Isolation, structure revision and stereochemistry of trichomycins A and B, aromatic analogues of amphotericin B [PDF]
Tomasz Laskowski +8 more
openalex +1 more source
Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context
Evolutionary gains and losses of key biosynthetic genes likely resulting from multiple independent evolutionary events explain why certain Nepeta (catnip) species produce both the active, cat‐attracting nepetalactones and sugar‐bound iridoids, while others make only the sugar‐bound forms, and some have lost iridoid production entirely.
Tijana Banjanac +15 more
wiley +1 more source
CANDID-CNS: AI Unlocks Stereochemistry and Beyond Rule of 5 to Predict CNS Penetration of Small Molecules. [PDF]
Collins JW +5 more
europepmc +1 more source
A Plant‐Based Platform for the Production of Bark Beetle Pheromones
ABSTRACT Bark beetle species of the genera Ips and Dendroctonus represent a threat to forests in both North America and Europe. Under normal circumstances, these beetles recycle dying trees into nutrients, but under certain conditions, growing populations can overcome healthy tree defenses and cause severe economic loss in forestry.
Abraham Ontiveros‐Cisneros +7 more
wiley +1 more source
Terpenes as Naturally Occurring Stereochemical Templates: Conformationally Driven Discovery of Reactivity. [PDF]
Arto O +6 more
europepmc +1 more source
Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum
ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Jongbu Lim +16 more
wiley +1 more source
Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes
An asymmetric intramolecular hydride shift reaction has been developed that is catalyzed by Al Lewis acids in conjunction with a chiral BINOL‐derived ligand. Racemic THP substrates are transformed into cyclohexene products via an intermediate prochiral enone; which undergoes a key 1,5‐hydride shift reaction.
Mostafa M. Amer +4 more
wiley +2 more sources
Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion. [PDF]
Hwang J +21 more
europepmc +1 more source
Highlights from the 43rd EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, April 2008
Scott L. Cockroft, David M. Lindsay
openalex +2 more sources

