Results 11 to 20 of about 4,058,220 (323)
Hypoxia-induced mitochondrial stress granules
Cell Death and Disease, 2023 Perturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia-induced mitochondrial protein aggregation in C.
Chun-Ling Sun +2 more
doaj +3 more sources
The autophagy of stress granules
FEBS Letters, 2023 Our understanding of stress granule (SG) biology has deepened considerably in recent years, and with this, increased understanding of links has been made between SGs and numerous neurodegenerative diseases. One of the proposed mechanisms by which SGs and
Laura Ryan, D. C. Rubinsztein
semanticscholar +4 more sources
Plant Stress Granules: Trends and Beyond [PDF]
Frontiers in Plant Science, 2021 Stress granules (SGs) are dynamic membrane-less condensates transiently assembled through liquid–liquid phase separation (LLPS) in response to stress. SGs display a biphasic architecture constituted of core and shell phases.
I. Maruri-López +3 more
semanticscholar +5 more sources
Stress granules dynamics: benefits in cancer
BMB Reports, 2022 Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ...
Jeong‐In Lee, Sim Namkoong
semanticscholar +3 more sources
NEDDylation promotes stress granule assembly [PDF]
Nature Communications, 2016 Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to
Aravinth Kumar Jayabalan +8 more
doaj +5 more sources
Stress granules: regulators or by‐products?
The FEBS Journal, 2021 Cells have to deal with conditions that can cause damage to biomolecules and eventually cell death. To protect against these adverse conditions and promote recovery, cells undergo dramatic changes upon exposure to stress.
Daniel Matějů, J. Chao
semanticscholar +3 more sources
Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
doaj +3 more sources
Stress granules and neurodegeneration [PDF]
Nature Reviews Neuroscience, 2019 Recent advances suggest that the response of RNA metabolism to stress has an important role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral sclerosis, frontotemporal dementias and Alzheimer disease. RNA-binding proteins (RBPs) control the utilization of mRNA during stress, in part through the formation of ...
B. Wolozin, P. Ivanov
semanticscholar +3 more sources
Translation landscape of stress granules. [PDF]
Sci AdvAbstract Stress granules, cytoplasmic assemblies of RNA-binding proteins and mRNAs formed during cellular stress, are implicated in translational control. However, their exact functions remain elusive. Here, we employed cryogenic correlative light and electron microscopy to visualize stress granules in their native environment and reconstructed
Wu Y +7 more
europepmc +3 more sources
Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
doaj +1 more source