Results 21 to 30 of about 278,206 (253)
Frontiers in Systems Neuroscience, 2022 A pipeline is proposed here to describe different features to study brain microcircuits on a histological scale using multi-scale analyses, including the uniform manifold approximation and projection (UMAP) dimensional reduction technique and modularity ...
Miguel Serrano-Reyes +8 more
doaj +1 more source
Анналы клинической и экспериментальной неврологии, 2017 Introduction.Huntingtons disease (HD) is a severe neurodegenerativedisorder characterized by choreic hyperkinesis, cognitivedecline, behavioral disorders, and progressive neuronal death,mostly in the striatum.
Alla V. Stavrovskaya +4 more
doaj +1 more source
Adult Neurogenesis and Stroke: A Tale of Two Neurogenic Niches
Frontiers in Neuroscience, 2021 In the aftermath of an acute stroke, numerous signaling cascades that reshape the brain both in the perilesional zone as well as in more distal regions are activated.
Mihai Ceanga +4 more
doaj +1 more source
Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons [PDF]
, 2014 We thank Dr. Ya-Qin Feng from Shanxi Medical University, Dr. Tian-Yun Gao from Nanjing University and Dr. Yan-Hong Xue from Institute of Biophysics (CAS) for technical assistance in this study. We are very thankful to Drs. Richard T. Swank and Xiao-Jiang
Gao, Xiang +13 more
core +3 more sources
Experience of experimental simulation of Huntington’s disease
Анналы клинической и экспериментальной неврологии, 2017 Huntingtons disease (HD) is an autosomal dominant neurodegenerativedisease characterized by choreic hyperkinesia, cognitivedecline, behavioral disorders, and progressive neuronaldeath affecting primarily the striatum.
A. V. Stavrovskaya +5 more
doaj +1 more source
Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors
Frontiers in Neurology, 2022 Understanding the kinetics and durability of AAV-mediated transgene expression in the brain is essential for conducting basic neuroscience studies as well as for developing gene therapy approaches for CNS diseases.
Bradley S. Hollidge +9 more
doaj +1 more source
Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
, 2018 We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe +12 more
core +2 more sources
Ventral Caudate and Anterior Insula Recruitment During Value Estimation of Passionate Rewarding Cues
Frontiers in Neuroscience, 2020 “Wanting”, a component of reward processing, is a motivational property that guides decision making in goal-oriented behavior. This includes behavior aiming at supporting relational bonds, even at the group level.
Isabel Catarina Duarte +6 more
doaj +1 more source
Frontiers in Neuroscience, 2020 Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade.
Helle G. Andersen +19 more
doaj +1 more source
Neural signatures of cognitive flexibility and reward sensitivity following nicotinic receptor stimulation in dependent smokers : a randomized trial [PDF]
, 2017 IMPORTANCE Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid ...
Aronson, Sarah E. +5 more
core +2 more sources