Results 151 to 160 of about 177,307 (324)

Bioprospecting of Labdane‐Type Diterpenes From Austroeupatorium laetevirens: Molecular Networking, Structural Elucidation, and Biological Activity Evaluation

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Labdane‐type diterpenes are the main specialized metabolites in the Austroeupatorium genus, known for diverse biological activities. This study employed molecular networking to facilitate the identification of labdanes in Austroeupatorium laetevirens, alongside isolation, structural elucidation, and evaluation of anti‐Mycobacterium ...
Francielli A. P. Valeze   +13 more
wiley   +1 more source

Synthesis of the Abiraterone Derivatives 5α‐ and 5β‐Δ1‐Abiraterone and Structural Determination of an Unknown Metabolite in Human Serum Derived from Oral Abiraterone Acetate

open access: yesChemBioChem, EarlyView.
Abiraterone (Abi) acetate, a prostate cancer treatment, is orally administered and hydrolyzed, and multiple metabolites are produced in serum by various enzymes. Two novel Abi derivatives, 5α‐ and 5β‐Δ1‐abiraterone, are synthesized. Then, an unknown metabolite in serum is identified to be 5β‐Δ1‐abiraterone based on its extracted ion chromatogram ...
Noboru Hayama   +7 more
wiley   +1 more source

Shedding Light on the Precatalytic Mixture of Pd(OAc)2 and Cooperating Bipyridone Ligands for the C─H Functionalization of Arenes

open access: yesChemCatChem, EarlyView.
The reactions of the common palladium precursors Pd(OAc)2 and PdCl2 and cooperating bipyridone ligands leads to well defined complexes which are general precatalysts for the direct C─H arylation of arenes, more active than Pd(OAc)2/ligand mixtures in nonpolar solvents.
Francisco Villalba   +2 more
wiley   +1 more source

Stereochemistry and Validation of Macromolecular Structures.

open access: yesMethods in molecular biology, 2017
A. Wlodawer
semanticscholar   +1 more source

Selective N‐Alkylation of Unprotected Amino Sugars by Alcohols. Application to the Synthesis of Sugar‐Based Surfactants

open access: yesChemistryEurope, EarlyView.
A borrowing hydrogen strategy using an NHC‐Ir(III) catalyst enables selective N‐functionalization of unprotected amino sugars using alcohols as alkylating agents. The use of unprotected substrates avoids extra steps of protection/deprotection, minimizing waste generation.
Aitor Bermejo‐López   +7 more
wiley   +1 more source

Imidazoline‐Proline and Imidazoline‐Prolinate Ligands for Copper‐Catalyzed Asymmetric Exo‐Selective [3 + 2] Cycloaddition of Iminoesters with Nitroalkenes

open access: yesChemistryEurope, EarlyView.
From a modular synthesis of nonphosphine chiral nitrogen‐based chiral imidazoline–amino acid ligands, two new chiral imidazoline–proline‐copper catalysts are developed for targeting exo‐selective [3 + 2] cycloaddition reaction. Density functional theory studies rationalize the observed stereoselectivity and the distinct chiral pockets of the two ...
Yan Yu   +4 more
wiley   +1 more source

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