Results 11 to 20 of about 2,700,982 (237)
Stress erythropoiesis in atherogenic mice. [PDF]
Sci Rep, 2020 AbstractBone marrow erythropoiesis is mainly homeostatic and a demand of oxygen in tissues activates stress erythropoiesis in the spleen. Here, we show an increase in the number of circulating erythrocytes in apolipoprotein E−/− mice fed a Western high-fat diet, with similar number of circulating leukocytes and CD41+ events (platelets).
Sánchez Á +5 more
europepmc +9 more sources
Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis [PDF]
Medicinski PodmladakErythropoiesis under basal conditions involves the continuous production of new erythrocytes at a constant rate. During the adult period, erythropoiesis takes place primarily in the bone marrow and has a substantial capacity.
Momčilović Sanja +2 more
doaj +4 more sources
Chronic restraint stress upregulates erythropoiesis through glucocorticoid stimulation. [PDF]
PLoS ONE, 2013 In response to elevated glucocorticoid levels, erythroid progenitors rapidly expand to produce large numbers of young erythrocytes. Previous work demonstrates hematopoietic changes in rodents exposed to various physical and psychological stressors ...
Jeffrey L Voorhees +5 more
doaj +4 more sources
The macrophage contribution to stress erythropoiesis: when less is enough [PDF]
Blood, 2016 Key PointsSignificant expansion only of native splenic macrophages that are F4/80+/Cd11blo occurs in both post-Epo and post–hemolysis-induced stress. VCAM-1−/− mice, like Spi-C−/−, mice have significantly decreased macrophages but did not have a compromised E-stress response.
Thalia Papayannopoulou
exaly +4 more sources
Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis [PDF]
Journal of Family Medicine and Primary Care, 2023 A 70-year-old male with a known case of beta-thalassemia trait and was on yearly follow-up was found to have a hemoglobin of 14.8 g/dL, hematocrit of 47.7%, and RBC count of 6.0 × 1012/L. Total leukocyte count (TLC) was 5 × 109/L and platelet count was 4
Afaq A. Khan +4 more
doaj +2 more sources
E-cadherin/β-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis. [PDF]
Blood Adv, 2023 Abstract E-cadherin is a crucial regulator of epithelial cell-to-cell adhesion and an established tumor suppressor. Aside epithelia, E-cadherin expression marks the erythroid cell lineage during human but not mouse hematopoiesis. However, the role of E-cadherin in human erythropoiesis remains unknown.
Krimpenfort RA +8 more
europepmc +4 more sources
Stress Erythropoiesis Model Systems. [PDF]
Methods Mol Biol, 2018 Bone marrow steady-state erythropoiesis maintains erythroid homeostasis throughout life. This process constantly generates new erythrocytes to replace the senescent erythrocytes that are removed by macrophages in the spleen. In contrast, anemic or hypoxic stress induces a physiological response designed to increase oxygen delivery to the tissues ...
Bennett LF, Liao C, Paulson RF.
europepmc +4 more sources
Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. [PDF]
PLoS ONE, 2015 Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood.
Min Liu +5 more
doaj +2 more sources
Exposure to hypoxia causes stress erythropoiesis and downregulates immune response genes in spleen of mice [PDF]
BMC Genomics, 2021 Background The spleen is the largest secondary lymphoid organ and the main site where stress erythropoiesis occurs. It is known that hypoxia triggers the expansion of erythroid progenitors; however, its effects on splenic gene expression are still ...
Haijing Wang +5 more
doaj +2 more sources
The Rb tumor suppressor is required for stress erythropoiesis [PDF]
EMBO Journal, 2004 The retinoblastoma tumor suppressor gene plays important roles in cell cycle control, differentiation and survival during development and is functionally inactivated in most human cancers. Early studies using gene targeting in mice suggested a critical role for pRb in erythropoiesis, while more recent experiments have suggested that many of the ...
Tyler E Jacks +2 more
exaly +3 more sources