Angiotensin signaling is essential for stress erythropoiesis but causes retention of dysfunctional mitochondria in RBCs [PDF]
JCI InsightWe previously reported that excessive angiotensin-II→AT receptor-1 (AT→ATR1) signaling results in sickle cell anemia–associated (SCA-associated) nephropathy.
Parul Rai +8 more
doaj +2 more sources
Rats provide a superior model of human stress erythropoiesis. [PDF]
Exp Hematol, 2019 Mouse models are widely used to study human erythropoiesis in vivo. One important caveat using mouse models is that mice often develop significant extramedullary erythropoiesis with anemia, which could mask important phenotypes. To overcome this drawback in mice, here we established in vitro and in vivo rat models for the studies of stress ...
Zhang J +7 more
europepmc +4 more sources
Governing roles for Trib3 pseudokinase during stress erythropoiesis. [PDF]
Exp Hematol, 2017 In response to anemia, the heightened production of erythropoietin (EPO) can sharply promote erythroid progenitor cell (EPC) formation. Specific mediators of such EPO- accelerated erythropoiesis, however, are not well understood. Presently, we first report that the expression of Trib3 in adult bone marrow EPCs in vivo is nominal at steady state, but ...
Dev A +6 more
europepmc +4 more sources
Reappraising the role of α5 integrin and the microenvironmental support in stress erythropoiesis. [PDF]
Exp Hematol, 2020 We previously studied the role of β1 integrin and some of its different α partners relevant to erythropoiesis. Although clear and consistent answers regarding the role of α4β1 (VLA-4) were evident, the role of its companion integrin α5β1 (VLA-5) was clouded by inconsistent outcomes in all prior publications.
Ulyanova T +2 more
europepmc +4 more sources
Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. [PDF]
PLoS ONE, 2010 BACKGROUND: Definitive erythropoiesis is a vital process throughout life. Both its basal activity under physiological conditions and its increased activity under anemia-induced stress conditions are highly stimulated by the hormone erythropoietin.
Bogdan Dumitriu +6 more
doaj +2 more sources
β-Thalassemia and Polycythemia vera: Targeting chronic stress erythropoiesis [PDF]
International Journal of Biochemistry and Cell Biology, 2014 β-Thalassemia and Polycythemia vera are genetic disorders which affect the synthesis of red blood cells, also referred to as erythropoiesis. Although essentially different in clinical presentation - patients with β-thalassemia have an impairment in β-globin synthesis leading to defective erythrocytes and anemia, while patients with Polycythemia vera ...
Stefano Rivella, Bart J Crielaard
exaly +3 more sources
Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome [PDF]
Cell ReportsSummary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions.
Micah G. Donovan +14 more
doaj +2 more sources
Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis. [PDF]
PLoS ONE, 2010 Mammals are able to rapidly produce red blood cells in response to stress. The molecular pathways used in this process are important in understanding responses to anaemia in multiple biological settings.
Pamela D Thompson +6 more
doaj +3 more sources
Metabolic gatekeeping in murine stress erythropoiesis. [PDF]
Blood Red Cells IronSerra M, Blanc L.
europepmc +2 more sources
An acetate switch regulates stress erythropoiesis [PDF]
Nature Medicine, 2014 The hormone erythropoietin (EPO), which is synthesized in the kidney or liver of adult mammals, controls erythrocyte production and is regulated by the stress-responsive transcription factor hypoxia-inducible factor-2 (HIF-2). We previously reported that the lysine acetyltransferase CREB-binding protein (CBP) is required for HIF-2α acetylation and ...
Min, Xu +12 more
openaire +3 more sources