Mechanisms that Determine the Differential Stability of Stx+ and Stx− Lysogens [PDF]
Toxins, 2016 Phages 933W, BAA2326, 434, and λ are evolutionarily-related temperate lambdoid phages that infect Escherichia coli. Although these are highly-similar phages, BAA2326 and 933W naturally encode Shiga toxin 2 (Stx+), but phage 434 and λ do not (Stx−). Previous reports suggest that the 933W Stx+ prophage forms less stable lysogens in E.
Colon, Michael +3 more
openaire +3 more sources
Comparative genomics of Shiga toxin encoding bacteriophages [PDF]
BMC Genomics, 2012 Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, life-threatening disease and Stx toxin is an integral virulence factor.
Smith Darren L +6 more
doaj +3 more sources
Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity [PDF]
Toxins, 2021 Human kidney epithelial cells are supposed to be directly involved in the pathogenesis of the hemolytic–uremic syndrome (HUS) caused by Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC). The characterization of the major and minor Stx-binding glycosphingolipids (GSLs) globotriaosylceramide (Gb3Cer) and globotetraosylceramide (Gb4Cer)
Johanna Detzner +7 more
openaire +6 more sources
STX-S vaccine elicited a robust long lasting immune response and a potent booster. [PDF]
, 2023 STX-S vaccine induced robust expression of SARS-CoV-2 Spike antibodies and IgG levels were maintained overtime. STX-S booster injection induced robust expression of SARS-CoV-2 Spike antibodies. PBS was used as a vehicle control in all studies.
Justin B. Nice (16865908) +10 more
core +1 more source
STX-S exosome vaccine elicited a robust immune response using significantly lower amounts of antigen compared to recombinant protein vaccines. [PDF]
, 2023 The STX-S vaccine induced robust expression of SARS-CoV-2 spike antibodies in mice after 1 (day 14) and 2 (day 35) IM injections as analyzed by ELISA. PBS was used as a vehicle control in all studies. STX-S vaccine exosomes were administered at the doses
Justin B. Nice (16865908) +10 more
core +1 more source
sj-pdf-1-stx-10.1177_07352751221113019 – Supplemental material for “All the Old Illusions”: On Guessing at Being in Crisis [PDF]
, 2022 Supplemental material, sj-pdf-1-stx-10.1177_07352751221113019 for “All the Old Illusions”: On Guessing at Being in Crisis by Ioana Sendroiu in Sociological ...
Ioana Sendroiu (11513905)
core +1 more source
sj-docx-1-stx-10.1177_07352751231203716 – Supplemental material for The Moral Career of the Genocide Perpetrator: Cognition, Emotions, and Dehumanization as a Consequence, Not a Cause, of Violence [PDF]
, 2023 Supplemental material, sj-docx-1-stx-10.1177_07352751231203716 for The Moral Career of the Genocide Perpetrator: Cognition, Emotions, and Dehumanization as a Consequence, Not a Cause, of Violence by Aliza Luft in Sociological ...
Aliza Luft (17291928)
core +1 more source
Characterization of STX-S cells and exosomes expressing spike. [PDF]
, 2023 (A) Diagram of STX-S construct. (B) High expression of spike was detected on cell surface (blue) by flow cytometry. Parent, non-engineered 293F cells (light green) do not express SARS-CoV-2 spike protein, as expected.
Justin B. Nice (16865908) +10 more
core +1 more source
Shiga toxin increases formation of clathrin-coated pits through Syk kinase. [PDF]
PLoS ONE, 2010 Clathrin-dependent endocytosis is a main entry mechanism for the glycolipid-binding Shiga toxin (Stx), although clathrin-independent pathways are also involved.
Audrun Utskarpen +5 more
doaj +1 more source
Anais da Academia Brasileira de Ciências, 2022 In freshwater, saxitoxins (STX) are produced by different cyanobacteria genera, including Raphidiopsis. Data regarding cytogenotoxicity effects of STX on human cells are scarse, this merit further studies of its toxicology.
JULIANY S. CONSTANTE +6 more
doaj +1 more source