Results 11 to 20 of about 17,611 (220)

Mechanisms that Determine the Differential Stability of Stx+ and Stx− Lysogens

Toxins, 2016
Phages 933W, BAA2326, 434, and λ are evolutionarily-related temperate lambdoid phages that infect Escherichia coli. Although these are highly-similar phages, BAA2326 and 933W naturally encode Shiga toxin 2 (Stx+), but phage 434 and λ do not (Stx−). Previous reports suggest that the 933W Stx+ prophage forms less stable lysogens in E.
Colon, Michael, Chakraborty, Dolonchapa, Pevzner, Yonatan, Koudelka, Gerald   +3 more
openaire   +3 more sources

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

BMC Genomics, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, life-threatening disease and Stx toxin is an integral virulence factor.
Smith Darren L, Rooks David J, Fogg Paul CM, Darby Alistair C, Thomson Nick R, McCarthy Alan J, Allison Heather E   +6 more
doaj   +2 more sources

Model predicts coastal paralytic shellfish toxicity in mussels from in situ phytoplankton concentrations. [PDF]

Limnol Oceanogr
Abstract Harmful algal blooms (HABs) of Alexandrium catenella occur annually in the Gulf of Maine, leading to accumulation of paralytic shellfish toxins (PSTs) in bivalve mollusks and closure of harvesting areas. State monitoring programs in the region rely on weekly shellfish sampling and toxin analysis, requiring extensive effort with limited ...
Gaillard S, Ralston DK, Bricelj VM, Marin R, Keafer B, McGillicuddy DJ, Anderson DM.   +6 more
europepmc   +2 more sources

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]

, 2013
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Pérez, Ma. Teresa, Imamovic, Lejla   +1 more
core   +3 more sources

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor-Binding and Non-Canonical Assembly Sites. [PDF]

Adv Sci (Weinh)
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Ke J, Li X, Wang X, Huang Z, Xue S, Liu Y, Pan J, Hu G, Wang Y, Wang C, Chen S.   +10 more
europepmc   +2 more sources

Bacteriófagos portadores del gen de la Stx 2 en aguas [PDF]

, 1998
[spa] Los bacteriófagos portadores de genes están relacionados con la patogenicidad de las bacterias a las que infectan. Los fagos representan, pues, potenciales elementos móviles entre especies bacterianas filogenéticamente cercanas.
Muniesa Pérez, Ma. Teresa
core   +7 more sources

STX-S vaccine elicited a robust long lasting immune response and a potent booster.

, 2023
STX-S vaccine induced robust expression of SARS-CoV-2 Spike antibodies and IgG levels were maintained overtime. STX-S booster injection induced robust expression of SARS-CoV-2 Spike antibodies. PBS was used as a vehicle control in all studies.
Justin B. Nice (16865908), Kristi Elliott (16865923), Minghao Sun (2368234), Mafalda Cacciottolo (16865905), Michael J. LeClaire (7908947), Meredith Young (5108894), Jenna Angeles (16865920), Ryan Twaddle (16865911), Yujia Li (436877), Ciana L. Mora (16865914), Stephanie Y. Adachi (16865917)   +10 more
core   +1 more source

Shiga toxin increases formation of clathrin-coated pits through Syk kinase. [PDF]

PLoS ONE, 2010
Clathrin-dependent endocytosis is a main entry mechanism for the glycolipid-binding Shiga toxin (Stx), although clathrin-independent pathways are also involved.
Audrun Utskarpen, Ramiro Massol, Bo van Deurs, Silje Ugland Lauvrak, Tomas Kirchhausen, Kirsten Sandvig   +5 more
doaj   +1 more source

STX-S exosome vaccine elicited a robust immune response using significantly lower amounts of antigen compared to recombinant protein vaccines.

, 2023
The STX-S vaccine induced robust expression of SARS-CoV-2 spike antibodies in mice after 1 (day 14) and 2 (day 35) IM injections as analyzed by ELISA. PBS was used as a vehicle control in all studies. STX-S vaccine exosomes were administered at the doses
Justin B. Nice (16865908), Kristi Elliott (16865923), Minghao Sun (2368234), Mafalda Cacciottolo (16865905), Michael J. LeClaire (7908947), Meredith Young (5108894), Jenna Angeles (16865920), Ryan Twaddle (16865911), Yujia Li (436877), Ciana L. Mora (16865914), Stephanie Y. Adachi (16865917)   +10 more
core   +1 more source

In vitro and in silico assessment of cytotoxicity and chromosome instability induced by saxitoxin in human derived neural cell line

Anais da Academia Brasileira de Ciências, 2022
In freshwater, saxitoxins (STX) are produced by different cyanobacteria genera, including Raphidiopsis. Data regarding cytogenotoxicity effects of STX on human cells are scarse, this merit further studies of its toxicology.
JULIANY S. CONSTANTE, JULIANA E. AL KHATEEB, ANA PAULA DE SOUZA, FELIPE U. CONTER, MAURÍCIO LEHMANN, JOÃO S. YUNES, RAFAEL R. DIHL   +6 more
doaj   +1 more source