Results 71 to 80 of about 70,206 (162)

Granular Insights on Innate and Intrinsic Immunity to Flaviviruses

Microorganisms
Interaction between pathogenic human RNA viruses and host stress granules is an active area of research. Understanding how viruses manipulate, evade, and/or parasitize stress granules and related assemblies may lead to novel approaches for therapeutic ...
Janine Hvizdos, Alex C. Hofler, Shelton S. Bradrick   +2 more
doaj   +1 more source

Stress granules [PDF]

Current Biology, 2009
Anderson, Paul, Kedersha, Nancy
openaire   +2 more sources

Ataxin-2-like is a regulator of stress granules and processing bodies.

PLoS ONE, 2012
Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis.
Christian Kaehler, Jörg Isensee, Ute Nonhoff, Markus Terrey, Tim Hucho, Hans Lehrach, Sylvia Krobitsch   +6 more
doaj   +1 more source

RNA Granules and Stress Granules in Virus Systems

Journal of Bacteriology and Virology, 2012
Viruses initiate a number of cellular stress responses and modulate gene regulation and compartmentalization of RNA upon infection to be successful parasites. Virus infections may induce or impair stress granule (SG) formation to maximize replication efficiency.
openaire   +1 more source

The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2016
In response to stressful conditions, eukaryotic cells launch an arsenal of regulatory programs to protect the proteome. One major protective response involves the arrest of protein translation and the formation of stress granules, cytoplasmic ...
Gabriela Huelgas-Morales, Carlos Giovanni Silva-García, Laura S. Salinas, David Greenstein, Rosa E. Navarro   +4 more
doaj   +1 more source

N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.

PLoS ONE, 2013
Iron is critical for cellular proliferation and its depletion leads to a suppression of both DNA synthesis and global translation. These observations suggest that iron depletion may trigger a cellular "stress response".
Darius J R Lane, Federica Saletta, Yohan Suryo Rahmanto, Zaklina Kovacevic, Des R Richardson, Des R Richardson   +5 more
doaj   +1 more source

Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1

mBio, 2015
Stress granules (SGs) are dynamic cytoplasmic repositories containing translationally silenced mRNAs that assemble upon cellular stress. We recently reported that the SG nucleating protein G3BP1 promotes antiviral activity and is essential in double ...
Lucas C. Reineke, Nancy Kedersha, Martijn A. Langereis, Frank J. M. van Kuppeveld, Richard E. Lloyd   +4 more
doaj   +1 more source

Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress

Cell Reports, 2014
The localization of mRNA to defined cytoplasmic sites in eukaryotic cells not only allows localized protein production but also determines the fate of mRNAs.
Jennifer Lui, Lydia M. Castelli, Mariavittoria Pizzinga, Clare E. Simpson, Nathaniel P. Hoyle, Kathryn L. Bailey, Susan G. Campbell, Mark P. Ashe   +7 more
doaj   +1 more source

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

Nature Communications, 2018
Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72.
Maneka Chitiprolu, Chantal Jagow, Veronique Tremblay, Emma Bondy-Chorney, Geneviève Paris, Alexandre Savard, Gareth Palidwor, Francesca A. Barry, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Janice Robertson, Mathieu Lavallée-Adam, John Woulfe, Jean-François Couture, Jocelyn Côté, Derrick Gibbings   +16 more
doaj   +1 more source

FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

eLife
Ribonucleoprotein (RNP) granules are membraneless electron-dense structures rich in RNAs and proteins, and involved in various cellular processes. Two RNP granules in male germ cells, intermitochondrial cement and the chromatoid body (CB), are associated
Yuki Kaneda, Haruhiko Miyata, Zoulan Xu, Keisuke Shimada, Maki Kamoshita, Tatsuya Nakagawa, Chihiro Emori, Masahito Ikawa   +7 more
doaj   +1 more source