Electronegative low‐density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade [PDF]
Journal of Diabetes Investigation, 2020 Aims/Introduction Electronegative low‐density lipoprotein (L5) is the most atherogenic fraction of low‐density lipoprotein and is elevated in people with metabolic syndrome (MetS), whereas the retinol‐binding protein 4 receptor (stimulated by retinoic ...
Chao‐Hung Chen +9 more
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Role of stimulated by retinoic acid 6 in 46 children of coarctation of the aorta [PDF]
Heliyon(1) ObjectiveCoarctation of the aorta (CoA) is a complex congenital heart disease. Research on differential genes in patients with CoA and other groups of aortas and investigating the pathogenesis of aorta coarctation is essential for prevention and ...
Xin Jin +5 more
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All-Trans Retinoic Acid Attenuates Inflammation and Insulin Resistance Induced by Adipocyte–Macrophage Coculture [PDF]
MoleculesObesity is characterized by chronic low-grade inflammation, largely driven by macrophage infiltration into adipose tissue, which contributes to the development of insulin resistance.
Kwang-Rim Baek, Hye-Kyeong Kim
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All-trans retinoic acid prevents oxidative stress-mediated cellular senescence via upregulation of insulin-like growth factor binding protein-6 in normal human epidermal keratinocytes [PDF]
Archives of Biological Sciences, 2021 All-trans retinoic acid (ATRA) influences cellular proliferation and differentiation but its mechanisms of action are not understood in keratinocytes. To investigate the potential mechanisms of action of ATRA in keratinocytes, microarray analysis of ATRA-
Choi Hyangtae +6 more
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Genetic dissection in mice reveals a dynamic crosstalk between the delivery pathways of vitamin A
Journal of Lipid Research, 2022 Vitamin A is distributed within the body to support chromophore synthesis in the eyes and retinoid signaling in most other tissues. Two pathways exist for the delivery of vitamin A: the extrinsic pathway transports dietary vitamin A in lipoproteins from ...
Jean Moon +2 more
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Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis
Cell & Bioscience, 2021 Background Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis.
Injoo Hwang +4 more
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Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. [PDF]
PLoS ONE, 2016 After lesions to the mammalian optic nerve, the great majority of retinal ganglion cells (RGCs) die before their axons have even had a chance to regenerate.
Mildred V Duprey-Díaz +2 more
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Journal of Venomous Animals and Toxins including Tropical Diseases, 2023 Background: Propolis exhibits huge potential in the pharmaceutical industry. In the present study, its effects were investigated on dendritic cells (DCs) stimulated with a tumor antigen (MAGE-1) and retinoic acid (RA) and on T lymphocytes to observe a ...
Karina Basso Santiago +8 more
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Frontiers in Oncology, 2020 Retinol plays a significant role in several physiological processes through their nuclear receptors, whose expression depends on retinol cytoplasmic concentration.
Saé Muñiz-Hernández +9 more
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Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A. [PDF]
PLoS ONE, 2014 Morbidity and mortality due to viral infections are major health concerns, particularly when individuals are vitamin A deficient. Vitamin A deficiency significantly impairs mucosal IgA, a first line of defense against virus at its point of entry ...
Rajeev Rudraraju +5 more
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