Results 51 to 60 of about 21,266 (292)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Animals, 2023 Background: According to EU legislation, animal-based indicators (ABMs) are used to evaluate the efficacy of stunning methods to ensure that animals do not regain consciousness.
Marta Comin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Stunning methods and slaughter of rabbits for human consumption
EFSA Journal, 2020 This opinion on the killing of rabbits for human consumption (‘slaughtering’) responds to two mandates: one from the European Parliament (EP) and the other from the European Commission.
EFSA Panel on Animal Health and Welfare (AHAW) +22 more
doaj +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Scientific Opinion on the use of carbon dioxide for stunning rabbits [PDF]
EFSA Journal, 2013 The Panel on Animal Health and Welfare was asked to deliver a scientific opinion on the use of carbon dioxide for stunning rabbits. Specifically, EFSA was asked to give its view on the findings of the study performed by the Polytechnic University of ...
EFSA Panel on Animal Health and Welfare (AHAW)
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Scientific Papers Animal Science and Biotechnologies, 2023 There is a growing concern of consumers that the meat producing animals are bred, reared, handled and slaughtered in ways that are sympathetic to their welfare status.
E. SZÜCS +3 more
doaj
Endothelial and myocardial stunning [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2003 AbstractJ Thorac Cardiovasc Surg 2003;125:S92 ...
openaire +2 more sources