NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections [PDF]
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
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The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers
Frontiers in Oncology, 2023 Cellular signaling pathways are intricately regulated to maintain homeostasis. During cancer progression, these mechanisms are manipulated to become harmful. O-glycosylation, a crucial post-translational modification, is one such pathway that can lead to
Christabelle Rajesh +1 more
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Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate–carbohydrate interactions [PDF]
Glycobiology, 2018 The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn ...
Sletmoen, Marit +4 more
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A Sweet Warning: Mucin-Type O-Glycans in Cancer
Cells, 2022 Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues.
Yuhan Zhang +6 more
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Reciprocal expression of tumour-associated carbohydrate antigens (Tn/sTn) and nuclear factor-B serves as an indicator of the prognosis of oral squamous cell carcinoma [PDF]
Journal for ImmunoTherapy of Cancer, 2013 To determine whether expression of tumour-associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor-B (NF-B), is related to the invasiveness of oral squamous cell carcinoma (OSCC) by correlating these markers with the wellestablished invasive pattern grading score (IPGS) and clinicopathological parameters ...
Lin, Chi-Yu +3 more
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Frontiers in Molecular Biosciences, 2022 Human N-acetylgalactosamine-α2,6-sialyltransferase (hST6GalNAc I) is the major enzyme involved in the biosynthesis of sialyl-Tn antigen (sTn), which is known to be expressed in more than 80% of human carcinomas and correlated with poor prognosis in ...
So-Young An +5 more
doaj +1 more source
, 2016 The abnormal glycans expressed on the surface of tumor cells, known as tumor-associated carbohydrate antigens, increase the chance to develop carbohydrate-based anticancer vaccines.
Yue Wang (65477) +5 more
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Sialyl-Tn in Cancer: (How) Did We Miss the Target?
Biomolecules, 2012 Sialyl-Tn antigen (STn) is a short O-glycan containing a sialic acid residue a2,6-linked to GalNAca-O-Ser/Thr. The biosynthesis of STn is mediated by a specific sialyltransferase termed ST6GalNAc I, which competes with O-glycans elongating ...
Philippe Delannoy +2 more
doaj +1 more source
Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
Journal of Experimental & Clinical Cancer Research, 2020 Background Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target module (TM) which is characterized ...
Liliana R. Loureiro +10 more
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Composição e Expressividade das Despesas com Educação na Execução do Orçamento do Governo Federal do Brasil [PDF]
, 2008 O objetivo deste artigo é identificar e analisar os valores, a composição e a expressividade das despesas empenhadas na função educação do orçamento do Governo Federal do Brasil referentes aos anos de 2006 e 2007, comparando-as às ...
da Cruz, Flávio +4 more
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