Results 51 to 60 of about 72,065 (313)

Regulation of stress granules in virus systems [PDF]

Trends in Microbiology, 2012
Virus infection initiates a number of cellular stress responses that modulate gene regulation and compartmentalization of RNA. Viruses must control host gene expression and the localization of viral RNAs to be successful parasites. RNA granules such as stress granules and processing bodies (PBs) contain translationally silenced messenger ...
James P. White, Richard E. Lloyd
openaire   +2 more sources

Distinct stages in stress granule assembly and disassembly

eLife, 2016
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell.
Joshua R Wheeler, Tyler Matheny, Saumya Jain, Robert Abrisch, Roy Parker   +4 more
doaj   +1 more source

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Stress granules, which are ubiquitous, non–membrane-bound assemblies of protein and RNA, form when translation initiation is inhibited, contribute to the regulation of gene expression, and are implicated in the pathologies of cancer and neurodegenerative disease.
Anthony Khong, Roy Parker, Christopher D. Link, Tyler Matheny, Briana Van Treeck, David S.W. Protter   +5 more
openaire   +2 more sources

Plant stress granules and mRNA processing bodies are distinct from heat stress granules [PDF]

The Plant Journal, 2008
SummarySimilar to the situation in mammalian cells and yeast, messenger ribonucleo protein (mRNP) homeostasis in plant cells depends on rapid transitions between three functional states, i.e. translated mRNPs in polysomes, stored mRNPs and mRNPs under degradation.
Markus Fauth, Christian Weber, Lutz Nover   +2 more
openaire   +2 more sources

Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. [PDF]

PLoS ONE, 2011
Chemotherapeutics and other pharmaceuticals are common sources of cellular stress. Darinaparsin (ZIO-101) is a novel organic arsenical under evaluation as a cancer chemotherapeutic, but the drug's precise mechanism of action is unclear.
Twila A Mason, Elena Kolobova, Jiang Liu, Joseph T Roland, Chin Chiang, James R Goldenring   +5 more
doaj   +1 more source

Multiple functions of stress granules in viral infection at a glance

Frontiers in Microbiology, 2023
Stress granules (SGs) are distinct RNA granules induced by various stresses, which are evolutionarily conserved across species. In general, SGs act as a conservative and essential self-protection mechanism during stress responses.
Yuelin Guan, Yan Wang, Xudong Fu, Xudong Fu, Guannan Bai, Xue Li, Jianhua Mao, Yongbin Yan, Lidan Hu   +8 more
doaj   +1 more source

Stress granules: functions and mechanisms in cancer

Cell & Bioscience, 2023
AbstractStress granules (SGs) are non-enveloped structures formed primarily via protein and RNA aggregation under various stress conditions, including hypoxia and viral infection, as well as oxidative, osmotic, and heat-shock stress. SGs assembly is a highly conserved cellular strategy to reduce stress-related damage and promote cell survival.
Huan Zhou, Jing Luo, Kelin Mou, Lin Peng, Xiaoyue Li, Yulin Lei, Jianmei Wang, Sheng Lin, Yuhao Luo, Li Xiang   +9 more
openaire   +3 more sources

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH

Open Biology, 2023
G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation ...
Tim Schulte, Marc D. Panas, Xiao Han, Lucy Williams, Nancy Kedersha, Jonas Simon Fleck, Timothy J. C. Tan, Xaquin Castro Dopico, Anders Olsson, Ainhoa Moliner Morro, Leo Hanke, Johan Nilvebrant, Kim Anh Giang, Per-Åke Nygren, Paul Anderson, Adnane Achour, Gerald M. McInerney   +16 more
doaj   +1 more source

Yielding, Rigidity, and Tensile Stress in Sheared Columns of Hexapod Granules [PDF]

Phys. Rev. E 101, 062903 (2020), 2020
Granular packings of non-convex or elongated particles can form free-standing structures like walls or arches. For some particle shapes, such as staples, the rigidity arises from interlocking of pairs of particles, but the origins of rigidity for non-interlocking particles remains unclear.
arxiv   +1 more source

Dynamics of mRNA entry into stress granules [PDF]

Nature Cell Biology, 2019
Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.
Geraldine Seydoux, Chih Yung S. Lee
openaire   +3 more sources