Results 141 to 150 of about 87,981 (309)

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Effects of iontophoresis and electroporation on the stratum corneum. Review of the biophysical studies.

, 1999
This review focuses on the effects induced by iontophoresis and electroporation on the stratum corneum of the skin. Hence, the aims were: (1) to contribute to the understanding of the mechanisms of drug transport by these methods; (2) to evaluate the ...
Joke Bouwstra, Véronique Préat, Bouwstra, Anne Jadoul, Jadoul, Anne, Préat, Véronique   +5 more
core   +1 more source

Advances in deep‐tissue fluorescence imaging through optical clearing: A review

VIEW, EarlyView.
Optical clearing refers to techniques that are used to improve the optical transparency of biological tissues. Optical clearing enables imaging of deeper lying tissues as well as 3D volumetric imaging of whole organs. This review examines reports on the integration of optical clearing with advanced fluorescence imaging techniques, with particular ...
Alaka Pramod, Sanoop Pavithran M, Valery V. Tuchin, Santhosh Chidangil, C. S. Suchand Sandeep   +4 more
wiley   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Sensory Biology of the Franciscana (Pontoporia blainvillei, Pontoporiidae, Cetartiodactyla): Ontogenetic Modifications of Vibrissae and Vibrissal Crypts

Integrative Zoology, EarlyView.
The transition of cetaceans from a terrestrial to an aquatic environment involved a crucial sensory adaptation to environments with limited visibility. Vibrissae, important mechanoreceptors, undergo an ontogenetic transformation in odontocetes. This research describes the histomorphology of vibrissae and crypts at different developmental stages ...
Cecilia Mariana Krmpotic, Cleopatra Mara Loza, Alejo Carlos Scarano, Pedro Fernando Andrés‐Laube, Francisco Acuña, Juan Pablo Loureiro, Carolina Natalia Zanuzzi, Nicolás Nahuel Castro, María Teresa Pombo, Lorenzo von Fersen, Claudio Gustavo Barbeito   +10 more
wiley   +1 more source

Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway

Integrative Zoology, EarlyView.
The schematic diagram illustrates that the amphibian‐derived peptide OA‐AL14 protects against UVB‐induced skin photoaging through a dual mechanism: activating the Nrf2 pathway to counteract oxidative stress and modulating the AMPK/mTOR axis to induce protective autophagy. ABSTRACT Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a
Ying Peng, Yutong Wu, Zhe Fu, Zijian Kang, Qiuye Jia, Wenbi Zhao, Ziyi Wang, Yuexi Liu, Ruijie Zhang, Yuansheng Li, Zeqiong Ru, Wenrou Su, Naixin Liu, Yilin Li, Saige Yin, Ying Wang, Xinwang Yang   +16 more
wiley   +1 more source

Saving Water to Survive: Alternative Water Loss Strategies Could Explain Color Polymorphism Maintenance in a Lacertid Lizard

Integrative Zoology, EarlyView.
We demonstrate that red male Podarcis muralis exhibit higher evaporative water loss compared to other morphs, indicating a physiological strategy that prioritizes hydroregulation over fine thermoregulation. This suggests red morphs are adapted to cooler, wetter niches, while white and yellow morphs possess superior water conservation mechanisms to ...
Roberto Sacchi, Stefano Scali, Thomas Dadda, Federico Storniolo, Marco A. L. Zuffi, Andrea Melotto, Stéphanie Sherpa, Federica Frongia, Danny Tassi, Gentile Francesco Ficetola, Marco Mangiacotti   +10 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of Strauchbufo raddei and Multi‐Omic Insights Into Drought Adaptation

Integrative Zoology, EarlyView.
ABSTRACT Understanding how amphibians adapt to terrestrial and arid environments is important for elucidating vertebrate terrestrialization. In this study, we present the first chromosome‐level, high‐quality genome assembly of Strauchbufo raddei, constructed using PacBio HiFi long‐read sequencing and Hi‐C scaffolding. The assembled genome is 4.47 Gb in
Fanrui Chen, Rui Su, Chengqi Wang, Shengnan Wang, Jinjing Wang, Yuquan Miao, Wenya Zhang, Wei Zhao   +7 more
wiley   +1 more source

Active enhancement methods for intra- and transdermal drug delivery: a review

Zdravniški Vestnik, 2013
Transdermal route has some advantages over other drug administration routes. These include avoidance of first pass effect (hepatic metabolism), better pharmacokinetic profile, reduction of side effects and good patient compliance.
Barbara Zorec, Véronique Préat, Damijan Miklavčič, Nataša Pavšelj   +3 more
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