Results 11 to 20 of about 313,405 (294)

Cadherin‐6 is a novel mediator for the migration of mesenchymal stem cells to glioblastoma cells in response to stromal cell‐derived factor‐1 [PDF]

FEBS Open Bio
Glioblastoma recruits various nontransformed cells from distant tissues. Although bone marrow‐derived mesenchymal stem cells (MSCs) have been observed migrating to glioblastoma, the underlying mechanism driving MSC migration toward glioblastoma remains ...
Aran Park, Seung‐Eun Kim, Jinyeong Yu, Donghyun Son, Kyung‐Sup Kim, Eunjin Koh, Ki‐Sook Park   +6 more
doaj   +2 more sources

Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis [PDF]

Therapeutic Advances in Chronic Disease, 2019
With age, joints become subject to chronic inflammatory processes that lead to degeneration of articular cartilage. Although multifactorial, cytokines have been shown to play a role in the pathogenesis of these chronic disease states.
Robert Bragg, William Gilbert, Ahmed M. Elmansi, Carlos M. Isales, Mark W. Hamrick, William D. Hill, Sadanand Fulzele   +6 more
doaj   +2 more sources

Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation [PDF]

Journal of International Medical Research, 2019
Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem ...
Zejia Sun, Xin Li, Xiang Zheng, Peng Cao, Baozhong Yu, Wei Wang   +5 more
doaj   +2 more sources

The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs

Journal of Orthopaedic Surgery and Research, 2020
Objective To explore the possibility and mechanism of targeted blocking SDF-1/CXCR4 signaling pathway using three antagonists TN14003, T140, and AMD3100 in vivo, and to investigate the function of three antagonists in delay degeneration process of ...
Guoliang Wang, Yanlin Li, Xuhan Meng, Xiao Yang, Yaoyu Xiang   +4 more
doaj   +1 more source

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia [PDF]

, 2006
Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth ...
Aicher, A, Dimmeler, S, Heeschen, C, Sasaki, K, Urbich, C, Zeiher, AM   +5 more
core   +1 more source

SDF-1 and PDGF enhance [alpha]v[beta]5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines [PDF]

, 2009
CD23 acts through the [alpha]v[beta]5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. [alpha]v[beta]5 is expressed on normal B-cell precursors in the bone marrow.
Acharya, M., Cushley, W., Edkins, A.L., Ozanne, B.W.   +3 more
core   +2 more sources

Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4). [PDF]

, 2012
The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade.
Fujii, Nobutaka, Oishi, Shinya
core   +1 more source

Stromal Cell-Derived Factor-1 Promotes Cell Migration, Tumor Growth of Colorectal Metastasis

Neoplasia: An International Journal for Oncology Research, 2007
In a mouse model of established extrahepatic colorectal metastasis, we analyzed whether stromal cellderived factor (SDF) 1 stimulates tumor cell migration in vitro, angiogenesis, tumor growth in vivo.
Otto Kollmar, Kathrin Rupertus, Claudia Scheuer, Bastian Junker, Bettina Tilton, Martin K. Schilling, Michael D. Menger   +6 more
doaj   +1 more source

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]

, 2017
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl, Chasseing, Norma Alejandra, Choi, Hosoon, Davies, Kevin Mauro, de Luján Calcagno, María, Feldman, Leonardo, García Rivello, Hernán, Giorello, María Belén, Howard, Scott C., Labovsky, Vivian, Martinez, Leandro Marcelo, Matas, Ayelen, Wernicke, Alejandra   +12 more
core   +2 more sources

Stromal Cell-Derived Factor-1 Retention and Cardioprotection for Ischemic Myocardium [PDF]

Circulation: Heart Failure, 2011
Background— Stromal cell-derived factor-1 (SDF-1) is a chemoattractant of stem/progenitor cells, and several studies have shown that SDF-1 may improve ventricular function after infarction. SDF-1 is cleaved by proteases including matrix metalloproteinase-2 (MMP-2) and CD26/dipeptidylpeptidase-4 (DPP-4), which are activated in ...
Sachiko, Kanki, Vincent F M, Segers, Weitao, Wu, Rahul, Kakkar, Joseph, Gannon, Stanislas U, Sys, Anthony, Sandrasagra, Richard T, Lee   +7 more
openaire   +2 more sources