Results 31 to 40 of about 2,700,982 (237)
Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis. [PDF]
Am J Hematol, 2019 The signaling cascade induced by the interaction of erythropoietin (EPO) with its receptor (EPO-R) is a key event of erythropoiesis. We present here data indicating that Fyn, a Src-family-kinase, participates in the EPO signaling-pathway, since Fyn ...
Beneduce E +14 more
europepmc +4 more sources
Overexpression of MyrAkt1 in endothelial cells leads to erythropoietin- and BMP4-independent splenic erythropoiesis in mice. [PDF]
PLoS ONE, 2013 Under steady state conditions, erythropoiesis occurs in the bone marrow. However, in mice, stress or tissue hypoxia results in increased erythropoiesis in the spleen.
Rebekah K O'Donnell +4 more
doaj +1 more source
Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. [PDF]
PLoS ONE, 2010 Bone marrow erythropoiesis is primarily homeostatic, producing new erythrocytes at a constant rate. However at times of acute anemia, new erythrocytes must be rapidly produced much faster than bone marrow steady state erythropoiesis.
Dai-Chen Wu, Robert F Paulson
doaj +1 more source
Adrenergic Modulation of Erythropoiesis After Trauma
Frontiers in Physiology, 2022 Severe traumatic injury results in a cascade of systemic changes which negatively affect normal erythropoiesis. Immediately after injury, acute blood loss leads to anemia, however, patients can remain anemic for as long as 6 months after injury. Research
Jennifer A. Munley +2 more
doaj +1 more source
G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation
Life Science Alliance, 2021 Granulocyte colony-stimulating factor suppresses erythropoiesis of bone marrow and promotes splenic erythropoiesis during lipopolysaccharide-induced systemic inflammation in mice.
Weiqiang Jing +9 more
doaj +1 more source
The glucocorticoid receptor is required for stress erythropoiesis [PDF]
Genes & Development, 1999 The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vivo, using GR-deficient mice or mice expressing a GR defective for transactivation.
A, Bauer +7 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Erythroblastic islands (EBIs), discovered more than 60 years ago, are specialized microenvironments for erythropoiesis. This island consists of a central macrophage with surrounding developing erythroid cells.
Wei Li +3 more
doaj +1 more source
Stress erythropoiesis: selenium to the rescue! [PDF]
Blood, 2018 Studies investigating how micronutrients regulate erythropoiesis within the erythroblastic niche have primarily focused on iron homeostasis. In this issue of Blood , Liao et al highlight an additional regulator of the erythroblastic niche, selenium (Se).
Brian M. Dulmovits, Lionel Blanc
openaire +2 more sources
Receptor-mediated mitophagy regulates EPO production and protects against renal anemia
eLife, 2021 Erythropoietin (EPO) drives erythropoiesis and is secreted mainly by the kidney upon hypoxic or anemic stress. The paucity of EPO production in renal EPO-producing cells (REPs) causes renal anemia, one of the most common complications of chronic ...
Guangfeng Geng +15 more
doaj +1 more source
The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]
, 1974 For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core +1 more source