Stress Erythropoiesis is a Key Inflammatory Response [PDF]
Cells, 2020 Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen.
Robert F. Paulson +3 more
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Targeting Stress Erythropoiesis Pathways in Cancer [PDF]
Frontiers in Physiology, 2022 Cancer-related anemia (CRA) is a common multifactorial disorder that adversely affects the quality of life and overall prognosis in patients with cancer.
Sanja Vignjević Petrinović +4 more
doaj +9 more sources
Microenvironmental dynamics in steady-state and stress erythropoiesis [PDF]
Blood ScienceAnemia is a condition marked by a shortage of red blood cells or hemoglobin, resulting in a diminished ability of the blood to carry oxygen. In response to anemia or hypoxia, the body activates a compensatory mechanism known as stress erythropoiesis ...
Chong Yang, Toshio Suda
doaj +5 more sources
Editorial: Stress erythropoiesis [PDF]
Frontiers in Physiology, 2023 Jaira Ferreira de Vasconcellos +2 more
doaj +6 more sources
Heme oxygenase-1 deletion affects stress erythropoiesis. [PDF]
PLoS ONE, 2011 BACKGROUND:Homeostatic erythropoiesis leads to the formation of mature red blood cells under non-stress conditions, and the production of new erythrocytes occurs as the need arises.
Yu-An Cao +5 more
doaj +7 more sources
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche [PDF]
Blood Advances, 2019 : Anemic stress induces the proliferation of stress erythroid progenitors in the murine spleen that subsequently differentiate to generate erythrocytes to maintain homeostasis.
Siyang Hao +8 more
doaj +5 more sources
Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms [PDF]
Frontiers in Physiology, 2023 Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen.
Baiye Ruan +2 more
doaj +4 more sources
Functional requirements for a Samd14-capping protein complex in stress erythropoiesis [PDF]
eLife, 2022 Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals—involving cooperation between stem cell factor (SCF)/Kit signaling and other signaling inputs—are required for the ...
Suhita Ray +7 more
doaj +5 more sources
Stress erythropoiesis: definitions and models for its study [PDF]
Experimental Hematology, 2020 Steady-state erythropoiesis generates new erythrocytes at a constant rate, and it has enormous productive capacity. This production is balanced by the removal of senescent erythrocytes by macrophages in the spleen and liver. Erythroid homeostasis is highly regulated to maintain sufficient erythrocytes for efficient oxygen delivery to the tissues, while
Robert Paulson, Jane A Little
exaly +5 more sources
Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis [PDF]
Blood, 2018 Key Points Selenoproteins, and in particular SelenoW, are required for stress erythroid progenitor proliferation and maturation. Macrophages require selenoproteins to maintain erythropoietic niche competency.
Robert Paulson, Ross Hardison
exaly +4 more sources