Results 41 to 50 of about 147,460 (329)

Bleeding Time and False Aneurysm Incidence on Cattle Slaughtering Using Non-Penetrative Pre-Slaughter Stunning in Indonesia

open access: yesTropical Animal Science Journal, 2022
The use of non-penetrating pre-slaughter stunning (NPPSS) in ruminants remains a contentious issue in Indonesia since it is thought to interfere with the bleeding.
Supratikno   +3 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Effect of neck cut position on time to collapse in halal slaughtered cattle without stunning [PDF]

open access: yes, 2015
This study examined the effect of neck cut position on the time to physical collapse in upright restrained halal slaughtered cattle (n = 644). Time to collapse was used as an indirect indicator of the early stages of onset of unconsciousness. Cattle were
Dadios, N, Gibson, T J, Gregory, N G
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

open access: yesFEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Stretch‐Induced Increase in Cardiac Contractility Is Independent of Myocyte Ca\u3csup\u3e2+\u3c/sup\u3e While Block of Stretch Channels by Streptomycin Improves Contractility After Ischemic Stunning [PDF]

open access: yes, 2015
Stretching the cardiac left ventricle (LV) enhances contractility but its effect on myoplasmic [Ca2+] is controversial. We measured LV pressure (LVP) and [Ca2+] as a function of intra-LV stretch in guinea pig intact hearts before and after 15 min global ...
Aldakkak, Mohammed   +4 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Haematological changes to assess stress arising from different methods of slaughtering in pigs

open access: yesIndian Journal of Animal Sciences
This study aimed to investigate the blood profile and neutrophil and lymphocyte ratio (NLR) in pigs subjected to stunning and non-stunning. Forty pigs, aged between 6-8 months and weighing 80-100 kg, were used to assess haematological changes associated
I WAYAN SUARDANA   +2 more
doaj   +1 more source

Myocardial stunning: A therapeutic conundrum [PDF]

open access: yesThe Journal of Thoracic and Cardiovascular Surgery, 1995
Dobutamine and pyruvate are two inotropic agents with different mechanisms of action. Although both agents alter postischemic myocardial dysfunction, their potential metabolic effects in the setting of in vivo myocardial stunning have not been addressed.
Robert D. Lasley   +4 more
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

MNS Lab Technician Wins International Microphotography Competition [PDF]

open access: yes, 2013
Combining science and art, Kathryn Markey earns honors in Olympus BioScapes Competition for stunning video of marine life on microscopic ...
Public Affairs, Roger Williams University
core   +1 more source

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