Results 71 to 80 of about 90,512 (310)
Stress granules as crucibles of ALS pathogenesis [PDF]
Journal of Cell Biology, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal human neurodegenerative disease affecting primarily motor neurons. Two RNA-binding proteins, TDP-43 and FUS, aggregate in the degenerating motor neurons of ALS patients, and mutations in the genes encoding these proteins cause some forms of ALS.
James Shorter +4 more
openaire +4 more sources
Photoelastic Stress Response of Complex 3D-Printed Particle Shapes [PDF]
arXiv, 2022 While stress visualization within 3-dimensional particles would greatly advance our understanding of the behaviors of complex particles, traditional photoelastic methods suffer from a lack of available technology for producing suitable complex particles.
arxiv
Shear jamming and fragility in dense suspensions [PDF]
Granul. Matter, 21(3):82, 2019, 2019 The phenomenon of shear-induced jamming is a factor in the complex rheological behavior of dense suspensions. Such shear-jammed states are fragile, i.e., they are not stable against applied stresses that are incompatible with the stress imposed to create them.
arxiv +1 more source
Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria
FEBS Open Bio, EarlyView.The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao +4 more
wiley +1 more source
Stress granules dynamics: benefits in cancer
BMB Reports, 2022 Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and ...
Jeong In Lee, Sim Namkoong
openaire +2 more sources
Small-scale dynamo simulations: Magnetic field amplification in exploding granules and the role of deep and shallow recirculation [PDF]
, 2018 We analyze recent high resolution photospheric small-scale dynamo simulations that were computed with the MURaM radiative MHD code. We focus the analysis on newly forming downflow lanes in exploding granules since they show how weakly magnetized regions in the photosphere (center of granules) evolve into strongly magnetized regions (downflow lanes). We
arxiv +1 more source
Dynamics of small-scale convective motions [PDF]
A&A 598, A126 (2017), 2016 Previous studies have discovered a population of small granules with diameters less than 800 km showing differing physical properties. High resolution simulations and observations of the solar granulation, in combination with automated segmentation and tracking algorithms, allow us to study the evolution of the structural and physical properties of ...
arxiv +1 more source
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
Bio‐inspired functional coacervates
Aggregate, Volume 3, Issue 6, December 2022., 2022 Bio‐inspired functional coacervates have diverse functions. Natural and synthetic coacervates are a new class of materials that have great potential for various biomedical applications, including medical adhesives, drug delivery, and tissue engineering.
Shujun Chen, Qi Guo, Jing Yu
wiley +1 more source
Biochemistry and Biophysics Reports, 2021 Pesticides entering our body, either directly or indirectly, are known to increase the risk of developing neurodegenerative disorders. The pesticide-induced animal models of Parkinson's disease and Alzheimer's disease recapitulates many of the ...
Pratibha Bhadauriya +2 more
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