Results 71 to 80 of about 4,058,220 (323)

Ribonucleoprotein Granules: Between Stress and Transposable Elements

Biomolecules, 2023
Transposable elements (TEs) are DNA sequences that can transpose and replicate within the genome, leading to genetic changes that affect various aspects of host biology.
Sungjin Moon, Sim Namkoong
doaj   +1 more source

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

bioRxiv
Cytosolic aggregation of the nuclear protein TDP-43 is associated with many neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we demonstrate that TDP-43 aggregation requires a double event.
Xiao Yan, David Kuster, Priyesh Mohanty, J. Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M. Franzmann, Aleksandra Sergeeva, Patricia M. Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L. Danielson, Alf Honigmann, Yuna M. Ayala, N. Fawzi, J. Mittal, S. Alberti, Anthony A. Hyman   +18 more
semanticscholar   +1 more source

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

Journal of Cell Biology, 2021
Freibaum, Messing, et al. present a system that permits high-fidelity reconstitution of stress granules and the granular component of nucleoli in mammalian cellular lysate.
Brian D. Freibaum, James Messing, Peiguo Yang, Hong-Joo Kim, J. Taylor   +4 more
semanticscholar   +1 more source

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

eLife, 2015
RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein aggregates or through phase separation into a liquid RNA/protein phase. Which model describes RNP granules in living cells is still unclear.
Sonja Kroschwald, Shovamayee Maharana, Daniel Mateju, Liliana Malinovska, Elisabeth Nüske, Ina Poser, Doris Richter, Simon Alberti   +7 more
doaj   +1 more source

Limited effects of m6A modification on mRNA partitioning into stress granules

Nature Communications, 2021
The presence of the m6A modification in mammalian mRNAs is proposed to promote mRNA recruitment to stress granules through the interaction with YTHDF proteins.
A. Khong, T. Matheny, T. Huynh, Vincent Babl, R. Parker   +4 more
semanticscholar   +1 more source

Actin and microtubules position stress granules

PRX Life, 2023
AbstractMembraneless organelles, composed of protein and nucleic acids, alter the biochemical and physical landscape of the cell. While specific membraneless organelles are found in stereotypical locations, little is known about the physical mechanisms that guide their positioning.
Thomas J. Böddeker, Anja Rusch, Keno Leeners, Michael P. Murrell, Eric R. Dufresne   +4 more
openaire   +1 more source

Pathophysiology of stress granules: An emerging link to diseases (Review)

International Journal of Molecular Medicine, 2022
Under unfavorable environmental conditions, eukaryotic cells may form stress granules (SGs) in the cytosol to protect against injury and promote cell survival.
Jihui Wang, Yixia Gan, Jian-ping Cao, Xuefen Dong, W. Ouyang   +4 more
semanticscholar   +1 more source

Who Regulates Whom? An Overview of RNA Granules and Viral Infections

Viruses, 2016
After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules.
Natalia Poblete-Durán, Yara Prades-Pérez, Jorge Vera-Otarola, Ricardo Soto-Rifo, Fernando Valiente-Echeverría   +4 more
doaj   +1 more source

TRIM25 predominately associates with anti-viral stress granules

Nature Communications
Stress granules (SGs) are induced by various environmental stressors, resulting in their compositional and functional heterogeneity. SGs play a crucial role in the antiviral process, owing to their potent translational repressive effects and ability to ...
Zehua Shang, Sitao Zhang, Jinrui Wang, Lili Zhou, Xinyue Zhang, D. Billadeau, Peiguo Yang, Lingqiang Zhang, Fangfang Zhou, Peng Bai, Da Jia   +10 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source