Results 61 to 70 of about 72,065 (313)
RNA Granules and Stress Granules in Virus Systems [PDF]
Journal of Bacteriology and Virology, 2012 Viruses initiate a number of cellular stress responses and modulate gene regulation and compartmentalization of RNA upon infection to be successful parasites. Virus infections may induce or impair stress granule (SG) formation to maximize replication efficiency.
openaire +1 more source
Stress granules regulate stress-induced paraspeckle assembly [PDF]
Journal of Cell Biology, 2019 Eukaryotic cells contain a variety of RNA-protein macrocomplexes termed RNP granules. Different types of granules share multiple protein components; however, the crosstalk between spatially separated granules remains unaddressed. Paraspeckles and stress granules (SGs) are prototypical RNP granules localized exclusively in the nucleus and cytoplasm ...
Jing Tong Tan +4 more
openaire +4 more sources
Stress granules at the intersection of autophagy and ALS [PDF]
Brain Research, 2016 Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease caused by loss of upper and lower motor neurons. The majority of ALS cases are classified as sporadic (80-90%), with the remaining considered familial based on patient history. The last decade has seen a surge in the identification of ALS-causing genes - including TARDBP (TDP-43), FUS,
Frank Shewmaker +2 more
openaire +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
eIF5A promotes translation elongation, polysome disassembly and stress granule assembly. [PDF]
PLoS ONE, 2010 Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate in cells exposed to environmental stress. We have identified ornithine decarboxylase (ODC), an enzyme required for polyamine synthesis, and eIF5A, a polyamine (hypusine ...
Chi Ho Li +4 more
doaj +1 more source
Stress granules as crucibles of ALS pathogenesis [PDF]
Journal of Cell Biology, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal human neurodegenerative disease affecting primarily motor neurons. Two RNA-binding proteins, TDP-43 and FUS, aggregate in the degenerating motor neurons of ALS patients, and mutations in the genes encoding these proteins cause some forms of ALS.
James Shorter +4 more
openaire +4 more sources
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Photoelastic Stress Response of Complex 3D-Printed Particle Shapes [PDF]
arXiv, 2022 While stress visualization within 3-dimensional particles would greatly advance our understanding of the behaviors of complex particles, traditional photoelastic methods suffer from a lack of available technology for producing suitable complex particles.
arxiv
Shear jamming and fragility in dense suspensions [PDF]
Granul. Matter, 21(3):82, 2019, 2019 The phenomenon of shear-induced jamming is a factor in the complex rheological behavior of dense suspensions. Such shear-jammed states are fragile, i.e., they are not stable against applied stresses that are incompatible with the stress imposed to create them.
arxiv +1 more source
Stress granules dynamics: benefits in cancer
BMB Reports, 2022 Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and ...
Jeong In Lee, Sim Namkoong
openaire +2 more sources