Results 51 to 60 of about 90,512 (310)
Cells, 2022 Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon +3 more
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A switch for stress granule assembly [PDF]
Journal of Cell Biology, 2016 ![Figure][1] Cells overexpressing USP10 (green) fail to form stress granules (magenta) when translation initiation is inhibited. [Kedersha et al.][2] describe how phosphorylation and the competition between mutually exclusive binding partners regulate G3BP’s ability to mediate ...
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Neurobiology of Disease, 2022 Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes.
LiDan Hu +5 more
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Ribonucleoprotein Granules: Between Stress and Transposable Elements
Biomolecules, 2023 Transposable elements (TEs) are DNA sequences that can transpose and replicate within the genome, leading to genetic changes that affect various aspects of host biology.
Sungjin Moon, Sim Namkoong
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Cell Reports, 2023 Summary: Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response to stress without first requiring nuclear feedback.
Ke Zhang +14 more
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Regulation of stress granules in virus systems [PDF]
Trends in Microbiology, 2012 Virus infection initiates a number of cellular stress responses that modulate gene regulation and compartmentalization of RNA. Viruses must control host gene expression and the localization of viral RNAs to be successful parasites. RNA granules such as stress granules and processing bodies (PBs) contain translationally silenced messenger ...
James P. White, Richard E. Lloyd
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eLife, 2015 RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein aggregates or through phase separation into a liquid RNA/protein phase. Which model describes RNP granules in living cells is still unclear.
Sonja Kroschwald +7 more
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RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Stress granules, which are ubiquitous, non–membrane-bound assemblies of protein and RNA, form when translation initiation is inhibited, contribute to the regulation of gene expression, and are implicated in the pathologies of cancer and neurodegenerative disease.
Anthony Khong +5 more
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Dance with the Devil: Stress Granules and Signaling in Antiviral Responses
Viruses, 2020 Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation ...
Nina Eiermann +4 more
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Plant stress granules and mRNA processing bodies are distinct from heat stress granules [PDF]
The Plant Journal, 2008 SummarySimilar to the situation in mammalian cells and yeast, messenger ribonucleo protein (mRNP) homeostasis in plant cells depends on rapid transitions between three functional states, i.e. translated mRNPs in polysomes, stored mRNPs and mRNPs under degradation.
Markus Fauth +2 more
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