Results 141 to 150 of about 58,537 (265)

Engineering Polyketide Stereocenters with Ketoreductase Domain Exchanges. [PDF]

J Am Chem Soc
Keiser LS, Gatenil PP, Zhu Y, Deng K, Waldburger L, Gin JW, Chen Y, Baidoo EEK, Petzold CJ, Lanclos N, Northen TR, Englund E, Keasling JD.   +12 more
europepmc   +1 more source

Rapid Structural Analysis of Natural Products Using MicroED

Small, EarlyView.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

Major Cat Allergen Fel d 4: Structure and Identification of a Cross‐Reactive IgE‐Epitope‐Containing Area

Allergy, EarlyView.
This study reports the three‐dimensional structure of an important cat allergen, Fel d 4, that shares high homology with Equ c 1 (i.e., major horse allergen) and Can f 6 (i.e., dog allergen). The C‐terminal region of the Fel d 4 contains a major IgE‐reactive epitope.
Nikolina Todorović, Daria Trifonova, Zicheng Liu, Mirela Curin, Laszlo Schooltink, Theo Sagmeister, Christoph Grininger, Renata Kiss, Nina Gottstein, Bernd Gesslbauer, Andreas Winkler, Tea Pavkov‐Keller, Alexander Karaulov, Rudolf Valenta, Walter Keller   +14 more
wiley   +1 more source

Transamination stereochemistry in the formation of neosamine C of ribostamycin.

, 1983
Shizuko Kakinuma, SHIGEMI YAMAYA
openalex   +2 more sources

Ultrasound-Triggered Self-Assembly of Discrete Oligourethanes into Supramolecular Gels: Importance of Stereocenter Sequence. [PDF]

ACS Macro Lett
Castellanos E, Dudziak W, Groch P, Szuwarzyński M, Szweda R.   +4 more
europepmc   +1 more source

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, EarlyView.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source

Author Correction: Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide. [PDF]

Nat Commun
Kongstad KT, Hansen NL, Kjaerulff L, Heck QK, Forman V, Staerk D, Møller BL, Andersen-Ranberg J.   +7 more
europepmc   +1 more source

The Preparation and Dynamic Stereochemistry of Oxyarsoranes Containing Five- and Six-membered Ring Systems. [PDF]

, 1975
Arild J. Dale, Paul Frøyen, Mona Grönlund, Anna‐Britta Hörnfeldt, Rolf Servin, Hans Sternerup   +5 more
openalex   +1 more source

Structural analysis of the NifL‐NifA complex reveals the molecular basis of anti‐activation of nitrogen fixation gene expression in Azotobacter vinelandii

The FEBS Journal, EarlyView.
Using cryo‐EM combined with biochemical and genetic approaches, we mapped the interaction surface between NifL and NifA to gain insights into the regulation of nitrogen fixation genes in A. vinelandii. Our findings suggest that NifL, a homolog of histidine kinases lacking phosphorylation activity, evolved to act as a steric block of NifA activity ...
Marcelo Bueno Batista, Jake Richardson, Michael W. Webster, Dmitry Ghilarov, John W. Peters, David M. Lawson, Ray Dixon   +6 more
wiley   +1 more source

Stereochemistry Drives the Macromolecular Conformation and Biological Activity of Glycopolymers. [PDF]

ACS Cent Sci
Ishaq MW, Farzeen P, Vaughn LR, Stone DJ, Deshmukh SA, Callmann CE.   +5 more
europepmc   +1 more source