Stress Granules in Cancer. [PDF]
Rev Physiol Biochem Pharmacol, 2023 The capacity of cells to organize complex biochemical reactions in intracellular space is a fundamental organizational principle of life. Key to this organization is the compartmentalization of the cytoplasm into distinct organelles, which is frequently achieved through intracellular membranes.
Song MS, Grabocka E.
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Stress granules: functions and mechanisms in cancer. [PDF]
Cell Biosci, 2023 AbstractStress granules (SGs) are non-enveloped structures formed primarily via protein and RNA aggregation under various stress conditions, including hypoxia and viral infection, as well as oxidative, osmotic, and heat-shock stress. SGs assembly is a highly conserved cellular strategy to reduce stress-related damage and promote cell survival.
Zhou H +9 more
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NEDDylation promotes stress granule assembly [PDF]
Nature Communications, 2016 Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to
Aravinth Kumar Jayabalan +8 more
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Ar s enite treatment induces Hsp90 aggregates distinct from conventional stress granules in fission yeast [PDF]
Microbial CellVarious stress conditions, such as heat stress (HS) and oxidative stress, can cause biomolecular condensates represented by stress granules (SGs) via liquid-liquid phase separation.
Naofumi Tomimoto +2 more
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Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
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Stress Granules in the Viral Replication Cycle [PDF]
Viruses, 2011 As intracellular parasites, viruses require a host cell in order to replicate. However, they face a series of cellular responses against infection. One of these responses is the activation of the double-stranded RNA (dsRNA)-activated protein kinase R ...
Hilda Montero, Vicenta Trujillo-Alonso
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Critical role of G3BP1 in bovine parainfluenza virus type 3 (BPIV3)-inhibition of stress granules formation and viral replication [PDF]
Frontiers in ImmunologyBackgroundIt remains unclear whether BPIV3 infection leads to stress granules formation and whether G3BP1 plays a role in this process and in viral replication.
Nian Liu +10 more
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The Journal of Cell Biology, 2004 Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one
Anton Sandqvist, Lea Sistonen
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EGFP-FMRP Granules Are Proto-Granules That Can Be Shunted to Stress Granules During a Stress Response [PDF]
Nature Precedings, 2010 AbstractOverexpressed EGFP-FMRP has been used as a substitute for endogenous fragile X mental retardation protein (FMRP) in protein-protein interaction studies, and in studies concerning the composition, the formation and the localization of neuronal granules.
Robert B. Denman, Robert B. Denman
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Editorial: The Dynamics of Stress Granules [PDF]
Frontiers in Cell and Developmental Biology, 2021 Subhash Mehto +6 more
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