Results 41 to 50 of about 72,065 (313)
Cell Reports, 2017 Most cellular stresses induce protein translation inhibition and stress granule formation. Here, using Drosophila S2 cells, we investigate the role of G3BP/Rasputin in this process.
Angelica Aguilera-Gomez +9 more
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Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2010 The regulation of translation and mRNA degradation in eukaryotic cells involves the formation of cytoplasmic mRNP granules referred to as P-bodies and stress granules.
Kylie D Swisher, Roy Parker
doaj +1 more source
Granule structure influences on force chain development in the slag medium
地质科技通报, 2022 The slag dumps formed by mining activities are irregular granular media. Their particle size gradations are complex and granule structures are unstable.The stress between particles is transferred through the dependently unstable force chain.
Minfeng Lu +5 more
doaj +1 more source
Viral modulation of stress granules
Virus Research, 2012 Following viral infection, the host responds by mounting a robust anti-viral response with the aim of creating an unfavorable environment for viral replication. As a countermeasure, viruses have elaborated mechanisms to subvert the host response in order to maintain viral protein synthesis and production.
Fernando Valiente-Echeverría +4 more
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Stress granule formation via ATP depletion-triggered phase separation [PDF]
New Journal of Physics 20, 045008 (2018), 2017 Stress granules (SG) are droplets of proteins and RNA that form in the cell cytoplasm during stress conditions. We consider minimal models of stress granule formation based on the mechanism of phase separation regulated by ATP-driven chemical reactions. Motivated by experimental observations, we identify a minimal model of SG formation triggered by ATP
arxiv +1 more source
Stress granule transcription [PDF]
Science, 2018 Molecular Biology When translation initiation is stalled under stress, nontranslating messenger ribonucleoproteins form insoluble assemblies called stress granules (SGs) in the cytosol. Namkoong et al. sequenced all transcripts from purified SGs. They found that although translation of most transcripts is inhibited, only a subset of transcripts form ...
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Getting stress out of stressed‐out stress granules [PDF]
The EMBO Journal, 2017 Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal , Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase ...
Pratibha Siwach, Daniel Kaganovich
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Stress Granules in the Viral Replication Cycle [PDF]
Viruses, 2011 As intracellular parasites, viruses require a host cell in order to replicate. However, they face a series of cellular responses against infection. One of these responses is the activation of the double-stranded RNA (dsRNA)-activated protein kinase R (PKR). PKR phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), which in
Hilda Montero, Vicenta Trujillo-Alonso
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A switch for stress granule assembly [PDF]
Journal of Cell Biology, 2016 ![Figure][1] Cells overexpressing USP10 (green) fail to form stress granules (magenta) when translation initiation is inhibited. [Kedersha et al.][2] describe how phosphorylation and the competition between mutually exclusive binding partners regulate G3BP’s ability to mediate ...
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Hypoxia-induced mitochondrial stress granules
Cell Death & Disease, 2023 AbstractPerturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia-induced mitochondrial protein aggregation in C. elegans, we found that sublethal hypoxia, sodium azide, or heat shock-induced abundant ethidium bromide staining mitochondrial granules
Chun-Ling Sun +2 more
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