Results 171 to 180 of about 177,307 (324)

Engineering Polyketide Stereocenters with Ketoreductase Domain Exchanges. [PDF]

J Am Chem Soc
Keiser LS, Gatenil PP, Zhu Y, Deng K, Waldburger L, Gin JW, Chen Y, Baidoo EEK, Petzold CJ, Lanclos N, Northen TR, Englund E, Keasling JD.   +12 more
europepmc   +1 more source

Acyclic Nucleoside Phosphonates As Potential Inhibitors Of Plasmodium Falciparum Egress

Chemistry – A European Journal, EarlyView.
Exploration of the chemistry of acyclic nucleoside phosphonates allowed us to study structural diversity from the hit compound; biological evaluation and molecular docking were performed to decipher key interactions with the putative target. Abstract The emergence of drug‐resistant Plasmodium strains requires the development of novel antimalarial ...
Thomas Cheviet, Sharon Wein, Corinne Lionne, Yan Badji, Natacha Venturini, Rachel Cerdan, Suzanne Peyrottes   +6 more
wiley   +1 more source

Author Correction: Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide. [PDF]

Nat Commun
Kongstad KT, Hansen NL, Kjaerulff L, Heck QK, Forman V, Staerk D, Møller BL, Andersen-Ranberg J.   +7 more
europepmc   +1 more source

Synthesis and determination of absolute stereochemistry of Gosodesmine

Mir Mohd Ikhlaq, Nguyen Ngoc Thanh Luan, Takuya Okada, Naoki Toyooka   +3 more
openalex   +1 more source

Development of Synthetic Routes to 2′‐O,4′‐C‐Spirocyclopentylene‐Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine

Chemistry – A European Journal, EarlyView.
A novel synthetic route to 2′‐O,4′‐C‐spirocyclopentylene‐bridged nucleic acid (scpBNA2) monomers bearing thymine, guanine, and adenine nucleobases. The strategy integrates 2′,4′‐lactonization, transglycosylation, and intramolecular iodocyclization, thereby bypassing the 2′‐OH inversion step and providing scpBNA2 nucleoside building blocks for antisense
Riku Kumagai, Riko Yamada, Takao Yamaguchi, Satoshi Obika   +3 more
wiley   +1 more source

Stereochemistry Drives the Macromolecular Conformation and Biological Activity of Glycopolymers. [PDF]

ACS Cent Sci
Ishaq MW, Farzeen P, Vaughn LR, Stone DJ, Deshmukh SA, Callmann CE.   +5 more
europepmc   +1 more source

Regio‐ and Stereocontrolled‐Synthesis of a Heterocycle Fragment Collection Using Palladium Catalyzed C‐H Arylation

Chemistry – A European Journal, EarlyView.
44 novel heterocycle fragments are prepared through a C–H functionalization strategy. Systematic variation of exit vectors and polar functionality provides a set of fragments that sit in attractive fragment chemical space. Abstract Saturated heterocycles are valuable fragments in drug discovery due to their polarity, 3D structure, and potential for ...
Amalia‐Sofia Piticari, Daniele Antermite, Harry J. Linkhorn, Natalia A. Larionova, Matthew P. Webster, James A. Bull   +5 more
wiley   +1 more source

De Novo Design and Asymmetric Synthesis of a <i>C</i>-1/2 Benzodioxin Fused Glycoside Analogue of Lincomycin. [PDF]

Org Lett
Hicks I, Moradei R, Chiaraviglio L, Aljahdali AZ, Donthiri RR, Kirby JE, O'Doherty GA.   +6 more
europepmc   +1 more source

Enantiospecific, Regioselective Cross-Coupling Reactions of Secondary Allylic Boronic Esters [PDF]

, 2013
Aggarwal, Varinder K., Chausset-Boissarie, Laetitia, Chen, Jack L. -Y., Crudden, Cathleen M., Ghozati, Kazem, LaBine, Emily   +5 more
core   +1 more source

Absolute Stereochemistries of Sylvaticin and 12,15-cis-Sylvaticin, Bioactive C-20,23-cis Non-adjacent Bistetrahydrofuran Annonaceous Acetogenins, from Rollinia mucosa

, 1995
Jerry L. McLaughlin, Guoen Shi, Lu Zeng, Zhe-ming Gu, John M. MacDougal   +4 more
openalex   +1 more source