acyl-5H-dibenzo[b,d]azepin-7(6H)-ones (2a–c), which inhibit potassium channels in T cells, were examined by freezing their conformational change due to 4-methyl substitution.
Arisa Chiba, Ryoko Tanaka, Mayuno Hotta, Kayo Nakamura, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi   +8 more
doaj   +1 more source

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives

Molecules, 2020
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi, Antal Csámpai, Ferenc Fülöp, István Szatmári   +3 more
doaj   +1 more source

Synthesis and Oxidative Transformations of New Chiral Pinane-Type γ-Ketothiols: Stereochemical Features of Reactions

Molecules, 2021
Chiral γ-ketothiols, thioacetates, thiobenzoate, disulfides, sulfones, thiosulfonates, and sulfonic acids were obtained from β-pinene for the first time.
Olga M. Lezina, Svetlana N. Subbotina, Larisa L. Frolova, Svetlana A. Rubtsova, Denis V. Sudarikov   +4 more
doaj   +1 more source

Synthesis, Enantiomeric Resolution and Biological Evaluation of HIV Capsid Inhibition Activity for Racemic, (S)- and (R)-PF74

Molecules, 2021
PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resulted
Stuart Ruddell, Elena Sugrue, Sarah Memarzadeh, Lorna Mae Hellam, Sam J. Wilson, David J. France   +5 more
doaj   +1 more source

A global Ramachandran score identifies protein structures with unlikely stereochemistry

bioRxiv, 2020
Ramachandran plots report the distribution of the (φ, Ψ) torsion angles of the protein backbone and are one of the best quality metrics of experimental structure models. Typically, validation software reports the number of residues belonging to “outlier”,
O. Sobolev, P. Afonine, N. Moriarty, M. Hekkelman, R. Joosten, A. Perrakis, P. Adams   +6 more
semanticscholar   +1 more source

Synthesis and Conformational Analysis of Naphthoxazine-Fused Phenanthrene Derivatives

Molecules, 2020
The synthesis of new phenanthr[9,10-e][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified aza-Friedel–Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with ...
Khadija Belasri, Leila Topal, Matthias Heydenreich, Andreas Koch, Erich Kleinpeter, Ferenc Fülöp, István Szatmári   +6 more
doaj   +1 more source