Results 71 to 80 of about 166,370 (359)

Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria

Molecules, 2020
N-anilinoethylamides are a class of melatoninergic agents with the aniline portion mimicking the indole ring of the natural ligand and the ethylamide chain reproducing that of melatonin.
Gian Marco Elisi, Annalida Bedini, Laura Scalvini, Caterina Carmi, Silvia Bartolucci, Valeria Lucini, Francesco Scaglione, Marco Mor, Silvia Rivara, Gilberto Spadoni   +9 more
doaj   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Angewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Alejandro Storper, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang   +8 more
wiley   +2 more sources

Housing Molecularly Imprinted Polymer Nanoparticles in Polyvinylpyrrolidone/Multiwall Carbon Nanotube Nanofibers to Detect Chiral Terpene Vapors

Proceedings
This study proposes a two-step process to design a chiral sensor combining MIP (molecularly imprinted polymer) and electrospinning technologies. First, stereoselective S(-)-limonene molecularly imprinted polymer nanoparticles (MINPs) were fabricated and ...
Fabricio N. Molinari, Fabrizio De Cesare, Antonella Macagnano   +2 more
doaj   +1 more source

Synthesis of stereodefined 1-aryl(heteroaryl) substituted 1,2-bis(2-bromopyridin-3-yl)ethenes by selective tandem Suzuki-Miyaura Cross-coupling reactions [PDF]

, 2008
In this communication we show the preparation of stereodefined trisubstituted alkenes 2 can be achieved by sequential selective Suzuki-Miyaura reactions of 2-bromo-3-(2,2-dibromovinyl)pyridines.
Baldino, Salvatore, Chelucci, Giorgio Adolfo   +1 more
core   +1 more source

Recent Advances in Mediator and Proton Relay Usage in Molecular Catalysis

Advanced Science, EarlyView.
The use of electron–proton transfer mediators, redox mediators, and proton relays in synergy with molecular catalysts in energy‐related small‐molecule and organic transformations is discussed, with a focus on recent advances. Linear free‐energy relationship and catalytic Tafel plots provide a systematic foundation for benchmarking these catalytic ...
Yu‐Lin Chi, Wei‐Shuo Chuang, Jing‐Ke Lin, Yu‐Heng Wang   +3 more
wiley   +1 more source

Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos

Angewandte Chemie, EarlyView.
We report a new chiral phosphine ligand, sRuPhos, which permits the highly enantioselective Suzuki–Miyaura coupling of ortho‐aniline and ortho‐phenol building blocks. This results in 2‐amino‐2′‐hydroxybiphenyls with very high enantiomeric excesses, products that will have application in pharmaceutical synthesis and ligand design for catalysis ...
Hamzah Sharif, Luke A. McCall, Matthew G. Sanders, Robert J. Phipps   +3 more
wiley   +2 more sources

Electrophilic Selenium Catalysis with Electrophilic N-F Reagents as the Oxidants

Molecules, 2017
A suitable oxidative system is crucial to electrophilic selenium catalysis (ESC). This short review offers the overview of recent development in ESC with electrophilic N-F reagents as the oxidants. Several highly selective transformations of alkenes such
Ruizhi Guo, Lihao Liao, Xiaodan Zhao
doaj   +1 more source

Recent Advances in the Stereoselective Total Synthesis of Natural Pyranones Having Long Side Chains

Molecules, 2020
Pyranone natural products have attracted great attention in recent years from chemists and biologists due to their fascinating stereoisomeric structural features and impressive bioactivities.
Satya Kumar Avula, Biswanath Das, Rene Csuk, Ahmed Al-Rawahi, Ahmed Al-Harrasi   +4 more
doaj   +1 more source

Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes.

Inorganic Chemistry, 2018
Engineered P450s can catalyze some non-natural reactions with high efficiency and excellent selectivity, such as the carbine transfer, nitrene transfer, C-H insertion, and C-H amination, opening alternative routes for sustainable production of chemicals.
Hao Su, Guangcai Ma, Yongjun Liu
semanticscholar   +1 more source