Results 91 to 100 of about 31,588 (256)

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, Volume 22, Issue 26, 8 May 2026.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

SENYAWA STEROID DARI AKAR TUMBUHAN ASAM KANDIS (Garcinia Cowa) SEBAGAI OBAT PENURUN DEMAM

Jurnal Penelitian Hasil Hutan (Journal of Forest Products Research), 2019
Garcinia cowa termasuk famili Guttiferae, yang dikenal di Indonesia dengan nama asam kandis. Secara tradisional kulit batang Garcinia cowa telah digunakan sebagai antipiretik dan antimikroba, sementara buah dan daunnya untuk memperlancar peredaran darah,
Darwati Darwati, Nurlelasari Nurlelasari, Tri Mayanti, Tri Mayanti   +3 more
doaj   +1 more source

A Network Pharmacology and Experimental Validation Strategy for Hypoglycemic Study of Lonicerae Japonicae Flos on Diabetes

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT As diabetes has become an important public health issue, Lonicerae Japonicae Flos (LJF) had gradually attracted increasing attention on diabetes. This study aimed to investigate the hypoglycemic ingredients and underlying mechanisms of LJF in diabetes using an integrated strategy of network pharmacology, molecular docking and experimental ...
Zhang Nan, Liu Xiaolong, Li Chunyan, Ren Lu, Guo Chao, Xue Jintao   +5 more
wiley   +1 more source

Stigmasterol mitigates estrogen-deficiency-induced osteoporosis through inhibition of phosphorylated p65 and MAPK signaling pathways

Frontiers in Pharmacology
BackgroundOsteoporosis is a pervasive bone metabolic disorder characterized by the progressive degeneration of bone microstructure. Osteoclasts are playing a pivotal role in bone remodeling and resorption.
Qiangqiang Zhao, Qiangqiang Zhao, Xingling Chen, Xingling Chen, Bin Mai, Bin Mai, Feihong Che, Feihong Che, Zhen Zhang, Zhen Zhang, Pan Kang, Pan Kang, Chengyu Hou, Chengyu Hou, Lu Lu, Lu Lu, Liangliang Xu, Liangliang Xu   +17 more
doaj   +1 more source

Gene Silencing and Over-Expression Studies in Concurrence With Promoter Specific Elicitations Reveal the Central Role of WsCYP85A69 in Biosynthesis of Triterpenoids in Withania somnifera (L.) Dunal

Frontiers in Plant Science, 2019
Withania somnifera (Ashwagandha) synthesizes a wide spectrum of triterpenoids that are produced via an intricate isoprenoid pathway whose biosynthetic and regulatory mechanism remains elusive.
Arti Sharma, Gulzar A. Rather, Prashant Misra, Manoj K. Dhar, Surrinder K. Lattoo   +4 more
doaj   +1 more source

Safety of oil from Schizochytrium sp. A2 for use in infant and follow‐on formula as a novel food pursuant to regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an oil derived from the microalga‐like organism Schizochytrium sp. A2 as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Thomas Frenzel, Margarita Aguilera‐Gómez, Francesca Marcon, Monika Neuhäuser‐Berthold, Irene Nuin Garciarena, Emanuela Turla, Areti Favata, Karen Ildico Hirsch‐Ernst   +22 more
wiley   +1 more source

Chromosomal location of a gene that controls sterol esterification in Triticum aestivum L. [PDF]

, 1974
A previously described D genome locus (Pln) that controls sterol esterification in the wheat kernel has been assigned to the short arm of chromosome 7 D by comparison of the steryl ester phenotype of euploid kernels of Triticum aestivum variety Chinese ...
Bennett, Bondjers, Bush, Carbonero, Dupéron, Dupéron, F. Garcia-Olmedo, García-Faure, García-Olmedo, García-Olmedo, Gilles, Grunwald, Grunwald, Hartman, J.V. Torres, Kemp, Méance, Skarsaune   +17 more
core   +2 more sources

Alternative Approaches and Plant‐Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Due to limited access to, and the high cost of conventional veterinary services, Batswana communities often rely on ethnoveterinary practices for livestock health management. This review provides an in‐depth analysis on the ethnoveterinary uses, biological properties and safety assessment of plants utilised in livestock husbandry. A systematic
Tswelelopele G. Mpolokeng, Ndzalama Shikwambana, Mompati V. Chakale, John A. Asong, Lyndy J. McGaw, Stephen O. Amoo, Nqobile A. Masondo, Adeyemi O. Aremu   +7 more
wiley   +1 more source

Chemical Constituents from Macaranga lowii King ex Hook.f. (Euphorbiaceae) and Their Effects on Antioxidant Activity

ASM Science Journal, 2023
The genus Macaranga comprises about 300 species worldwide and is commonly distributed in the tropical region of Africa, Southeast Asia, China and India.
AISYAH SALIHAH KAMAROZAMAN
doaj   +1 more source

Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis

Open Life Sciences
Intervertebral disc degeneration (IVDD) is a core factor in spinal degeneration. To date, there is no effective treatment for IVDD. It is urgent to identify the pathogenesis of IVDD to develop effective strategies for IVDD treatment. Alleviating endplate
Li Hao, Chen Xiaofeng, Huang Baoci, He Junjie, Xie Junxian, Guo Weijun, Liang Jinjun, Ruan Jiajian, Liu Jincheng, Xiang Zhen, Zhu Lixin   +10 more
doaj   +1 more source