Results 31 to 40 of about 72,065 (313)
Shigella flexnerimodulates stress granule composition and inhibits stress granule aggregation [PDF]
Cellular Microbiology, 2016 Invasion and multiplication of the facultative, cytosolic, enteropathogen Shigella flexneri within the colonic epithelial lining leads to an acute inflammatory response, fever and diarrhea. During the inflammatory process, infected cells are subjected to numerous stresses including heat, oxidative stress and genotoxic stress.
Philippe J. Sansonetti +5 more
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, 2020 The capacity of cells to organize complex biochemical reactions in intracellular space is a fundamental organizational principle of life. Key to this organization is the compartmentalization of the cytoplasm into distinct organelles, which is frequently achieved through intracellular membranes.
Min-Seok Song, Elda Grabocka
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Detecting Stress Granules in Drosophila Neurons [PDF]
, 2022 Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates that dynamically and reversibly assemble in response to stress. They are thought to contribute to the adaptive stress response by storing translationally inactive mRNAs as well as signaling molecules.
de Graeve, Fabienne +6 more
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Regulated protein aggregation: stress granules and neurodegeneration
Molecular Neurodegeneration, 2012 The protein aggregation that occurs in neurodegenerative diseases is classically thought to occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts with the biology of RNA binding proteins, many of which are linked to
Wolozin Benjamin
doaj +1 more source
Cell Cycle, 2012 Cell growth and proliferation are fundamental processes in living organisms and are dynamically controlled by environmental cues. TOR complex 1 (TORC1) is a central protein kinase involved in the regulation of cell growth in response to a wide variety of cellular states and is the target of the immunosuppressant and anticancer drug rapamycin.
Tatsuya Maeda, Terunao Takahara
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Aspergillus oryzae AoSO is a novel component of stress granules upon heat stress in filamentous fungi. [PDF]
PLoS ONE, 2013 Stress granules are a type of cytoplasmic messenger ribonucleoprotein (mRNP) granule formed in response to the inhibition of translation initiation, which typically occurs when cells are exposed to stress.
Hsiang-Ting Huang +2 more
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The prion-like protein kinase Sky1 is required for efficient stress granule disassembly
Nature Communications, 2019 The factors regulating stress granule dissolution are not fully understood. Here, the authors identify Sky1 as a stress granule component in yeast, and show that Sky1 kinase activity is required for timely stress granule disassembly during stress ...
Jenifer E. Shattuck +3 more
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Dilatancy, Jamming, and the Physics of Granulation [PDF]
J. Phys.: Condens. Matter 17, S2517-S2531 (2005), 2004 Granulation is a process whereby a dense colloidal suspension is converted into pasty granules (surrounded by air) by application of shear. Central to the stability of the granules is the capillary force arising from the interfacial tension between solvent and air.
arxiv +1 more source
Stress Granules and Virus Replication [PDF]
Future Virology, 2011 Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. This results in inhibition of translation and is intended to block virus replication.
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Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling
Viruses, 2020 Viruses must hijack cellular translation machinery to express viral genes. In many cases, this is impeded by cellular stress responses. These stress responses result in the global inhibition of translation and the storage of stalled mRNAs, into RNA ...
Matthew J. Brownsword +4 more
doaj +1 more source