Results 111 to 120 of about 149 (149)

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Military Service Roles and ALS Among Veterans: A Matched Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT While military service is an established risk factor for amyotrophic lateral sclerosis (ALS), it remains unclear whether this association is linked to combat. We conducted a matched case–control study comparing 191 ALS patients who were veterans of the Israeli Defense Forces (IDF) with known military service type and 1910 matched controls. The
Asaf Honig, Roy Dayan, Amir Knaani, Hagai Levine, Marc Gotkine   +4 more
wiley   +1 more source

Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The disease hallmarks cortical lesion, central vein sign (CVS) and paramagnetic rim lesions identified in MS have not yet been comprehensively investigated in ...
Lei Su, Joseph Kuchling, Chenyang Gao, Thoralf Niendorf, Carsten Finke, Zhe Zhang, Ai Guo, Jing Jing, De‐Cai Tian, Yu‐Jing Li, Mengting Zhang, Xiaoyu Shi, Xinyao Liu, Huabing Wang, Yaou Liu, Claudia Chien, Michael Levy, Yunyun Duan, Friedemann Paul, Fu‐Dong Shi   +19 more
wiley   +1 more source

Pathway Analyses of Inherited Neuropathies Identify Putative Common Mechanisms of Axon Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Inherited neuropathies (IN) are associated with over 100 different genetic mutations presenting with a variety of phenotypes. This complexity suggests multiple pathways may converge onto a limited number of downstream pathways to effect axonal injury.
Christopher R. Cashman, Craig Blackstone, Reza Sadjadi   +2 more
wiley   +1 more source

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Mechanisms of memory under stress

Neuron, 2022
It is well established that stress has a major impact on memory, driven by the concerted action of various stress mediators on the brain. Recent years, however, have seen considerable advances in our understanding of the cellular, neural network, and cognitive mechanisms through which stress alters memory.
Schwabe, Lars, Hermans, Erno J., Joëls, Marian, Roozendaal, Benno   +3 more
openaire   +2 more sources

The mechanisms of stress and immunosuppression

Medical Hypotheses, 1981
The effects of stress on the central nervous system, endocrine balance and immunity were observed in male Sprague-Dawley rats. Food and water were supplied in unlimited quantities. Extraneous odors were kept away from the control room by an exhaust fan in the adjacent room. At 70 days, experimentation occured for 20 days.
M. Keeling, J. Richardson
openaire   +3 more sources

Stress — mechanisms of immunosuppression

Veterinary Immunology and Immunopathology, 1991
Stress, a term commonly used to describe varied phenomena, should be restricted to describe an adaptive response by an animal to threats to homeostasis. The threats to homeostasis are called stressors. Stressors include a variety of physical, psychological, chemical, or infectious causes that are modified by intrinsic and extrinsic factors. Examples of
John E. Dohms, Alan Metz
openaire   +3 more sources

Rethink Stress Mechanisms

2022
This study has two primary objectives: 1. Compare the durability of two different stress mindset interventions: (a) A meta-cognitive stress mindset intervention that explains that stress can be both positive and negative and that the way people view stress can, in part, determine whether they experience positive or negative effects from it (b) The ...
Handley-Miner, Isaac, Santoro, Erik, Smith, Eric, Crum, Alia   +3 more
openaire   +1 more source

On Stress and Coping Mechanisms

Issues in Mental Health Nursing, 1985
(1985). On Stress and Coping Mechanisms. Issues in Mental Health Nursing: Vol. 7, No. 1-4, pp. 3-24.
Hans Selye, Jean Tachè
openaire   +2 more sources