Results 171 to 180 of about 139,184 (387)

Stratum Corneum Ceramide Abnormalities in Atopic Dermatitis: Pathophysiology and Implications for Disease Management

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT The stratum corneum, as the outermost layer of the skin, functions as a critical barrier that maintains cutaneous hydration and systemic homeostasis. Among its structural lipids, ceramides constitute the most abundant and diverse component. These molecules are essential for the formation of lamellar structures that secure barrier integrity ...
Takashi Sakai
wiley   +1 more source

Safety Evaluation of Fine Bubble Shower Washing for Patients With Atopic Dermatitis: A Double‐Blind, Randomized, Prospective Crossover Clinical Trial

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) involves chronic eczema resulting from barrier dysfunction. Fine bubble (FB) technology generates microbubbles (< 100 μm) and ultrafine bubbles (< 1 μm) for surfactant‐sparing cleansing. We assessed the short‐term safety of an FB shower in AD.
Hiroshi Kato   +9 more
wiley   +1 more source

Bidirectional Associations Between Seborrheic Dermatitis and Epithelial Barrier Diseases: A Retrospective Cohort Study

open access: yesAllergy, EarlyView.
This study explores the bidirectional associations between SD and EBDs in a cohort of 5,083,689 individuals in a US administrative claims database. Positive bidirectional associations were found between SD and many EBDs of the skin, respiratory, gastrointestinal, and ocular surfaces. Our results support the EBT as a shared driver of EBD pathogenesis at
Sabrina Meng   +6 more
wiley   +1 more source

Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation

open access: yesAllergy, EarlyView.
Integrating skin barrier measurements with omics and machine learning, we found that postbiotics and NAM regulate skin homeostasis through distinct, strain‐ and dose‐dependent mechanisms. Postbiotics primarily modulate skin barrier function by promoting keratinocyte differentiation and suppressing inflammation.
Yagiz Pat   +21 more
wiley   +1 more source

Active enhancement methods for intra- and transdermal drug delivery: a review

open access: yesZdravniški Vestnik, 2013
Transdermal route has some advantages over other drug administration routes. These include avoidance of first pass effect (hepatic metabolism), better pharmacokinetic profile, reduction of side effects and good patient compliance.
Barbara Zorec   +3 more
doaj  

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