Results 41 to 50 of about 90,512 (310)
Stress Granules and Virus Replication [PDF]
Future Virology, 2011 Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. This results in inhibition of translation and is intended to block virus replication.
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Development of a novel light-up probe for detection of G-quadruplexes in stress granules
Scientific Reports, 2022 G-quadruplexes (G4s) regulate various biological processes in cells. However, cellular imaging of dynamically forming G4s in biomolecular condensates using small molecules has been poorly investigated. Herein, we present a fluorescent light-up probe with
Keisuke Iida +4 more
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Biomolecular phase separation in stress granule assembly and virus infection
Acta Biochimica et Biophysica Sinica, 2023 Liquid-liquid phase separation (LLPS) has emerged as a crucial mechanism for cellular compartmentalization. One prominent example of this is the stress granule.
Liu Yi +3 more
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Viral modulation of stress granules
Virus Research, 2012 Following viral infection, the host responds by mounting a robust anti-viral response with the aim of creating an unfavorable environment for viral replication. As a countermeasure, viruses have elaborated mechanisms to subvert the host response in order to maintain viral protein synthesis and production.
Fernando Valiente-Echeverría +4 more
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Stress Granules in the Post-transcriptional Regulation of Immune Cells
Frontiers in Cell and Developmental Biology, 2021 Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response.
Nicolas Curdy +18 more
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Stress granule formation via ATP depletion-triggered phase separation [PDF]
New Journal of Physics 20, 045008 (2018), 2017 Stress granules (SG) are droplets of proteins and RNA that form in the cell cytoplasm during stress conditions. We consider minimal models of stress granule formation based on the mechanism of phase separation regulated by ATP-driven chemical reactions. Motivated by experimental observations, we identify a minimal model of SG formation triggered by ATP
arxiv +1 more source
Stress granule transcription [PDF]
Science, 2018 Molecular Biology When translation initiation is stalled under stress, nontranslating messenger ribonucleoproteins form insoluble assemblies called stress granules (SGs) in the cytosol. Namkoong et al. sequenced all transcripts from purified SGs. They found that although translation of most transcripts is inhibited, only a subset of transcripts form ...
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Getting stress out of stressed‐out stress granules [PDF]
The EMBO Journal, 2017 Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal , Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase ...
Pratibha Siwach, Daniel Kaganovich
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Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins
eLife, 2020 RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the C. elegans germ plasm.
Chih-Yung S Lee +5 more
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Genes and Diseases, 2022 Stress granules are non-membranous cytoplasmic foci induced by various stress conditions. It is a protective strategy used by cells to suppress overall translation during stress. In cancer cells, it was thought that the formation of stress granules could
Taobo Hu +3 more
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