Results 11 to 20 of about 409,058 (151)

Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies [PDF]

Scientific Reports, 2019
AbstractAnti-mucin1 (MUC1) antibodies have long been used clinically in cancer diagnosis and therapy and specific bindings of some of them are known to be dependent on the differential glycosylation of MUC1. However, a systematic comparison of the binding specificities of anti-MUC1 antibodies was not previously conducted.
Yayoi Yoshimura, Kaori Denda-Nagai, Yoshie Takahashi, Izuru Nagashima, Hiroki Shimizu, Toshimitsu Kishimoto, Miki Noji, Shigeyuki Shichino, Yasunori Chiba, Tatsuro Irimura   +9 more
openaire   +3 more sources

Using Synthetic Glycans to Investigate Anti-Glycan Antibodies and Explore Their Medical Potential. [PDF]

Angew Chem Int Ed Engl
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Weber F, Valenti A, Ledvinka J, Moscovitz O, Seeberger PH.   +4 more
europepmc   +2 more sources

Comprehensive Profiling Reveals Sialyl-Tn Upregulation and Prognostic Value in Prostate Cancer. [PDF]

Pathol Int
This study utilises a novel antibody (L2A5) to comprehensively monitor sialyl‐Tn antigen (sTn) expression levels in clinical prostate cancer tissues. We reveal sTn is expressed in 44% of prostate tumours and find prostate cancer patients with high sTn levels have significantly poorer survival times.
Hodgson K, Blencoe L, Smith E, Sasikumar A, Peng Z, Orozco-Moreno M, Beatson R, Videira PA, Munkley J.   +8 more
europepmc   +2 more sources

The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer [PDF]

Oncotarget, 2015
Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal metastatic castration-resistant disease. Here we used RNA-Seq coupled with bioinformatic analyses of androgen-receptor (AR) binding sites
Munkley, Jennifer, Oltean, Sebastian, Vodák, Daniel, Wilson, Brian T., Livermore, Karen E., Zhou, Yan, Star, Eleanor, Floros, Vasileios I., Johannessen, Bjarne, Knight, Bridget, McCullagh, Paul, McGrath, John, Crundwell, Malcolm, Skotheim, Rolf I., Robson, Craig N., Leung, Hing Y., Harries, Lorna W., Rajan, Prabhakar, Mills, Ian G., Elliott, David J.   +19 more
openaire   +7 more sources

Sialyl-Tn expression correlates with reduced c-Myc and immune modulation in triple negative breast cancer [PDF]

Scientific Reports
Triple negative breast cancer (TNBC) is an aggressive, heterogeneous cancer with lack of targeted therapies. The cancer-associated sialyl-Tn (STn) antigen has a significant role in cancer, yet its involvement in TNBC remains unexplored.
Rita Adubeiro Lourenço, Daniela Ferreira Barreira, Carla Lopes, Pedro Granjo, Ana Sofia Rodrigues, Zélia Silva, Manuela Martins, Ana Rita Grosso, Paula A. Videira   +8 more
doaj   +2 more sources

Phage Display Reveals VLRB-Mediated Recognition of Minimal Tumor Glycan Antigen Sialyl-Tn [PDF]

Current Issues in Molecular Biology
Sialyl-Tn (sTn) is a tumor-associated carbohydrate antigen (TACA) abundantly expressed by various types of carcinomas. While conventional antibody-based platforms have traditionally been used for the detection and targeting of sTn, alternative binding ...
Mark Rickard N. Angelia, Abigail Joy D. Rodelas-Angelia, Youngrim Kim, Cheolung Yang, Hyeok Jang, Seungpyo Jeong, Jihyun Mun, Kim D. Thompson, Taesung Jung   +8 more
doaj   +2 more sources

Pan-carcinoma sialyl-Tn-targeting expands CAR therapy to solid tumors [PDF]

Cell Reports Medicine
Summary: Accurate identification of tumor-specific markers is vital for developing chimeric antigen receptor (CAR)-based therapies. While cell surface antigens are seldom cancer-restricted, their post-translational modifications (PTMs), particularly ...
Rafaela Abrantes, Christopher Forcados, David J. Warren, Liliana Santos-Ferreira, Karianne Giller Fleten, Emanuel Senra, Ana Filipa Costa, Klara Krpina, Rui Henrique, Ann Magritt Liberg, Puneet Rawat, Pascal Gelebart, Emmet McCormack, Line Bjørge, Ben Davidson, Victor Greiff, Daniela Elena Costea, Filipe Pinto, Kjersti Flatmark, Catarina Gomes, Else Marit Inderberg, Celso A. Reis, Sébastien Wälchli   +22 more
doaj   +2 more sources

Predictive ability of novel glycovariant biomarkers of CA125 and CA15-3 up to three years prior to ovarian cancer diagnosis: a population-based case-control study [PDF]

Journal of Ovarian Research
Background Nanoparticle immunoassays for CA125 and CA15-3 glycovariants are promising tools for epithelial ovarian cancer (EOC) and borderline ovarian tumor (BOT) early detection. Method This retrospective population-based study utilized prospective (
Hanna Roos Alexander, Shamima Afrin Ruma, Shruti Jain, Eva Lundin, Per Liv, Pernilla Israelsson, Kim Pettersson, Annika Idahl   +7 more
doaj   +2 more sources

An in vitro approach for simulating divergent Golgi O-glycosylation of tumor-associated MUC1 from normal MUC1 [PDF]

Nature Communications
Peptide O-glycosylation relies on the coordinated action of glycosyltransferases across the endoplasmic reticulum (ER) and Golgi apparatus. However, the molecular mechanisms driving aberrant glycosylation in cancer remain poorly understood.
Abdullateef Nashed, Kyllen Dilsook, Tharindu Senapathi, Kevin J. Naidoo   +3 more
doaj   +2 more sources

Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component [PDF]

, 1996
The Ki-67 antigen is detected in proliferating cells in all phases of the cell division cycle. Throughout most of interphase, the Ki-67 antigen is localised within the nucleolus.
Kill, IR
core   +6 more sources