Results 1 to 10 of about 72,065 (313)

Nuclear stress granules [PDF]

The Journal of Cell Biology, 2004
Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one
Anton Sandqvist, Lea Sistonen
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EGFP-FMRP Granules Are Proto-Granules That Can Be Shunted to Stress Granules During a Stress Response [PDF]

Nature Precedings, 2010
AbstractOverexpressed EGFP-FMRP has been used as a substitute for endogenous fragile X mental retardation protein (FMRP) in protein-protein interaction studies, and in studies concerning the composition, the formation and the localization of neuronal granules.
Robert B. Denman, Robert B. Denman
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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 [PDF]

Nature Communications
Non-covalent interactions of poly(ADP-ribose) (PAR) facilitate condensate formation, yet the impact of these interactions on condensate properties remains unclear.
Shang-Jung Cheng, Temitope Gafaar, Jijin R. A. Kuttiyatveetil, Aleksandr Sverzhinsky, Carla Chen, Minghui Xu, Allison Lilley, John M. Pascal, Anthony K. L. Leung   +8 more
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NEDDylation promotes stress granule assembly [PDF]

Nature Communications, 2016
Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to
Aravinth Kumar Jayabalan, Anthony Sanchez, Ra Young Park, Sang Pil Yoon, Gum-Yong Kang, Je-Hyun Baek, Paul Anderson, Younghoon Kee, Takbum Ohn   +8 more
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NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination [PDF]

Nature Communications
The NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon, Hyun-Ji Ham, Haneul Choi, Semin Park, Jae-Woo Jang, Sang-Won Park, Dong-Hyung Cho, Hyun-Jeong Lee, Hyun Kyu Song, Masaaki Komatsu, Dohyun Han, Deok-Jin Jang, Jin-A Lee   +12 more
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Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]

Cell Stress, 2019
Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
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Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress [PDF]

eLife
Cells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA ...
Showkat Ahmad Dar, Sulochan Malla, Vlastimil Martinek, Matthew John Payea, Christopher Tai-Yi Lee, Jessica Martin, Aditya Jignesh Khandeshi, Jennifer L Martindale, Cedric Belair, Manolis Maragkakis   +9 more
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RNF144A-VRK2-G3BP1 axis regulates stress granule assembly [PDF]

Cell Death Discovery
Under the cellular stress, stress granules (SGs) help survival and proliferation of the cell. Unfortunately, the same SGs help unwanted cancer cells under stressful environment, including anti-cancer chemotherapy treatment.
Sung Wook Kim, Jae Lee, Kyung Won Jo, Young-Hun Jeong, Won Sik Shin, Kyong-Tai Kim   +5 more
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Establishment of a stress granule reporter system for evaluating in vitro colon toxicity [PDF]

Animal Cells and Systems
Exposure to toxic molecules from food or oral medications induces toxicity in colon cells that cause various human diseases; however, in vitro monitoring systems for colon cell toxicity are not well established.
Namjoon Cho, Da-Min Jung, Eun-Mi Kim, Kee K. Kim   +3 more
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Bacterial stress granule protects mRNA through ribonucleases exclusion [PDF]

arXiv
Membraneless droplets formed through liquid-liquid phase separation (LLPS) play a crucial role in mRNA storage, enabling organisms to swiftly respond to environmental changes. However, the mechanisms underlying mRNA integration and protection within droplets remain unclear.
Pei L, Xian Y, Yan X, Schaefer C, Syeda AH, Howard JAL, Liao H, Bai F, Leake MC, Pu Y.   +9 more
europepmc   +2 more sources