Results 121 to 130 of about 36,653 (344)

Comparative Study Related to Cardiovascular Safety between Bupivacaine (S75-R25) and Ropivacaine in Brachial Plexus Block

open access: yesBrazilian Journal of Anesthesiology, 2013
Background and objectives Bupivacaine is a first choice for regional anesthesia considering its effectiveness, long duration and less motor blockade.
Adilson Hamaji   +4 more
doaj  

Laboratory classes in bioorganic chemistry [PDF]

open access: yes, 2013
биоорганическая химияЛабораторные занятия предназначены для иностранных студентов и включают 18 ...
Hidranovich, L. G., Khodos, O. A.
core  

Mono‐ IrIII versus heterobimetallic IrIII‐AuI complexes for circularly polarized luminescence

open access: yesChemistry – A European Journal, Accepted Article.
Fundamental rationalization of the structural–circularly polarized luminescence (CPL) activity relationship is a challenging task. Herein, a pair of enantiopure, heterobimetallic IrIII–AuI complexes IrAu‐4 featuring chirality‐at‐metal is thoroughly investigated by means of spectroscopical and computational techniques, also including spin‐orbital ...
Lavinia Ballerini   +9 more
wiley   +1 more source

Using Systemic Problem Solving (SPS) to Assess Student Achievement in Chemistry [PDF]

open access: yes, 2012
This paper focuses on the uses of systemic problem solving in chemistry at the tertiary level. Traditional problem solving (TPS) is a useful tool to help teachers examine recall of information, comprehension, and application.
Fahmy, AFM, Lagowski, JJ
core   +1 more source

Double‐Click Strategy Combining CuAAC and (Thia‐) Diels‐Alder Reactions; Application towards Peptide Labeling

open access: yesChemistry – A European Journal, Accepted Article.
We report an efficient double‐click strategy combining copper‐catalyzed azide–alkyne cycloaddition (CuAAC) with (thia‐)Diels–Alder (DA) reactions, enabled by newly designed heterobifunctional platforms bearing orthogonal clickable groups: alkyne–dithioester, alkyne–maleimide, or azide–diene.
Timothé Maujean   +7 more
wiley   +1 more source

Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization

open access: yesChemMedChem, EarlyView.
A multitier computational strategy discovers potential USP7 inhibitors using similarity‐based virtual screening, physics‐driven molecular simulations, binding free energy estimations, binary QSAR modeling, and steered molecular dynamics analysis. This integrated approach prioritizes and optimizes lead compounds with strong predicted affinity, offering ...
Ehsan Sayyah   +2 more
wiley   +1 more source

Development and \u3cem\u3eIn Silico\u3c/em\u3e Evaluation of Large-Scale Metabolite Identification Methods Using Functional Group Detection for Metabolomics [PDF]

open access: yes, 2014
Large-scale identification of metabolites is key to elucidating and modeling metabolism at the systems level. Advances in metabolomics technologies, particularly ultra-high resolution mass spectrometry (MS) enable comprehensive and rapid analysis of ...
Fan, Teresa W-M   +3 more
core   +1 more source

Nucleophilic Fluorination of a Secondary Alkyl Bromide with KF(18‐Crown‐6) and Bulky Diols: Microsolvation Causes Chemoselectivity Inversion in the Free Energy Profile

open access: yesChemPlusChem, EarlyView.
The combination of crown ether with strong hydrogen bond donor bulky diols enhances reactivity and SN2 selectivity in challenging fluorination reactions of secondary alkyl bromide substrates. Fluoride ion solvated in polar aprotic solvents works like bases and reacts with secondary alkyl bromide substrates mainly via E2 reactions, with minor formation ...
Luís F. Resende   +2 more
wiley   +1 more source

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