Results 11 to 20 of about 16,203 (230)

Mechanisms that Determine the Differential Stability of Stx+ and Stx− Lysogens

Toxins, 2016
Phages 933W, BAA2326, 434, and λ are evolutionarily-related temperate lambdoid phages that infect Escherichia coli. Although these are highly-similar phages, BAA2326 and 933W naturally encode Shiga toxin 2 (Stx+), but phage 434 and λ do not (Stx−). Previous reports suggest that the 933W Stx+ prophage forms less stable lysogens in E.
Michael Colon, Dolonchapa Chakraborty, Yonatan Pevzner, Gerald Koudelka   +3 more
openaire   +3 more sources

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

BMC Genomics, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, life-threatening disease and Stx toxin is an integral virulence factor.
Smith Darren L, Rooks David J, Fogg Paul CM, Darby Alistair C, Thomson Nick R, McCarthy Alan J, Allison Heather E   +6 more
doaj   +2 more sources

Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity [PDF]

Toxins, 2021
Human kidney epithelial cells are supposed to be directly involved in the pathogenesis of the hemolytic–uremic syndrome (HUS) caused by Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC). The characterization of the major and minor Stx-binding glycosphingolipids (GSLs) globotriaosylceramide (Gb3Cer) and globotetraosylceramide (Gb4Cer)
Johanna Detzner, Elisabeth Krojnewski, Gottfried Pohlentz, Daniel Steil, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing   +7 more
openaire   +5 more sources

Integrative Modular, Network-Based, and Machine Learning Framework for Predicting Accessory Genome Functions and Virulence in Escherichia coli O157:H7. [PDF]

Microbiologyopen
An analysis of the accessory genomes from 77 Escherichia coli O157:H7 strains using network and machine learning techniques uncovers modular communities of plasmid‐related virulence associated with IncF replicons. Accessory markers that are not directly linked to toxin genes can effectively predict the virulence status with an AUC of 0.85, facilitating
Gambushe SM, Zishiri OT.
europepmc   +2 more sources

STX-S vaccine elicited a robust long lasting immune response and a potent booster.

, 2023
STX-S vaccine induced robust expression of SARS-CoV-2 Spike antibodies and IgG levels were maintained overtime. STX-S booster injection induced robust expression of SARS-CoV-2 Spike antibodies. PBS was used as a vehicle control in all studies.
Justin B. Nice (16865908), Kristi Elliott (16865923), Minghao Sun (2368234), Mafalda Cacciottolo (16865905), Michael J. LeClaire (7908947), Meredith Young (5108894), Jenna Angeles (16865920), Ryan Twaddle (16865911), Yujia Li (436877), Ciana L. Mora (16865914), Stephanie Y. Adachi (16865917)   +10 more
core   +1 more source

STX-S exosome vaccine elicited a robust immune response using significantly lower amounts of antigen compared to recombinant protein vaccines.

, 2023
The STX-S vaccine induced robust expression of SARS-CoV-2 spike antibodies in mice after 1 (day 14) and 2 (day 35) IM injections as analyzed by ELISA. PBS was used as a vehicle control in all studies. STX-S vaccine exosomes were administered at the doses
Justin B. Nice (16865908), Kristi Elliott (16865923), Minghao Sun (2368234), Mafalda Cacciottolo (16865905), Michael J. LeClaire (7908947), Meredith Young (5108894), Jenna Angeles (16865920), Ryan Twaddle (16865911), Yujia Li (436877), Ciana L. Mora (16865914), Stephanie Y. Adachi (16865917)   +10 more
core   +1 more source

sj-pdf-1-stx-10.1177_07352751221113019 – Supplemental material for “All the Old Illusions”: On Guessing at Being in Crisis

, 2022
Supplemental material, sj-pdf-1-stx-10.1177_07352751221113019 for “All the Old Illusions”: On Guessing at Being in Crisis by Ioana Sendroiu in Sociological ...
Ioana Sendroiu (11513905)
core   +1 more source

Long term exposure of saxitoxin induced cognitive deficits and YAP1 cytoplasmic retention

Ecotoxicology and Environmental Safety, 2023
While most studies assessed the acute toxicity of saxitoxin (STX), fewer studies focus on the long-term degenerative effects of STX on the central nervous system.
Shenpan Li, Xiao Chen, Qian Sun, Xiaohu Ren, Jiacheng Zhong, Li Zhou, Hongyu Zhang, Guowei Li, Yungang Liu, Jianjun Liu, Haiyan Huang   +10 more
doaj   +1 more source

sj-docx-1-stx-10.1177_07352751231203716 – Supplemental material for The Moral Career of the Genocide Perpetrator: Cognition, Emotions, and Dehumanization as a Consequence, Not a Cause, of Violence

, 2023
Supplemental material, sj-docx-1-stx-10.1177_07352751231203716 for The Moral Career of the Genocide Perpetrator: Cognition, Emotions, and Dehumanization as a Consequence, Not a Cause, of Violence by Aliza Luft in Sociological ...
Aliza Luft (17291928)
core   +1 more source

Genetic and antimicrobial resistance profiles of non-O157 Shiga toxin-producing Escherichia coli from different sources in Egypt

BMC Microbiology, 2021
Background The Shiga toxin-producing Escherichia coli (STEC) represented a great risk to public health. In this study, 60 STEC strains recovered from broiler and duck fecal samples, cow’s milk, cattle beef, human urine, and ear discharge were screened ...
Mohamed Sabry Abd Elraheam Elsayed, Samah Mahmoud Eldsouky, Tamer Roshdy, Abeer Mohamed Ahmed Bayoume, Ghada M. Nasr, Ali S. A. Salama, Behiry A. Akl, Al Shaimaa Hasan, Amany Kasem Shahat, Rana Atef Khashaba, Walid Abdellatif Abdelhalim, Hend E. Nasr, Lina Abdelhady Mohammed, Ahmed Salah   +13 more
doaj   +1 more source