Results 41 to 50 of about 409,058 (151)

Avaliação do controle das atividades que auxiliem os processos de prestação de contas de convênios firmados entre a Financiadora de Estudos e Projetos FINEP e a Fundação de Amparo a Pesquisa e Extensão Universitária FAPEU a luz da Instrução Normativa 01/91 [PDF]

open access: yes, 2012
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Ciências ContábeisA infração de qualquer um dos artigos da Instrução Normativa STN nº 01/97, pode implicar dúvidas e questionamentos por parte do órgão financiador ...
Ventura, Georgia Maia
core  

Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma

open access: yesJournal of Hematology & Oncology, 2016
Glycosylation is the most complex post-translational modification of proteins. Altered glycans on the tumor- and host-cell surface and in the tumor microenvironment have been identified to mediate critical events in cancer pathogenesis and progression ...
Wan-Ling Ho   +4 more
doaj   +1 more source

The Carcinoembryonic Antigen Gene Family [PDF]

open access: yes, 1988
The molecular cloning of carcinoembryonic antigen (CEA) and several cross-reacting antigens reveals a basic domain structure for the whole family, which shows structural similarities to the immunoglobulin superfamily.
Zimmermann, Wolfgang, Thompson, John A.
core   +1 more source

Sialyl-Tn glycan epitope as a target for pancreatic cancer therapies

open access: yesFrontiers in Oncology
Pancreatic cancer (PC) is the sixth leading cause of cancer-related deaths worldwide, primarily due to late-stage diagnosis and limited treatment options.
Rafaela Abrantes   +14 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

open access: yesAdvanced Science, Volume 13, Issue 49, 3 September 2026.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong   +14 more
wiley   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

open access: yesAdvanced Science, Volume 13, Issue 52, 18 September 2026.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming   +9 more
wiley   +1 more source

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens

open access: yesCancer Management and Research, 2020
Feng Xu,1,* Dong Wang,2,* JianXiu Cui,1 Jie Li,1 Hongchuan Jiang1 1Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China; 2Department of Oncology, Affiliated Hospital of ...
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Single‐Cell Glycomics of the Pancreatic Tumor Microenvironment: Technologies, Glyco‐Immune Checkpoints, and Tumor–Immune Communication

open access: yesAdvanced Biology, Volume 10, Issue 8, August 2026.
Single‐cell glycomics reveals how epithelial–mesenchymal transition (EMT) remodels the cancer cell glycome and reshapes communication with immune cells. Emerging technologies, including scGR‐seq and GlycoChat, uncover glyco‐immune checkpoints in pancreatic cancer, highlighting glycans as active regulators of tumor–immune interactions and providing a ...
Dinh Xuan Tuan Anh, Hiroaki Tateno
wiley   +1 more source

Decoding the molecular basis of the specificity of an anti-sTn antibody [PDF]

open access: yes
The mucin O-glycan sialyl Tn antigen (sTn, Neu5Acα2-6GalNAcα1-O-Ser/Thr) is an antigen associated with different types of cancers, often linked with a higher risk of metastasis and poor prognosis.
Westerlind, Ulrika,   +66 more
core   +1 more source

STN

open access: yes
STN recording and estim data for eLife-VOR-RA-2024 ...
Long Ding
core   +8 more sources

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