Results 81 to 90 of about 76,107 (347)

Osoriellus -, s. str.

, 2014
Osoriellus - s. str. -group The species group is defined by the characters described by FAGEL (1959) for the genus Osoriellus: no digits at the outer edge of the protibia, narrow lateral margin of the pronotum, sides of the pronotum evenly curved from anterior to posterior angles and asymmetric aedeagus with lateral opening.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Evaluation of rapidly mutating Y-STRs in Pakistani population

, 2019
Y-chromosomal Short Tandem Repeats have been widely used in forensic investigations, identification of males for criminal justice purpose and population genetics.
Almheiri, R., Adam, A., Khan, M.R., Absar, M., Almulla, H., Rauf, S., Tracy, M., Alghafri, R., Farhatullah, M., Khan, MR R.   +9 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effectiveness and tolerance of single tablet versus once daily multiple tablet regimens as first-line antiretroviral therapy - Results from a large french multicenter cohort study.

PLoS ONE, 2017
ObjectivesPill burden during antiretroviral treatment (ART) is associated with worse adherence and impaired virological suppression. We compared the effectiveness, tolerance, and persistence on treatment of single tablet regimens (STRs) with non-STR once-
Laurent Cotte, Tristan Ferry, Pascal Pugliese, Marc-Antoine Valantin, Clotilde Allavena, André Cabié, Isabelle Poizot-Martin, David Rey, Claudine Duvivier, Antoine Cheret, Pierre Dellamonica, Pierre Pradat, Jean-Jacques Parienti, Dat’AIDS study group   +13 more
doaj   +1 more source

IMa2 input file (mtDNA and STRs)

, 2017
Sample input file for IMa2 analysis of two geographical populations from P. pityusensis with 16 loci (2430 bp mtDNA sequence and 15 STRs)
Virginia Rodríguez (84777), Richard Brown (130157), Valentin Pérez-Mellado (290148), Antonia Picornell (7058816), Jose Castro (6199868), M. Misericordia Ramon (7058819), Barbara Terrasa (7058813)   +6 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Development and Psychometric Analysis of the Student-Teacher Relationship Scale - Short Form

Frontiers in Psychology, 2015
The purpose of this study is the construction and validation of an Italian Short Form version of the Student-Teacher Relationship Scale (Pianta 2001; STRS-SF) in the Italian educational setting for 1256 Students and 210 teachers.
Michele eSettanni, Claudio eLongobardi, Erica eSclavo, Michela eFraire, Laura Elvira Prino   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Dinucleotide (CA)n tandem repeats on the human X-chromosome and the history of the Mediterranean populations

Annals of Human Biology, 2018
Background: Tandem repeats (STRs) are genomic markers of particular interest in forensic and population genetics. Most of the population data currently available correspond to the variation of STRs of forensic panels, which barely include dinucleotide ...
Josep Santamaría, Miguel M. Álvarez-Álvarez, M. Esther Esteban, Elies Ramon-Gurrea, Pedro Moral   +4 more
doaj   +1 more source