Results 81 to 90 of about 90,512 (310)
PLoS Pathogens, 2020 Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress granules to limit the use of ...
Michèle Brocard +11 more
doaj +1 more source
Stress fluctuations and shear thickening in dense granular suspensions [PDF]
, 2019 We experimentally investigate the rheology and stress fluctuations of granules densely suspended in silicone oil. We find that both thickening strength and stress fluctuations significantly weaken with oil viscosity $\eta_0$. Comparison of our rheological results to the Wyart-Cates model for describing different dynamic jamming states suggests a ...
arxiv +1 more source
Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron +3 more
wiley +1 more source
Stress granules, P-bodies and cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2015 Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic ...
Pavel Ivanov +4 more
openaire +3 more sources
Toward Design Principles for Biomolecular Condensates for Metabolic Pathways
Advanced Biology, EarlyView.Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André +3 more
wiley +1 more source
PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage
Cells, 2022 DNA damage causes PARP1 activation in the nucleus to set up the machinery responsible for the DNA damage response. Here, we report that, in contrast to cytoplasmic PARPs, the synthesis of poly(ADP-ribose) by PARP1 opposes the formation of cytoplasmic ...
Anastasia S. Singatulina +5 more
doaj +1 more source
Well-Ordered "Ripple-Shaped" Microstructures of Mn Thin Films on GaAs Substrates [PDF]
Advanced Science, Engineering and Medicine, Volume 11, Number 11,
November 2019, pp. 1142-1147(6), 2019 This study was aimed to investigate the thickness dependent morphological changes of Mn films deposited on GaAs substrates by thermal evaporation technique. Ni films were deposited under same conditions to perform comparative study of the morphological changes with respect to the Mn films.
arxiv +1 more source
The Quest to Understand Supergranulation and Large-Scale Convection in the Sun [PDF]
, 2013 Surface granulation of the Sun is primarily a consequence of thermal transport in the outer 1 % of the radius. Its typical scale of about 1 - 2 Mm is set by the balance between convection, free-streaming radiation, and the strong density stratification in the surface layers.
arxiv +1 more source
Nutritional stress targets LeishIF4E-3 to storage granules that contain RNA and ribosome components in Leishmania. [PDF]
PLoS Neglected Tropical Diseases, 2019 Leishmania parasites lack pathways for de novo purine biosynthesis. The depletion of purines induces differentiation into virulent metacyclic forms. In vitro, the parasites can survive prolonged periods of purine withdrawal changing their morphology to ...
Rohit Shrivastava +2 more
doaj +1 more source
Advanced Engineering Materials, EarlyView.The study presents an efficient simulation approach for the polymer laser powder bed fusion process polymers process, validated with polyamide 12, polyamide 6, and polyetherketoneketone. It shows that inter layer time affects part density, with 90s yielding dense parts.
Claas Bierwisch +4 more
wiley +1 more source