Results 31 to 40 of about 409,058 (151)

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

BMC Cancer, 2018
Background The Tn neoantigen (GalNAcα1-O-Ser/Thr) is an O-glycan expressed in various types of human cancers. Studies in several Tn-expressing cancer cell lines and pancreatic tumors have identified loss of Cosmc expression caused by either mutations or ...
Xiaodong Sun, Tongzhong Ju, Richard D. Cummings   +2 more
doaj   +1 more source

Synthetic and Immunological Studies of 5′-N-Phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins [PDF]

Bioconjugate Chemistry, 2008
5'- N-Phenylacetyl sTn (sTnNPhAc), an unnatural derivative of sTn antigen expressed by many tumors, and its alpha-linked protein conjugates were prepared and investigated to explore glycoconjugate cancer vaccines. sTnNPhAcalpha-KLH elicited a robust T cell dependent immunity. The antiserum derived from sTnNPhAcalpha- or sTnNPhAcbeta-KLH-inoculated mice
Qianli, Wang, Sandamali Amarasingha, Ekanayaka, Jian, Wu, Junping, Zhang, Zhongwu, Guo   +4 more
openaire   +2 more sources

Human LFP recordings from STN during sequential conflict task

, 2020
Dataset available for downlaod from: https://data.mrc.ox.ac.uk/data-set/human-lfp-recordings-stn-during-sequential-conflict-task LFP recordings from human subthalamic nucleus, filtered for beta and theta band oscillations, epoched around cue stimulus ...
Oswal, Ashwini, Dayal, Viswas, Pedrosa, David, Bogacz, Rafal, Little, Simon, Litvak, Vladmimir, Herz, Damian, Patai, Eva   +7 more
core   +1 more source

Carcinoembryonic Antigen Gene Family [PDF]

, 1991
The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons.
Zimmermann, Wolfgang, Grunert, Fritz, Thompson, John A.   +2 more
core   +1 more source

Improving the Antigenicity of sTn Antigen by Modification of Its Sialic Acid Residue for Development of Glycoconjugate Cancer Vaccines

, 2016
Sialyl Tn (sTn) antigen is a sialylated disaccharide abundantly expressed by many tumors. To search for effective cancer immunotherapies based on sTn antigen, we designed and synthesized a series of unnatural N-acyl derivatives of sTn and studied their ...
Zhongwu Guo (673969), Jian Wu (41301)
core   +1 more source

Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics.

PLoS ONE, 2015
Muscle invasive bladder cancer (MIBC, stage ≥T2) is generally associated with poor prognosis, constituting the second most common cause of death among genitourinary tumours.
Céu Costa, Sofia Pereira, Luís Lima, Luís Lima, Andreia Peixoto, Elisabete Fernandes, Diogo Neves, Manuel Neves, Cristiana Gaiteiro, Ana Tavares, Rui M Gil da Costa, Ricardo Cruz, Teresina Amaro, Paula A Oliveira, José Alexandre Ferreira, Lúcio L Santos   +15 more
doaj   +1 more source

O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotypeResearch in context

EBioMedicine, 2019
Background: Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer ...
Daniela Freitas, Diana Campos, Joana Gomes, Filipe Pinto, Joana A. Macedo, Rita Matos, Stefan Mereiter, Marta T. Pinto, António Polónia, Fátima Gartner, Ana Magalhães, Celso A. Reis   +11 more
doaj   +1 more source

STN-DBS parameter optimization for speech in PD (Knowles et al., 2018)

, 2018
Purpose: The settings of 3 electrical stimulation parameters were adjusted in 12 speakers with Parkinson’s disease (PD) with deep brain stimulation of the subthalamic nucleus (STN-DBS) to examine their effects on vowel acoustics and speech ...
Greydon Gilmore (4860742), Mandar Jog (2622277), Cynthia Mancinelli (4860739), Thea Knowles (4860745), Scott Adams (4860748), Anita Abeyesekera (4860736)   +5 more
core   +1 more source

Tapeworm testing: Coprological and antibody‐based approaches across colic types in a German equine hospital population

Equine Veterinary Education, EarlyView.
Summary Background The association between tapeworm infection and equine colic is established, but gaps remain regarding specific colic types. Objectives To assess the relationship between tapeworm test results and equine colic types: The study aimed to determine if ileocaecal disorders (IC) are more frequently associated with Anoplocephala spp ...
K. L. Adamasky, K. Drozdzewska, P. Schmitz, N. Peczak, K. L. Lightbody, J. B. Matthews, M. K. Nielsen, R. Merle, G. von Samson‐Himmelstjerna, H. Gehlen   +9 more
wiley   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source