Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects [PDF]
Frontiers in ChemistryDihydroquercetin (DHQ) is a representative of flavonoids that is available on the market as a food supplement and registered as an active pharmaceutical ingredient.
Roman P. Terekhov +9 more
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Frontiers in Pharmacology, 2022 The complexity of chemical components of herbal medicines often causes great barriers to toxicity research. In our previous study, we have found the critical divergent hepatotoxic potential of a pair of stilbene isomers in a famous traditional Chinese ...
Juan Liu +12 more
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Orbital: The Electronic Journal of Chemistry, 2018 Pyrethroids are chiral insecticides characterized by stereoisomerism, which occurs due to the presence of one to three asymmetric (chiral) carbons, generating one or two pairs of cis/trans diastereomers, and two or four pairs of enantiomers ...
Cláudio Ernesto Taveira Parente +3 more
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Stereochemically-aware bioactivity descriptors for uncharacterized chemical compounds [PDF]
Journal of CheminformaticsStereochemistry plays a fundamental role in pharmacology. Here, we systematically investigate the relationship between stereoisomerism and bioactivity on over 1 M compounds, finding that a very significant fraction (~ 40%) of spatial isomer pairs show ...
Arnau Comajuncosa-Creus +4 more
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Stereoisomerism in Nanohoops with Heterogeneous Biaryl Linkages of E/Z- and R/S-Geometries
ACS Central Science, 2016 The stereochemistry of cycloarylene nanohoops gives rise to unique cyclostereoisomerism originating from hoop-shaped molecular shapes. However, cyclostereoisomerism has not been well understood despite the ever-increasing number of structural variants ...
Parantap Sarkar +5 more
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Preclinical characterisation of gallium-68 labeled ferrichrome siderophore stereoisomers for PET imaging applications [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Siderophores are small iron-binding molecules produced by microorganisms to facilitate iron acquisition from the environment. Radiolabelled siderophores offer a promising solution for infection imaging, as they can specifically target the ...
Kristyna Krasulova +6 more
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Alkali cation-π interactions in aqueous systems, modulating supramolecular stereoisomerism of nanoscopic metal-organic capsules [PDF]
Nature CommunicationsContrary to common chemical intuition, cation-π interactions can persist in polar, aqueous reaction solutions, rather than in dry non-coordinative solvent systems.
Paul Wix +8 more
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Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase [PDF]
Frontiers in Pharmacology, 2023 The epidermal growth factor receptor (EGFR) plays a crucial role in regulating cellular growth and survival, and its dysregulation is implicated in various cancers, making it a prime target for cancer therapy.
Mohd Rehan +12 more
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Clinical Pharmacokinetics of Fexofenadine: A Systematic Review [PDF]
PharmaceuticsBackground/Objectives: Fexofenadine hydrochloride is a widely prescribed drug for treating histamine-mediated allergic reactions. This review systematically collates existing research on the clinical pharmacokinetics (PK) of fexofenadine, with a copious ...
Maryam Batool +5 more
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Efficacy of Different Doses of Cisatracurium for Intubation during Surgeries under General Anaesthesia- A Randomised Clinical Study [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Cisatracurium is a new non depolarising, Neuromuscular Blocking Drug (NMBD) with fast onset and short duration of action. It is a stereoisomer of atracurium with a potency of approximately three to four times greater than that of atracurium.
Sana Ahmed Shaikh +3 more
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