Results 31 to 40 of about 20,087 (300)
PharmaceuticalsBackground: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Tatiana V. Zinevich +7 more
doaj +1 more source
Chelation and Stereodynamic Equilibria in Neutral Hypercoordinate Organosilicon Complexes of 1-Hydroxy-2-pyridinone [PDF]
, 2013 A series of neutral organosilicon compounds, R3Si(OPO) [R = Me (1), Et (2), Ph (3)], cis-R2Si(OPO)2 [R = Me (4), Et (5), iPr (6), tBu (7), Ph (9)], (CH2)3Si(OPO)2 (8), and cis-R2Si(OPO)Cl [R = Me (10), Et (11)] (OPO = 1-oxo-2-pyridinone) have been ...
Brennessel, William W, Kraft, Bradley M
core +2 more sources
Angewandte Chemie, EarlyView.A streamlined platform for glycosite‐specific antibody conjugation is enabled by LacNAc‐derived cyclic acetal donors, which can be prepared in only two steps and used directly in single‐enzyme Endo S2‐mediated transglycosylation. The platform supports the broad construction of homogeneous gsADCs and gsDACs, with donor 7 producing glycoengineered ...
Deqin Cai +13 more
wiley +2 more sources
Proceedings, 2020 The crystal structures of 4-(3,4-dimethoxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quinazolin-10-one (1) and 4-(3,4-methylene-dioxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quina-zolin-10-one ...
Akmaljon Tojiboev +7 more
doaj +1 more source
Inside the isomers: the tale of chiral switches [PDF]
, 2004 Reproduced with permission from Australian Prescriber The document attached has been archived with permission from the publisher/copyright holder.Chiral drugs are made up of molecules with the same chemical structure, but different three-dimensional ...
Bochner, F., Foster, D., Somogyi, A.
core +1 more source
Angewandte Chemie, EarlyView.Marine polyhydroxylated macrolides’ drug discovery potential is limited by structural complexity and scarce material supply, hindering structure assignment, synthesis, and biological studies. Here, we present an integrated workflow that combines chemogenomic profiling, ultra‐high‐resolution NMR‐guided structural revision and stereochemical assignment ...
Malcolm R. P. George +9 more
wiley +2 more sources
Suggesting a Way to Understand the Actual Potential of Anti-Alzheimer's Disease Drugs That Show Promise in Transgenic Mouse Models. [PDF]
, 2017 One conundrum in Alzheimer's disease (AD) research using transgenic mouse models is the high amount of successful memory-enhancing drugs. By contrast, very few drugs and of limited efficacy are available for humans having this pathology.
Franco Fernández, Rafael +1 more
core +1 more source
Stereodivergent Synthesis of Three Contiguous Stereogenic Centers by Cu/Ir‐Catalyzed Borylallylation
Angewandte Chemie, EarlyView.An alkene borylallylation strategy enabled by cooperative Cu/Ir‐catalysis has been uncovered for accessing three contiguous stereogenic centres. This strategy is notable given the inherent challenges of constructing molecules with multiple stereocenters while maintaining high selectivity bearing diverse functional groups.
Suman Das +2 more
wiley +2 more sources
EFSA Journal, 2011 The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 61 flavouring substances in the Flavouring Group Evaluation 10, Revision 2, using the Procedure in Commission ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj +1 more source
Redox Biology, 2023 Five out of eight human glutathione peroxidases (GPXs) are selenoproteins, representing proteins that contain selenium as part of the amino acid selenocysteine. The GPXs are important for reducing hydroperoxides in a glutathione-consuming manner and thus
Maria Schwarz +7 more
doaj +1 more source