Results 61 to 70 of about 129,858 (349)

Viral modulation of stress granules

Virus Research, 2012
Following viral infection, the host responds by mounting a robust anti-viral response with the aim of creating an unfavorable environment for viral replication. As a countermeasure, viruses have elaborated mechanisms to subvert the host response in order to maintain viral protein synthesis and production.
Valiente-Echeverría, Fernando, Melnychuk, Luca, Mouland, Andrew J.   +2 more
openaire   +2 more sources

Stress granules, P-bodies and cancer [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2015
Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic ...
Paul, Anderson, Nancy, Kedersha, Pavel, Ivanov   +2 more
openaire   +2 more sources

Detecting Stress Granules in Drosophila Neurons [PDF]

, 2022
Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates that dynamically and reversibly assemble in response to stress. They are thought to contribute to the adaptive stress response by storing translationally inactive mRNAs as well as signaling molecules.
de Graeve, Fabienne, Formicola, Nadia, Pushpalatha, Kavya Vinayan, Nakamura, Akira, Debreuve, Eric, Descombes, Xavier, Besse, Florence   +6 more
openaire   +3 more sources

A novel G3BP1-GFP reporter human lung cell system enabling real-time monitoring of stress granule dynamics for in vitro lung toxicity assessment

Ecotoxicology and Environmental Safety
Under various cellular stress conditions, including exposure to toxic chemicals, RNA-binding proteins (RBPs), including Ras GTPase-activating protein-binding protein 1 (G3BP1), aggregate and form stress granule complexes, which serve as hallmarks of ...
Sangsoo Lee, Seung-Yeon Kim, Eunhye Kwon, Sunkyung Choi, Da-Min Jung, Kee K. Kim, Eun-Mi Kim   +6 more
doaj   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

Stress granules: Guardians of cellular health and triggers of disease

Neural Regeneration Research
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs (mRNAs) and regulating protein synthesis.
Meghal Desai, Keya Gulati, Manasi Agrawal, Shruti Ghumra, Pabitra K. Sahoo   +4 more
doaj   +1 more source

Distinct stages in stress granule assembly and disassembly

eLife, 2016
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell.
Joshua R Wheeler, Tyler Matheny, Saumya Jain, Robert Abrisch, Roy Parker   +4 more
doaj   +1 more source

Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition

iScience, 2020
Summary: Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule ...
Triana Amen, Daniel Kaganovich
doaj   +1 more source

Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. [PDF]

PLoS ONE, 2011
Chemotherapeutics and other pharmaceuticals are common sources of cellular stress. Darinaparsin (ZIO-101) is a novel organic arsenical under evaluation as a cancer chemotherapeutic, but the drug's precise mechanism of action is unclear.
Twila A Mason, Elena Kolobova, Jiang Liu, Joseph T Roland, Chin Chiang, James R Goldenring   +5 more
doaj   +1 more source