Results 31 to 40 of about 129,858 (349)

Plant Stress Granules: Trends and Beyond [PDF]

Frontiers in Plant Science, 2021
Stress granules (SGs) are dynamic membrane-less condensates transiently assembled through liquid–liquid phase separation (LLPS) in response to stress. SGs display a biphasic architecture constituted of core and shell phases. The core is a conserved SG fraction fundamental for its assembly and consists primarily of proteins with intrinsically disordered
Maruri Lopez, Israel, Figueroa, Nicolas E., Hernandez-Sanchez, Itzell E., Chodasiewicz, Monika   +3 more
openaire   +4 more sources

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress [PDF]

, 2015
The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/
A Dupre, A Gulino, A Kuzyk, A Shibata, A Soriani, A Wey, A Wey, AM Duursma, AM Taylor, B Argenti, B Ricci, B Shiotani, BR Stanton, C Bruhn, C Heil, CJ Thiele, CL Marcelis, D Dominguez-Sola, D Fruci, DW Felsher, EA Rahal, F Sardina, G Giannini, G Giannini, H van Bokhoven, HE Bryant, I Screpanti, J Buis, J Charron, J Lafrance-Vanasse, J Wu, K Schlacher, K Trenz, KA Cole, KH Chrzanowska, KK To, L Di Marcotullio, LJ Valentijn, M Cognet, M Murga, M Petroni, M Petroni, M Sahún-Roncero, M Wilda, M Wojewodzka, O Chayka, P Khongkow, PE Neiman, PJ Hurlin, PO Frappart, PS Knoepfler, R Moser, R Thompson, R Waltes, RS Williams, RV Pusapati, S Albini, S Biton, S Ray, S Rohban, S Sawai, S Ying, SV Srinivasan, TG Oliver, TH Stracker, V Colicchia, V Veschi, V Veschi, W Lutz, YC Chiang, YL Lin   +70 more
core   +1 more source

Stress Granules in Cancer

, 2020
The capacity of cells to organize complex biochemical reactions in intracellular space is a fundamental organizational principle of life. Key to this organization is the compartmentalization of the cytoplasm into distinct organelles, which is frequently achieved through intracellular membranes.
Min-Seok, Song, Elda, Grabocka
openaire   +3 more sources

Assessing the microstructural and rheological changes induced by food additives on potato puree [PDF]

, 2018
The effects of agar, alginate, lecithin and glycerol on the rheological properties of commercial potato puree were investigated and interpreted in terms of starch microstructural changes, and the applicability of the Cox-Merz rule was evaluated.
Dankar, Iman, El Omar, Fawaz, Haddarah, Amira, Pujolà Cunill, Montserrat, Sepulcre Sánchez, Francesc   +4 more
core   +2 more sources

The prion-like protein kinase Sky1 is required for efficient stress granule disassembly

Nature Communications, 2019
The factors regulating stress granule dissolution are not fully understood. Here, the authors identify Sky1 as a stress granule component in yeast, and show that Sky1 kinase activity is required for timely stress granule disassembly during stress ...
Jenifer E. Shattuck, Kacy R. Paul, Sean M. Cascarina, Eric D. Ross   +3 more
doaj   +1 more source

Regulated protein aggregation: stress granules and neurodegeneration

Molecular Neurodegeneration, 2012
The protein aggregation that occurs in neurodegenerative diseases is classically thought to occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts with the biology of RNA binding proteins, many of which are linked to
Wolozin Benjamin
doaj   +1 more source

Wet granulation in laboratory scale high shear mixers: Effect of binder properties [PDF]

, 2011
The effect of binder properties on torque curves, granule growth kinetics, wet mass consistency and dry granule strength has been investigated in this study.
Chitu, Toma Mihai, Hemati, Mehrdji, Oulahna, Driss   +2 more
core   +3 more sources

Using small-angle X-ray scattering to investigate the compaction behaviour of a granulated clay [PDF]

, 2015
The compaction behaviour of a commercial granulated clay (magnesium aluminium smectite, gMgSm) was investigated using macroscopic pressure-density measurements, X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray microtomography (XμT) and ...
Aguzzi, Asare-Addo, Aulton, Baille, Barbara R. Conway, Baruchel, Beckett, Berisso, Briscoe, Busignies, Chipera, Djemai, Enes Šupuk, Feigin, Francis Sweeney, German, Hammond, Han, Ito, Kandeil, Kim, Kofi Asare-Addo, Kuklíc, Laity, Laity, Laity, Laity, Laity, Laity, Laity, Liddiard, Macleod, Mc.Donald, Mondol, Morel, Moyano, Murray, Nebgen, Oh, Peter R. Laity, Pizette, Pongjanyakul, Prakash, Rahaman, Roe, Romero, Schmidt, Sinka, Sinka, Sorensen, Stock, Sun, Tien, Train, Vanorio, Villamizar, Villar, Villar, Wu, Ye   +59 more
core   +1 more source

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics [PDF]

, 2017
Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules.
Abigail M. Janke, Aguzzi, Albert Konijnenberg, Alex Volkov, Altmeyer, Andersen, Ash, Aumiller, Boeynaems, Boeynaems, Brangwynne, Brangwynne, Brangwynne, Burke, Castello, Ciryam, Conicella, Cox, Cox, David, DeJesus-Hernandez, Denes Kovacs, Dirk Daelemans, Dormann, Edbauer, Elke Bogaert, Emara, Evy Timmerman, Figley, Francis Impens, Frank Sobott, Frederic Rousseau, Freibaum, Frey, Hawe, Hennig, J. Paul Taylor, Jain, Joost Schymkowitz, Jovičić, Kato, Kedersha, Kedersha, Kedersha, Kim, King, Kwon, Lee, Lin, Lin, Liu, Lopez-Gonzalez, Ludo Van Den Bosch, Mainak Guharoy, March, Mathias De Decker, Mitrea, Mizielinska, Molliex, Mori, Murakami, Nancy Kedersha, Nicolas L. Fawzi, Nott, Olzscha, Patel, Paul Anderson, Peter Tompa, Philip Van Damme, Pieter Baatsen, Ramaswami, Regina-Maria Kolaitis, Renton, Renton, Schwartz, Steven Boeynaems, Tao, Thandapani, Thomas Vercruysse, Tiraferri, Tom Jaspers, Tompa, Tompa, Topisirovic, Varadi, Veronica H. Ryan, Wen, Wheeler, Wim Robberecht, Yamakawa, Zhang   +90 more
core   +4 more sources

Stress Granules and Virus Replication [PDF]

Future Virology, 2011
Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. This results in inhibition of translation and is intended to block virus replication.
openaire   +2 more sources