Results 161 to 170 of about 17,928 (220)

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, Volume 368, Issue 2, January 2026.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

The End of the Beginning of Mechanical Stereochemistry. [PDF]

Acc Chem Res
Goldup SM.
europepmc   +1 more source

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, Volume 13, Issue 2, 9 January 2026.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

Asymmetric Conjugate Hydrocyanation of α,β-Unsaturated Aldehydes Catalyzed by Engineered 2-Deoxy-D-ribose-5-phosphate Aldolase. [PDF]

Chemistry
Zhou H, Fodran P, Fu H, Poelarends GJ.
europepmc   +1 more source

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

BioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi, Margherita Turrini, Francesco Cei, Marta Menicatti, Gianluca Bartolucci, Amedeo Amedei   +5 more
wiley   +1 more source

A Foldaxane-Based Supramolecular Muscle-Like Switch. [PDF]

ChemistryOpen
Waelès P, Coutrot F.
europepmc   +1 more source

Synthesis and chromatographic separation of the stereoisomers of furnidipine

, 1993
Ramón Alajarı́n, Julio Álvarez‐Buílla, Juan J. Vaquero, Carlos Sunkel, Miguel Fau de Casa-Juana, Peter R. Statkow, J. Sanz‐Aparicio   +6 more
openalex   +2 more sources

Manganese‐Induced Production of Antioxidant Polyene Steroids in the Extremophile Fungus Talaromyces fuscoviridis Isolated From Copper‐Mine Soil

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The fungus Talaromyces fuscoviridis was isolated from soil collected in a copper‐mine tailings basin in Pará State, Brazil, an extreme environment that can induce the production of bioactive secondary metabolites. Extracts and fractions obtained after cultivation were analyzed by liquid chromatography coupled to high‐resolution mass ...
Mauricio Augusto Pinto Moreno da Silva Alves, Alef dos Santos, Eduardo Jorge Pilau, Pedro Henrique de Oliveira Santiago, Javier Alcides Ellena, Marilene Nunes Oliveira, Edson Rodrigues Filho   +6 more
wiley   +1 more source

Preparation of Cycloalkano[c]pyridazinoens and Cycloalkane-condensed Pyrrolo[1,2-a]imidazolone, -pyrimidinone and -[1,3]diazepinone Stereoisomers

, 1997
G. BERNÁTH, Ferenc Csende, Zsolt Böcskei, Pàl Sohár, Géza Stájer   +4 more
openalex   +1 more source

A Robust Bioprocess for the Global Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts Produces Labeled Proteins at the Gram Scale

ChemBioChem, Volume 27, Issue 1, January 2026.
A robust bioprocess enables global incorporation of noncanonical amino acids in both shake flask and bioreactor cultures, producing gram‐per‐liter titers of efficiently labeled proteins. A versatile Escherichia coli BL21(DE3) auxotroph platform supports broad compatibility with various noncanonical amino acids and target proteins, facilitating flexible
Patrik Fladischer, Niklaus Anderhuber, Octavian Murgu, Altijana Hromić‐Jahjefendić, Tea Pavkov‐Keller, Karl Gruber, Juergen Mairhofer, Gerald Striedner, Birgit Wiltschi   +8 more
wiley   +1 more source