Understanding the Stringent Response: Experimental Context Matters [PDF]
mBio, 2023 As rapidly growing bacteria begin to exhaust essential nutrients, they enter a state of reduced growth, ultimately leading to stasis or quiescence. Investigation of the response to nutrient limitation has focused largely on the consequences of amino acid
Jonathan Dworkin
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Data on the transcriptional response to MESH1 knockdown and mammalian stringent response [PDF]
Data in Brief, 2023 MESH1 is the metazoan homolog of bacterial SpoT, the main phosphatase that dephosphorylates and degrades (p)ppGpp, the alarmone involved in the bacterial stringent response. The functional role of MESH1 in human cells is unknown.
Tianai Sun +2 more
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Stringent Response in Mycobacteria: From Biology to Therapeutic Potential [PDF]
Pathogens, 2021 Mycobacterium tuberculosis is a human pathogen that can thrive inside the host immune cells for several years and cause tuberculosis. This is due to the propensity of M.
Kuldeepkumar Ramnaresh Gupta +3 more
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An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis [PDF]
Frontiers in Immunology, 2022 Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation of persistent Mycobacterium tuberculosis (Mtb) to remain in a non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induction
Styliani Karanika +27 more
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Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa [PDF]
Frontiers in Microbiology, 2020 Cyanobacterial blooms are serious environmental issues in global freshwater ecosystems. Nitrogen limitation is one of the most important strategies to control cyanobacterial blooms. However, recent researches showed that N limitation does not effectively
Hui Jin +5 more
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Insight on the roles of stringent response, stringent-like response, and general stress response in hyperosmotic shock tolerance in Escherichia coli [PDF]
mBioBacteria frequently encounter osmotic stress in a variety of natural environments, and the primary protective systems they use to adapt to such stresses have been well-characterized.
Keilen Kelly, Rajeev Misra
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Targeting the bacterial stringent response to combat human pathogens [PDF]
Frontiers in ImmunologyIn the era of increasing bacterial antibiotic resistance, finding new ways of combating pathogens is especially important. An attractive possibility is targeting bacterial survival strategies that microorganisms employ either to evade the host immune ...
Filip Gąsior +3 more
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NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli [PDF]
eLife, 2021 Bacteria regulate their metabolism to adapt and survive adverse conditions, in particular to stressful downshifts in nutrient availability. These shifts trigger the so-called stringent response, coordinated by the signaling molecules guanosine tetra and ...
Loïc Léger +4 more
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The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions [PDF]
mBio, 2021 During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in ...
Daniel J. Bennison +5 more
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Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment [PDF]
Frontiers in Microbiology, 2021 The stringent response is well conserved across bacterial species and is a key pathway involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in Mycobacteria.
Carina Danchik +2 more
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