Results 21 to 30 of about 58,537 (265)

Mechanism-based Enzyme Inactivators of Phytosterol Biosynthesis

Molecules, 2004
Current progress on the mechanism and substrate recognition by sterol methyl transferase (SMT), the role of mechanism-based inactivators, other inhibitors of SMT action to probe catalysis and phytosterol synthesis is reported.
W. David Nes, Mathew B. Miller, Phani Veeramachanemi, Archana Sinha, Pruthvi Jayasimha, Jialin Liu, Ragu Kanagasabai, Zhihong Song, Wenxu Zhou   +8 more
doaj   +1 more source

Amino Alcohols from the Ascidian Pseudodistoma sp.

Marine Drugs, 2014
Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea.
Tae Hyung Won, Minjung You, So-Hyoung Lee, Boon Jo Rho, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin   +6 more
doaj   +1 more source

Teaching Stereochemistry with Multimedia and Hands-On Models: The Relationship between Students’ Scientific Reasoning Skills and The Effectiveness of Model Type

Center for Educational Policy Studies Journal
This paper presents an analysis of the use of multimedia and hands-on models on university students’ understanding of stereochemistry. The relationship between students’ scientific reasoning skills and their understanding of stereochemistry was also ...
Rooserina Kusumaningdyah, Iztok Devetak, Yudhi Utomo, Effendy Effendy, Daratu Putri, Habiddin Habiddin   +5 more
doaj   +1 more source

The C–F bond as a conformational tool in organic and biological chemistry

Beilstein Journal of Organic Chemistry, 2010
Organofluorine compounds are widely used in many different applications, ranging from pharmaceuticals and agrochemicals to advanced materials and polymers.
Luke Hunter
doaj   +1 more source

Nucleophilic Substitution at Heteroatoms—Identity Substitution Reactions at Phosphorus and Sulfur Centers: Do They Proceed in a Concerted (S_N2) or Stepwise (A–E) Way?

Molecules, 2022
The mechanisms of three selected identity substitution reactions at phosphorus and sulfur occurring with stereospecific inversion have been investigated using density functional theory (DFT).
Marian Mikołajczyk, Marek Cypryk, Bartłomiej Gostyński, Jakub Kowalczewski   +3 more
doaj   +1 more source

How and How Much Molecular Conformation Affects Electronic Circular Dichroism: The Case of 1,1-Diarylcarbinols

Molecules, 2018
Chiroptical spectra such as electronic circular dichroism (ECD) are said to be much more sensitive to conformation than their non-chiroptical counterparts, however, it is difficult to demonstrate such a common notion in a clear-cut way.
Daniele Padula, Gennaro Pescitelli
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Insights into the Phytochemistry of the Cuban Endemic Medicinal Plant Phyllanthus orbicularis: Fideloside, a Novel Bioactive 8-C-glycosyl 2,3-Dihydroflavonol

Molecules, 2019
Phyllanthus orbicularis (Phyllanthaceae) is an endemic evergreen tropical plant of Cuba that grows in the western part of the island and is used in traditional medicine as an infusion.
Antonio Francioso, Katrin Franke, Claudio Villani, Luciana Mosca, Maria D’Erme, Stefan Frischbutter, Wolfgang Brandt, Angel Sanchez-Lamar, Ludger Wessjohann   +8 more
doaj   +1 more source

Unravelling the Atomic Structure of a Metal‐Covalent Organic Framework Assembled from Ruthenium Metalloligands

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
Metal‐covalent organic frameworks (MCOFs) are novel porous materials that exhibit the advantages of covalent and metal‐organic frameworks. However, it is extremely difficult to resolve their atomic structure and better understand their structure‐properties relation. This work utilizes a synergistic combination of advanced microscopy, spectroscopic, and
Seán Hennessey, Roberto González‐Gómez, Nicolás Arisnabarreta, Anna Ciotti, Jing Hou, Nadezda V. Tarakina, Andrey Bezrukov, Kunal S. Mali, Michael Zaworotko, Steven De Feyter, Max García‐Melchor, Pau Farràs   +11 more
wiley   +1 more source