To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo+3 more
wiley +1 more source
Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20 radioimmunotherapy of B-cell lymphomas [PDF]
John M. Pagel+8 more
openalex +1 more source
Protocol for identifying components of subcellular compartments by antibody-based in situ biotinylation. [PDF]
Suzuki H+6 more
europepmc +1 more source
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu+7 more
wiley +1 more source
CRISPR-CISH: an in situ chromogenic DNA repeat detection system for research and life science education. [PDF]
Potlapalli BP+4 more
europepmc +1 more source
A DNA aptamer (A3) with nanomolar affinity for CAR‐T cells is developed via Cell‐SELEX. In Nalm6 tumor‐bearing mice, Cy5‐labeled A3 enables long‐term fluorescence imaging and tracks the biodistribution of CAR‐T cells, with tumor signal peaking on day 14 after CAR‐T cell administration.
Minghui Chen+8 more
wiley +1 more source
A Direct Streptavidin-Binding Assay Does Not Accurately Quantitate Biotin in Human Urine
Donald M. Mock+2 more
openalex +1 more source
Attachment of Streptavidin to β‐Cyclodextrin Molecular Printboards via Orthogonal Host–Guest and Protein–Ligand Interactions [PDF]
Manon J. W. Ludden+3 more
openalex +1 more source
Insights on using plastic-based dual in-plane nanopore sensors for differentiation and shape determinations of single protein molecules. [PDF]
Shivanka S+8 more
europepmc +1 more source