Results 11 to 20 of about 14,256 (222)

Analysis of chiral non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac binding with HSA

Journal of Pharmaceutical Analysis, 2011
The protein binding of non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac with human serum albumin (HSA) was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques. S-(–)-
Chang-Chuan Guo, Yi-Hong Tang, Hai-Hong Hu, Lu-Shan Yu, Hui-Di Jiang, Su Zeng   +5 more
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Stereoselectivity of Interaction of Nonsteroidal Anti-Inflammatory Drug S-Ketoprofen with L/D-Tryptophan in Phospholipid Membranes

Membranes, 2022
The mechanisms of stereoselectivity of the interaction of chiral drugs with active sites of enzymes and cell receptors attract significant attention.
Anna V. Mastova, Olga Yu. Selyutina, Nikolay E. Polyakov   +2 more
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The Synthesis of α-Aminophosphonates via Enantioselective Organocatalytic Reaction of 1-(N-Acylamino)alkylphosphonium Salts with Dimethyl Phosphite

Molecules, 2020
α-Aminophosphonic acids are phosphorus analogues of α-amino acids. Compounds of this type find numerous applications in medicine and crop protection due to their unique biological activities.
Alicja Walęcka-Kurczyk, Krzysztof Walczak, Anna Kuźnik, Sebastian Stecko, Agnieszka Październiok-Holewa   +4 more
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Significance and challenges of stereoselectivity assessing methods in drug metabolism

Journal of Pharmaceutical Analysis, 2016
Stereoselectivity in drug metabolism can not only influence the pharmacological activities, tolerability, safety, and bioavailability of drugs directly, but also cause different kinds of drug–drug interactions.
Zhuowei Shen, Chuang Lv, Su Zeng
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Functional Characterization and Structural Insights Into Stereoselectivity of Pulegone Reductase in Menthol Biosynthesis

Frontiers in Plant Science, 2021
Monoterpenoids are the main components of plant essential oils and the active components of some traditional Chinese medicinal herbs like Mentha haplocalyx Briq., Nepeta tenuifolia Briq., Perilla frutescens (L.) Britt and Pogostemin cablin (Blanco) Benth.
Chanchan Liu, Chanchan Liu, Qiyu Gao, Zhuo Shang, Jian Liu, Siwei Zhou, Jingjie Dang, Licheng Liu, Iris Lange, Narayanan Srividya, B. Markus Lange, Qinan Wu, Qinan Wu, Wei Lin, Wei Lin, Wei Lin, Wei Lin   +16 more
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Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Frontiers in Bioengineering and Biotechnology, 2019
Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are ...
Michele Crotti, Fabio Parmeggiani, Erica Elisa Ferrandi, Francesco G. Gatti, Alessandro Sacchetti, Sergio Riva, Elisabetta Brenna, Daniela Monti   +7 more
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Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine

Journal of Chemistry, 2017
Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice.
Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan   +2 more
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Photothermal conversion triggered thermal asymmetric catalysis within metal nanoparticles loaded homochiral covalent organic framework

Nature Communications, 2019
Achieving both high stereoselectivity and yield is a challenge for conventional asymmetric catalysis. Here, the authors report two metal nanoparticle-loaded and porphyrin-containing homochiral covalent organic framework-based composite catalysts that ...
Hui-Chao Ma, Chen-Chen Zhao, Gong-Jun Chen, Yu-Bin Dong   +3 more
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Synthesis and 1,3-Dipolar Cycloaddition Reactions of Chiral Maleimides

Molecules, 1997
New routes to the synthesis of various novel chiral maleimides are described. The oxabicyclic anhydride 2 readily available exo-Diels-Alder adduct of furan and maleic anhydride was used as a vehicle, which in turn reacted with hydrochlorides of amino ...
Lubor Fisera, Vladimir Ondrus
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Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1

Pharmaceutical Fronts, 2020
This review article summarizes recent developments and innovations in China's pharmaceutical process chemistry over the last several decades. Case studies of dozens of blockbuster drug processes are presented, including bulk drugs, such as the over-the ...
Pei Tang, Biao Nie, Jiuzhong Huang, Yingjun Zhang, Ji Zhang, Fen-er Chen   +5 more
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