Background and objectives Bupivacaine is a first choice for regional anesthesia considering its effectiveness, long duration and less motor blockade.
Adilson Hamaji+4 more
doaj
Laboratory classes in bioorganic chemistry [PDF]
биоорганическая химияЛабораторные занятия предназначены для иностранных студентов и включают 18 ...
Hidranovich, L. G., Khodos, O. A.
core
Mono‐ IrIII versus heterobimetallic IrIII‐AuI complexes for circularly polarized luminescence
Fundamental rationalization of the structural–circularly polarized luminescence (CPL) activity relationship is a challenging task. Herein, a pair of enantiopure, heterobimetallic IrIII–AuI complexes IrAu‐4 featuring chirality‐at‐metal is thoroughly investigated by means of spectroscopical and computational techniques, also including spin‐orbital ...
Lavinia Ballerini+9 more
wiley +1 more source
Using Systemic Problem Solving (SPS) to Assess Student Achievement in Chemistry [PDF]
This paper focuses on the uses of systemic problem solving in chemistry at the tertiary level. Traditional problem solving (TPS) is a useful tool to help teachers examine recall of information, comprehension, and application.
Fahmy, AFM, Lagowski, JJ
core +1 more source
We report an efficient double‐click strategy combining copper‐catalyzed azide–alkyne cycloaddition (CuAAC) with (thia‐)Diels–Alder (DA) reactions, enabled by newly designed heterobifunctional platforms bearing orthogonal clickable groups: alkyne–dithioester, alkyne–maleimide, or azide–diene.
Timothé Maujean+7 more
wiley +1 more source
Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization
A multitier computational strategy discovers potential USP7 inhibitors using similarity‐based virtual screening, physics‐driven molecular simulations, binding free energy estimations, binary QSAR modeling, and steered molecular dynamics analysis. This integrated approach prioritizes and optimizes lead compounds with strong predicted affinity, offering ...
Ehsan Sayyah+2 more
wiley +1 more source
Enhancement of Iron Absorption From Ligated Segments of Rat Intestine by Histidine, Cysteine, and Lysine: Effects of Removing Ionizing Groups and of Stereoisomerism [PDF]
Darrell Van Campen
openalex +1 more source
Development and \u3cem\u3eIn Silico\u3c/em\u3e Evaluation of Large-Scale Metabolite Identification Methods Using Functional Group Detection for Metabolomics [PDF]
Large-scale identification of metabolites is key to elucidating and modeling metabolism at the systems level. Advances in metabolomics technologies, particularly ultra-high resolution mass spectrometry (MS) enable comprehensive and rapid analysis of ...
Fan, Teresa W-M+3 more
core +1 more source
The combination of crown ether with strong hydrogen bond donor bulky diols enhances reactivity and SN2 selectivity in challenging fluorination reactions of secondary alkyl bromide substrates. Fluoride ion solvated in polar aprotic solvents works like bases and reacts with secondary alkyl bromide substrates mainly via E2 reactions, with minor formation ...
Luís F. Resende+2 more
wiley +1 more source
Bioaccumulation of Highly Hydrophobic Organohalogen Flame Retardants from Sediments: Application of Toxicokinetics and Passive Sampling Techniques [PDF]
Li, Huizhen+5 more
core +1 more source