Results 21 to 30 of about 20,087 (300)

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

open access: yes, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Arroyo de Prada, Nuria   +10 more
core   +1 more source

Stereoisomerism and Conformational Directionality (Prelog Lecture)

open access: yesCHIMIA, 1986
The inaugural Prelog Lecture provides me with a unique opportunity to pay tribute to a great scientist, teacher, and friend. As I hope to show, the work of Vladimir Prelog is profoundly relevant to the work that I want to describe today.
Kurt Mislow
doaj   +1 more source

Stereoselective formation of bismuth complexes by transmetalation of lead with adaptable overhanging carboxylic acid 5,10-strapped porphyrins

open access: yesComptes Rendus. Chimie, 2021
Out-of-plane deformations of metalloporphyrin skeletons have been well documented as playing important roles in relevant biological processes. In contrast, out-of-plane binding to the N-core of large metal cations as period 6 post-transition elements has
Barakat, Wael   +5 more
doaj   +1 more source

The role of stereochemistry of antibiotic agents in the development of antibiotic resistance in the environment

open access: yesEnvironment International, 2020
Antibiotic resistance (ABR) is now recognised as a serious global health and economic threat that is most efficiently managed via a ‘one health’ approach incorporating environmental risk assessment.
Felicity C.T. Elder   +4 more
doaj   +1 more source

Hepatic Organoid-Based High-Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines

open access: yesFrontiers in Pharmacology, 2022
The complexity of chemical components of herbal medicines often causes great barriers to toxicity research. In our previous study, we have found the critical divergent hepatotoxic potential of a pair of stilbene isomers in a famous traditional Chinese ...
Juan Liu   +12 more
doaj   +1 more source

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

open access: yes, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D.   +2 more
core   +2 more sources

Computational exploration of the chemical structure space of possible reverse tricarboxylic acid cycle constituents [PDF]

open access: yes, 2017
The reverse tricarboxylic acid (rTCA) cycle has been explored from various standpoints as an idealized primordial metabolic cycle. Its simplicity and apparent ubiquity in diverse organisms across the tree of life have been used to argue for its antiquity
Fabienne d'Arripe-Longueville   +3 more
core   +7 more sources

Analysis of cis-isomer-enriched dihydroquercetin sample by 1D and 2D NMR spectroscopy

open access: yesРазработка и регистрация лекарственных средств
Introduction. The structure of dihydroquercetin (DHQ) is characterized by two chiral centers at positions 2 and 3 of the benzopyran cycle, resulting in possible diastereomers: trans- and cis-isomers.
R. P. Terekhov   +5 more
doaj   +1 more source

Reversible Parahydrogen Induced Hyperpolarization of 15N in Unmodified Amino Acids Unraveled at High Magnetic Field

open access: yesAdvanced Science, 2023
Amino acids (AAs) and ammonia are metabolic markers essential for nitrogen metabolism and cell regulation in both plants and humans. NMR provides interesting opportunities to investigate these metabolic pathways, yet lacks sensitivity, especially in case
Ewoud Vaneeckhaute   +4 more
doaj   +1 more source

Chiral Bifacial Non‐Fullerene Acceptors with Chirality‐Induced Spin Selectivity: A Homochiral Strategy to Improve Organic Solar Cell Performance

open access: yesAngewandte Chemie, EarlyView.
We develop new bifacial chiral non‐fullerene acceptors (NFAs) for organic solar cells (OSCs). Through comparative investigations of four NFAs including meso, racemic, and chiral entries, we demonstrate the superiority of homochiral NFAs for the first time.
Shuang Li   +4 more
wiley   +2 more sources

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