Results 51 to 60 of about 4,058,220 (323)
Sequestration of highly expressed mRNAs in cytoplasmic granules, P-bodies, and stress granules enhances cell viability. [PDF]
PLoS Genetics, 2012 Transcriptome analyses indicate that a core 10%-15% of the yeast genome is modulated by a variety of different stresses. However, not all the induced genes undergo translation, and null mutants of many induced genes do not show elevated sensitivity to ...
Anna Lavut, Dina Raveh
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Cell Reports, 2018 Summary: Stress granules are non-membranous structures that transiently form in the cytoplasm during cellular stress, where they promote translational repression of non-essential RNAs and modulate cell signaling by sequestering key signal transduction ...
Joseph B. Rayman +2 more
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Signal Transduction and Targeted Therapy, 2022 As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and spread.
Yi Zheng +11 more
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Yin and yang regulation of stress granules by Caprin-1
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Stress granules (SGs) are membraneless organelles regulating many vital biochemical processes. G3BP1 plays a critical role in regulating SG dynamics through its interaction with Caprin-1 and USP10.
Dan Song +9 more
semanticscholar +1 more source
Stress Granules and Virus Replication [PDF]
Future Virology, 2011 Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. This results in inhibition of translation and is intended to block virus replication.
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Shigella flexnerimodulates stress granule composition and inhibits stress granule aggregation [PDF]
Cellular Microbiology, 2016 Invasion and multiplication of the facultative, cytosolic, enteropathogen Shigella flexneri within the colonic epithelial lining leads to an acute inflammatory response, fever and diarrhea. During the inflammatory process, infected cells are subjected to numerous stresses including heat, oxidative stress and genotoxic stress.
Vonaesch Pascale +4 more
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Frontiers in Molecular Biosciences, 2022 Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that undergoes liquid-liquid phase separation by association with specific RNAs ...
Danella L. West +7 more
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Stress induced TDP-43 mobility loss independent of stress granules
bioRxiv, 2022 TAR DNA binding protein 43 (TDP-43) is closely related to the pathogenesis of amyotrophic lateral sclerosis (ALS) and translocates to stress granules (SGs). The role of SGs as aggregation-promoting “bioreactors” for TDP-43, however, is still under debate.
Lisa Streit +7 more
semanticscholar +1 more source
Stress granule transcription [PDF]
Science, 2018 Molecular Biology When translation initiation is stalled under stress, nontranslating messenger ribonucleoproteins form insoluble assemblies called stress granules (SGs) in the cytosol. Namkoong et al. sequenced all transcripts from purified SGs. They found that although translation of most transcripts is inhibited, only a subset of transcripts form ...
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Stress‐induced mRNP granules: Form and function of processing bodies and stress granules [PDF]
WIREs RNA, 2019 In response to stress, cells must quickly reprogram gene expression to adapt and survive. This is achieved in part by altering levels of mRNAs and their translation into proteins. Recently, the formation of two stress‐induced messenger ribonucleoprotein (mRNP) assemblies named stress granules and processing bodies has been postulated to directly impact
Anna R. Guzikowski +2 more
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