Results 41 to 50 of about 14,256 (222)
Protecting Groups in Carbohydrate Chemistry: Influence on Stereoselectivity of Glycosylations
Molecules, 2010 Saccharides are polyhydroxy compounds, and their synthesis requires complex protecting group manipulations. Protecting groups are usually used to temporarily mask a functional group which may interfere with a certain reaction, but protecting groups in ...
Jian Guo, Xin-Shan Ye
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Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria
Molecules, 2020 N-anilinoethylamides are a class of melatoninergic agents with the aniline portion mimicking the indole ring of the natural ligand and the ethylamide chain reproducing that of melatonin.
Gian Marco Elisi +9 more
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Advanced Science, EarlyView.A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang +9 more
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Angewandte Chemie, EarlyView.Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada +5 more
wiley +2 more sources
Advanced Science, EarlyView.ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter +10 more
wiley +1 more source
ProceedingsThis study proposes a two-step process to design a chiral sensor combining MIP (molecularly imprinted polymer) and electrospinning technologies. First, stereoselective S(-)-limonene molecularly imprinted polymer nanoparticles (MINPs) were fabricated and ...
Fabricio N. Molinari +2 more
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Electrophilic Selenium Catalysis with Electrophilic N-F Reagents as the Oxidants
Molecules, 2017 A suitable oxidative system is crucial to electrophilic selenium catalysis (ESC). This short review offers the overview of recent development in ESC with electrophilic N-F reagents as the oxidants. Several highly selective transformations of alkenes such
Ruizhi Guo, Lihao Liao, Xiaodan Zhao
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Recent Advances in the Stereoselective Total Synthesis of Natural Pyranones Having Long Side Chains
Molecules, 2020 Pyranone natural products have attracted great attention in recent years from chemists and biologists due to their fascinating stereoisomeric structural features and impressive bioactivities.
Satya Kumar Avula +4 more
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Advanced Science, EarlyView.Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu +9 more
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Frontiers in Pharmacology, 2020 Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the
Dohyun Kim +7 more
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