Results 41 to 50 of about 665,456 (302)

The Prospects for Immigration Amendments [PDF]

, 1956
Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and
Cao, Wei, Feng, Boya, Gao, Ning, Guo, Qiang, Lei, Jianlin, Li, Ningning, Mandava, Chandra Sekhar, Sanyal, Suparna, Wang, Jie, Wang, Zhixin, Wu, Jiawei, Zhang, Yanqing, Zhang, Yixiao   +12 more
core   +4 more sources

RelQ Mediates the Expression of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus

Frontiers in Microbiology, 2019
An induced stringent response, which is established by an increased level of (p)ppGpp, is required for the expression of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA).
Ajita Bhawini, Parul Pandey, Ashutosh Prakash Dubey, Aafreen Zehra, Gopal Nath, Mukti Nath Mishra, Mukti Nath Mishra   +6 more
doaj   +1 more source

Influence of the RelA Activity on E. coli Metabolism by Metabolite Profiling of Glucose-Limited Chemostat Cultures

Metabolites, 2012
Metabolite profiling of E. coli W3110 and the isogenic DrelA mutant cells was used to characterize the RelA-dependent stringent control of metabolism under different growth conditions.
Sónia Carneiro, Silas G. Villas-Bôas, Eugénio C. Ferreira, Isabel Rocha   +3 more
doaj   +1 more source

Codon-Dependent Transcriptional Changes in Response to Tryptophan Limitation in the Tryptophan Auxotrophic Pathogens Chlamydia trachomatis and Streptococcus pyogenes

mSystems, 2021
Chlamydia trachomatis and Streptococcus pyogenes are among the most prevalent bacterial pathogens of humans. Interestingly, both pathogens are tryptophan (Trp) auxotrophs and must acquire this essential amino acid from their environment.
Scot P. Ouellette, Nathan D. Hatch, Nicholas A. Wood, Andrea L. Herrera, Michael S. Chaussee   +4 more
doaj   +1 more source

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria [PDF]

, 2016
The stringent response is a survival mechanism used by bacteria to deal with stress. It is coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival.
Bellows, L.E., Corrigan, R., Grundling, A., Wood, A.   +3 more
core   +1 more source

Physiology and Transcriptional Analysis of (p)ppGpp-Related Regulatory Effects in Corynebacterium glutamicum

Frontiers in Microbiology, 2019
The alarmone species ppGpp and pppGpp are elementary components of bacterial physiology as they both coordinate the bacterial stress response and serve as fine-tuners of general metabolism during conditions of balanced growth.
Matthias Ruwe, Marcus Persicke, Tobias Busche, Benjamin Müller, Jörn Kalinowski   +4 more
doaj   +1 more source

Identification of a RelA/SpoT Homolog and Its Possible Role in the Accumulation of Astaxanthin in Haematococcus pluvialis

Frontiers in Plant Science, 2022
A RelA/SpoT homolog, HpRSH, was identified in Haematococcus pluvialis. HpRSH was found to catalyze Mg2+-dependent guanosine tetraphosphate (ppGpp) synthesis and Mn2+-dependent ppGpp hydrolysis, respectively.
Hui Jin, Hui Jin, Yong Min Lao, Jin Zhou, Zhong Hua Cai   +4 more
doaj   +1 more source

The stringent response in Streptomyces coelicolor A3(2) [PDF]

Molecular Microbiology, 1991
SummaryThe stringent response was elicited in the antibiotic producer Streptomyces coelicolor A3(2) either by amino acid depletion (nutritional shiftdown) or by the addition of serine hydroxamate; both led to increased levels of ppGpp and to a reduction in transcription from the four promoters of the rrnD rRNA gene set.
Strauch, E., Takano, E., Baylis, H. A., Bibb, M. J.   +3 more
openaire   +3 more sources

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

Frontiers in Microbiology, 2020
The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be ...
Hiraku Takada, Hiraku Takada, Mohammad Roghanian, Mohammad Roghanian, Victoriia Murina, Victoriia Murina, Ievgen Dzhygyr, Ievgen Dzhygyr, Rikinori Murayama, Genki Akanuma, Gemma C. Atkinson, Abel Garcia-Pino, Abel Garcia-Pino, Vasili Hauryliuk, Vasili Hauryliuk, Vasili Hauryliuk   +15 more
doaj   +1 more source

Pleiotropic effects of PipX, PipY, or RelQ overexpression on growth, cell size, photosynthesis, and polyphosphate accumulation in the cyanobacterium Synechococcus elongatus PCC7942

Frontiers in Microbiology, 2023
The cyanobacterial protein PipY belongs to the Pyridoxal-phosphate (PLP)-binding proteins (PLPBP/COG0325) family of pyridoxal-phosphate-binding proteins, which are represented in all three domains of life.
Antonio Llop, Antonio Llop, Jose I. Labella, Marina Borisova, Karl Forchhammer, Khaled A. Selim, Asunción Contreras   +6 more
doaj   +1 more source