NEDDylation promotes stress granule assembly [PDF]
Nature Communications, 2016 Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to
Aravinth Kumar Jayabalan +8 more
doaj +5 more sources
Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
doaj +3 more sources
Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes [PDF]
Cell ReportsSummary: Stress granules are a conserved response of eukaryotic cells to environmental insults. These cytoplasmic ribonucleoprotein condensates have hitherto been primarily studied by microscopy, which showed previously that they comprise dense ∼200 nm ...
Natalia A. Demeshkina +1 more
doaj +2 more sources
Stress granules dynamics: benefits in cancer
BMB Reports, 2022 Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and ...
Jeong In Lee, Sim Namkoong
openalex +4 more sources
DEAD-Box Helicase 3 Modulates the Non-Coding RNA Pool in Ribonucleoprotein Condensates During Stress Granule Formation [PDF]
Non-Coding RNAStress granule formation is a type of liquid–liquid phase separation in the cytoplasm, leading to RNA–protein condensates that are associated with various cellular stress responses and implicated in numerous pathologies, including cancer ...
Elizaveta Korunova +7 more
doaj +2 more sources
Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 [PDF]
Nature CommunicationsNon-covalent interactions of poly(ADP-ribose) (PAR) facilitate condensate formation, yet the impact of these interactions on condensate properties remains unclear.
Shang-Jung Cheng +8 more
doaj +2 more sources
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination [PDF]
Nature CommunicationsThe NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon +12 more
doaj +2 more sources
Stress granule-defective mutants deregulate stress responsive transcripts.
PLoS Genetics, 2014 To reduce expression of gene products not required under stress conditions, eukaryotic cells form large and complex cytoplasmic aggregates of RNA and proteins (stress granules; SGs), where transcripts are kept translationally inert.
Xiaoxue Yang +9 more
doaj +3 more sources
RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Stress granules, which are ubiquitous, non–membrane-bound assemblies of protein and RNA, form when translation initiation is inhibited, contribute to the regulation of gene expression, and are implicated in the pathologies of cancer and neurodegenerative disease. Understanding the mechanisms of stress
Tyler Matheny +2 more
exaly +3 more sources
RNF144A-VRK2-G3BP1 axis regulates stress granule assembly [PDF]
Cell Death DiscoveryUnder the cellular stress, stress granules (SGs) help survival and proliferation of the cell. Unfortunately, the same SGs help unwanted cancer cells under stressful environment, including anti-cancer chemotherapy treatment.
Sung Wook Kim +5 more
doaj +2 more sources