Results 21 to 30 of about 176,257 (369)
Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution [PDF]
, 2003 Aldolases have potential as tools for the synthesis of stereochemically complex carbohydrates. Here, we show that directed evolution can be used to alter the stereochemical course of the reaction catalyzed by tagatose-1,6-bisphosphate aldolase.
A. Berry +27 more
core +2 more sources
Mannich base-connected syntheses mediated by ortho-quinone methides
Beilstein Journal of Organic Chemistry, 2018 This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate.
Petra Barta +2 more
doaj +1 more source
Journal of Chemical Information and Modeling, 2019 There is a renewed interest in computer-aided synthesis planning, where the vast majority of approaches require the application of retrosynthetic reaction templates.
Connor W. Coley, W. Green, K. Jensen
semanticscholar +1 more source
Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer [PDF]
, 2015 Chiral, dimeric natural products containing complex structures and interesting biological properties have inspired chemists and biologists for decades.
A Zask +53 more
core +2 more sources
The Stereochemistry of Ketoreduction [PDF]
Chemistry & Biology, 2005 In this issue of Chemistry & Biology, Leadlay and coworkers report overproduction of a number of ketoreductase domains from modular polyketide synthases. These discrete enzymes allow the stereochemistry of polyketide ketoreduction to be studied in isolation.
openaire +3 more sources
X-ray Diffraction, Electronic Circular Dichroism, and Quantum Mechanics (TD-DFT) Investigations on 4 Dehydroxyaltersolanol A, a Secondary Metabolite from Endophytic Fungus Nigrospora oryzae [PDF]
Research Journal of PharmacognosyBackground and objectives: A tetrahydro anthraquinone derivative, 4-dehydroxyaltersolanol A, has been obtained from Nigrospora oryzae, which was isolated from Uncaria borneensis Havil as an endophytic fungus.
Fatimah Bebe Mohamed Hussain +8 more
doaj +1 more source
New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle
Marine Drugs, 2023 Fifteen new diterpenoids, namely xishaklyanes A-O (1–15), along with three known related ones (16–18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea.
Jia-Dong Yu +5 more
doaj +1 more source
Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]
, 2015 MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng +6 more
core +2 more sources
Marine Drugs, 2022 NMR data prediction is increasingly important in structure elucidation. The impact of force field selection was assessed, along with geometry and energy cutoffs.
Cristina Cuadrado +2 more
doaj +1 more source