Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes [PDF]
Cell ReportsSummary: Stress granules are a conserved response of eukaryotic cells to environmental insults. These cytoplasmic ribonucleoprotein condensates have hitherto been primarily studied by microscopy, which showed previously that they comprise dense ∼200 nm ...
Natalia A. Demeshkina +1 more
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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 [PDF]
Nature CommunicationsNon-covalent interactions of poly(ADP-ribose) (PAR) facilitate condensate formation, yet the impact of these interactions on condensate properties remains unclear.
Shang-Jung Cheng +8 more
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NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination [PDF]
Nature CommunicationsThe NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon +12 more
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RNF144A-VRK2-G3BP1 axis regulates stress granule assembly [PDF]
Cell Death DiscoveryUnder the cellular stress, stress granules (SGs) help survival and proliferation of the cell. Unfortunately, the same SGs help unwanted cancer cells under stressful environment, including anti-cancer chemotherapy treatment.
Sung Wook Kim +5 more
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Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress [PDF]
eLifeCells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA ...
Showkat Ahmad Dar +9 more
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Establishment of a stress granule reporter system for evaluating in vitro colon toxicity [PDF]
Animal Cells and SystemsExposure to toxic molecules from food or oral medications induces toxicity in colon cells that cause various human diseases; however, in vitro monitoring systems for colon cell toxicity are not well established.
Namjoon Cho +3 more
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Frontiers in Cell and Developmental Biology, 2021 Metabolic regulation is a necessary component of all stress response pathways, because all different mechanisms of stress-adaptation place high-energy demands on the cell.
Triana Amen +2 more
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Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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A Hybrid-Body Containing Constituents of Both P-Bodies and Stress Granules Forms in Response to Hypoosmotic Stress in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2016 The cytoplasm of the eukaryotic cell is a highly compartmentalized space that contains a variety of ribonucleoprotein (RNP) granules in addition to its complement of membrane-bound organelles.
Khyati H Shah +3 more
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Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells
Frontiers in Microbiology, 2022 Stress granule formation is induced by numerous environmental stressors, including sodium arsenite treatment and viral infection. Accordingly, stress granules can inhibit viral propagation and function as part of the antiviral host response to numerous ...
Dongbum Kim +11 more
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