Results 51 to 60 of about 13,761 (295)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Molecular characterization of STRs.

, 2016
Molecular characterization of STRs.
Yi Liu (36759), Kaihui Zhang (2162758), Yali Yang (2162755), Rui Dong (432995), Haiyan Zhang (176919), Zhongtao Gai (702953), Shu Liu (160219), Bing Feng (124644)   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Genetic investigation and phylogenetic analysis of three Chinese ethnic groups using 16 X chromosome STR loci

Annals of Human Biology, 2020
Background: The value of using X-chromosomal short tandem repeats (X-STRs) as genetic markers in human genetics has been widely recognised. However, the 16 X-STRs in the Goldeneye® DNA ID System 17X kit have not been thoroughly applied.
Ruiyang Tao, Jingyi Zhang, Ruocheng Xia, Zihao Yang, Shouyu Wang, Xiaochun Zhang, Qi Yang, Suhua Zhang, Chengtao Li   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

STRs data and pedigree analysis.

, 2022
(A) STRs data analysed on GeneMarker Software, with HBB5178, D11S1760, HBB5576, HBB5205 in blue, and D11S1243, HBB5138 in green; (B) Pedigree analysis of Couple 15, with mutated allele received from the mother (in red) and the father in (blue).
The-Hung Bui (6760736), Phuong Le Thi (321683), Thinh Huy Tran (14232206), Nha Nguyen Thi (14232212), Thanh Van Ta (6760739), Vu Viet Ha Vuong (14232203), Phuoc-Dung Nguyen (14232209), Manh-Ha Nguyen (14232218), Dang Thi Minh Nguyet (14232215), Van-Khanh Tran (14232221)   +9 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Mutation Rates and Discriminating Power for 13 Rapidly-Mutating Y-STRs between Related and Unrelated Individuals.

PLoS ONE, 2016
Rapidly Mutating Y-STRs (RM Y-STRs) were recently introduced in forensics in order to increase the differentiation of Y-chromosomal profiles even in case of close relatives.
Alessio Boattini, Stefania Sarno, Carla Bini, Valeria Pesci, Chiara Barbieri, Sara De Fanti, Andrea Quagliariello, Luca Pagani, Qasim Ayub, Gianmarco Ferri, Davide Pettener, Donata Luiselli, Susi Pelotti   +12 more
doaj   +1 more source

Osoriellus -, s. str.

, 2014
Osoriellus - s. str. -group The species group is defined by the characters described by FAGEL (1959) for the genus Osoriellus: no digits at the outer edge of the protibia, narrow lateral margin of the pronotum, sides of the pronotum evenly curved from anterior to posterior angles and asymmetric aedeagus with lateral opening.
openaire   +2 more sources