Results 1 to 10 of about 141,474 (306)
On the role of the striatum in response inhibition. [PDF]
PLoS ONE, 2010 BACKGROUND: Stopping a manual response requires suppression of the primary motor cortex (M1) and has been linked to activation of the striatum. Here, we test three hypotheses regarding the role of the striatum in stopping: striatum activation during ...
Bram B Zandbelt, Matthijs Vink
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The microcircuits of striatum in silico [PDF]
Proceedings of the National Academy of Sciences, 2020 The basal ganglia play an important role in decision making and selection of action primarily based on input from cortex, thalamus, and the dopamine system. Their main input structure, striatum, is central to this process. It consists of two types of projection neurons, together representing 95% of the neurons, and 5% of interneurons, among which are ...
Shreyas M. Suryanarayana +13 more
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Ramping activity in the striatum
Frontiers in Computational Neuroscience, 2022 Control of the timing of behavior is thought to require the basal ganglia (BG) and BG pathologies impair performance in timing tasks. Temporal interval discrimination depends on the ramping activity of medium spiny neurons (MSN) in the main BG input structure, the striatum, but the underlying mechanisms driving this activity are unclear.
Ponzi, Adam, Wickens, Jeff
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Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice [PDF]
International Neurourology Journal, 2022 Purpose In Alzheimer disease (AD), brain regions such as the cortex and the hippocampus show abundant amyloid load which correlates with cognitive function decline.
Sangjoon Lee +4 more
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Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Intracerebral hemorrhage (ICH) occurs mostly in the striatum. In ICH, blood prolactin level increases 3-fold. The effects of intracerebroventricular injection (ICV) of prolactin on motor disorders will be investigated. Materials and Methods:
Shiba Yousefvand +6 more
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A Spatiomolecular Map of the Striatum [PDF]
Cell Reports, 2019 SUMMARYThe striatum is organized into two major outputs formed by striatal projection neuron (SPN) subtypes with distinct molecular identities. In addition, the histochemical division into patch and matrix compartments represents an additional spatial organization, proposed to mirror a functional specialization in a motor-motivation dimension.
Märtin, Antje +5 more
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Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]
, 2020 Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S. +8 more
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The Journal of Neuroscience, 2020 In the mid-19th century, a misconception was born, which understandably persists in the minds of many neuroscientists today. The eminent scientist Albert von Kölliker named a tubular-shaped piece of tissue found in the brains of all mammals studied to date, the tuberculum olfactorium - or what is commonly known as the olfactory tubercle (OT).
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Laterality hotspots in the striatum [PDF]
Cerebral Cortex, 2021 Abstract Striatal loci are connected to both the ipsilateral and contralateral frontal cortex. Normative quantitation of the dissimilarity between striatal loci’s hemispheric connection profiles and its spatial variance across the striatum, and assessment of how interindividual differences relate to function, stands to further the ...
Cole Korponay +2 more
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Altered Cortical-Striatal Network in Patients With Hemifacial Spasm
Frontiers in Human Neuroscience, 2021 Objective: Hemifacial spasm (HFS) is a kind of motor disorder, and the striatum plays a significant role in motor function. The purpose of this study was to explore the alterations of the cortical-striatal network in HFS using resting-state functional ...
Wenwen Gao +14 more
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