Results 41 to 50 of about 450,357 (249)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Sarcomere Mechanics in the Stress Fiber [PDF]

Biophysical Journal, 2009
Actin filaments inside endothelial cells assemble into tensed bundles called stress fibers. Stress fibers are observed in vivo in a variety of tissues including the aorta, the heart, the spleen, the eye, and hair follicles. Sarcomeres are the force generating units of stress fibers and are responsible for generating intracellular tension.
Tanmay P. Lele, Robert J. Russell, Richard B. Dickinson   +2 more
openaire   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Mechanisms of Cellular Stress Adaptation

, 2020
Cells need to continuously adapt to changes in their environment, such as a rise in temperature. Heat causes proteins to unfold, thereby compromising intracellular processes and structures. To brace against this menace, organisms have evolved a highly conserved protective programme, the so-called heat shock response (HSR).
openaire   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Proline Mechanisms of Stress Survival [PDF]

Antioxidants & Redox Signaling, 2013
The imino acid proline is utilized by different organisms to offset cellular imbalances caused by environmental stress. The wide use in nature of proline as a stress adaptor molecule indicates that proline has a fundamental biological role in stress response.
Liang, Xinwen, Zhang, Lu, Natarajan, Sathish Kumar, Becker, Donald F.   +3 more
openaire   +3 more sources

Stress and Strain State Analysis of Crack Front in Dissimilar Metal Welded Joints with Dual Field of Mechanical Heterogeneity and Residual Stress

Science and Technology of Nuclear Installations, 2022
The micro-mechanical state at the crack front is one of the key factors affecting the stress corrosion cracking (SCC) growth behavior. The mechanical heterogeneity and residual stress in the dissimilar metal welded joint (DMWJ) induce the micro ...
Shun Zhang, He Xue, Yubiao Zhang, Kuan Zhao, Jiaqing Zhang   +4 more
doaj   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source